Trinexovas 20 Tablet

TRINEXOVAS 20 TABLET is a combination medicine manufactured by Macleods Pharmaceuticals Pvt Ltd, primarily used for the management of high blood pressure.

• Name: TRINEXOVAS 20 TABLET

• Composition: Each tablet contains Olmesartan Medoxomil 20 mg, Cilnidipine 10 mg, and Chlorthalidone 12.5 mg.

• Uses: This medication is prescribed for the treatment of essential hypertension (high blood pressure) in adults, particularly when a single medication is insufficient to control blood pressure. It helps to relax blood vessels, reduce excess fluid, and lower blood pressure, thereby reducing the risk of associated complications like heart attack, stroke, and kidney problems.

• Dosage and Administration: TRINEXOVAS 20 TABLET is typically taken orally, once daily, with or without food, as advised by a physician. Tablets should be swallowed whole and not crushed or chewed. Due to the diuretic component, it is advisable to avoid taking it close to bedtime. The dose and duration depend on the patient's condition and response to treatment.

• Side Effects:

  • Common: Dizziness, headache, nausea, fatigue, ankle swelling (peripheral oedema), stomach pain, diarrhoea, indigestion, constipation, increased uric acid, taste changes, and flushing.
  • Serious: Severe dizziness or fainting, muscle cramps or irregular heartbeat (indicating low potassium), yellowing of skin/eyes (signs of liver damage), sudden weight gain or swelling (kidney issues), and allergic reactions (rash, itching, breathing difficulty).

• Precautions: TRINEXOVAS 20 TABLET is not recommended during pregnancy or breastfeeding due to potential risks to the baby. Caution is advised in elderly patients, and those with severe kidney or liver disease (including anuria), low blood pressure, heart conditions, diabetes, or gout. Alcohol consumption and grapefruit juice should be avoided as they may increase side effects. Inform your doctor about all other medications, supplements, and pre-existing medical conditions to avoid potential drug interactions.

• Storage: Store below 25°C or 30°C, protected from moisture and light. Keep out of reach of children.

TRINEXOVAS 20 TABLET is a medication primarily used to manage high blood pressure (hypertension). It is manufactured by Macleods Pharmaceuticals Pvt Ltd and contains a combination of three active ingredients: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.

Here are some frequently asked questions about TRINEXOVAS 20 TABLET:

What is TRINEXOVAS 20 TABLET used for?

TRINEXOVAS 20 TABLET is primarily used to treat essential hypertension, also known as high blood pressure, in adults. It is often prescribed when a single medication is not sufficient to control blood pressure. By effectively lowering high blood pressure, it helps to reduce the risk of serious complications such as heart attack, stroke, kidney failure, and vision problems.

How does TRINEXOVAS 20 TABLET work?

TRINEXOVAS 20 TABLET is a combination of three medicines that work together to lower blood pressure.

• Olmesartan medoxomil is an angiotensin receptor blocker (ARB) that works by blocking the hormone angiotensin, which helps to relax and widen blood vessels, allowing blood to flow more smoothly.
• Cilnidipine is a calcium channel blocker (CCB) that relaxes the smooth muscles in the walls of your blood vessels, causing them to dilate and reducing the heart's workload, making it more efficient at pumping blood.
• Chlorthalidone is a diuretic (water pill) that helps the body remove extra water and certain electrolytes through urine. This reduces the total blood volume and cardiac output, leading to lower blood pressure.

What is the usual dosage for TRINEXOVAS 20 TABLET?

The recommended dosage for TRINEXOVAS 20 TABLET is usually once a day, or as advised by your doctor. The tablet should be swallowed whole with a glass of water and should not be crushed, chewed, or broken. It can be taken with food to avoid stomach upset. To maintain consistent levels in your body, it is advisable to take it at the same time each day. Avoid taking it within four hours of bedtime due to its diuretic effect, which increases urination. Your doctor will determine the appropriate dose and duration based on your medical condition and response to the treatment.

What are the possible side effects of TRINEXOVAS 20 TABLET?

Common side effects may include dizziness, headache, nausea, peripheral oedema (swelling of legs/hands/ankles), fatigue, weakness, muscle cramps, diarrhea, constipation, upset stomach, taste change, increased uric acid, glucose intolerance, palpitations, and sleepiness. Most of these side effects are temporary and generally resolve over time.

More serious, though less common, side effects require immediate medical attention. These include severe dizziness or fainting, muscle cramps or irregular heartbeat (which could be due to low potassium), yellowing of the eyes or skin (signs of liver problems), sudden weight gain or swelling (signs of kidney issues), or skin rash, itching, or trouble breathing (possible allergic reaction).

Is TRINEXOVAS 20 TABLET safe during pregnancy or breastfeeding?

During pregnancy: TRINEXOVAS 20 TABLET is not recommended for use during pregnancy, especially during the second and third trimesters, as there is a definite risk of harm to the developing baby. If you are pregnant or planning to conceive, you must inform your doctor before starting this medicine.

During breastfeeding: TRINEXOVAS 20 TABLET is generally not recommended while breastfeeding because its components may pass into breast milk, and the effect on the baby is not known. It is important to consult your doctor to discuss the potential risks and benefits.

Can TRINEXOVAS 20 TABLET be taken with other medications?

TRINEXOVAS 20 TABLET can interact with several other medications, which may alter its effectiveness or increase the risk of side effects. It is crucial to inform your doctor about all prescription and non-prescription medicines, herbal preparations, and supplements you are currently taking.

Some notable interactions include:

• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen may reduce its blood pressure-lowering effect and potentially worsen kidney function.
• Concomitant use with other blood pressure-lowering medications, especially ACE inhibitors (e.g., lisinopril, captopril) or aliskiren, may increase the risk of low blood pressure, kidney problems, and elevated potassium levels.
• Medicines that increase potassium levels, such as potassium supplements and potassium-sparing diuretics (e.g., amiloride, spironolactone), can lead to high potassium levels in the blood.
• Lithium, digoxin, insulin, oral anti-diabetic drugs, cholestyramine, colestipol, cimetidine, rifampicin, itraconazole, and miconazole may also interact.
• Avoid grapefruit juice, as it may increase the levels of this medicine in the body.

What precautions should be taken while on TRINEXOVAS 20 TABLET?

• Do not stop taking TRINEXOVAS 20 TABLET abruptly without consulting your doctor, as this can lead to a sudden rise in blood pressure and increase the risk of heart-related complications.
• Exercise caution if you have liver or kidney problems; this medicine is not recommended for severe liver or kidney disease.
• Patients with certain heart conditions such as low blood pressure (hypotension), cardiogenic shock, or aortic stenosis should use this medicine with caution.
• Regular monitoring of blood pressure, kidney function, electrolyte levels, and blood sugar levels is important during treatment.
• Since TRINEXOVAS 20 TABLET can cause dizziness or fatigue, avoid driving or operating heavy machinery until you know how the medicine affects you.
• Limit or avoid alcohol consumption, as it can increase the risk of side effects like dizziness.
• TRINEXOVAS 20 TABLET is not recommended for use in children under 18 years of age.
• Elderly patients (65 years and above) should use this medicine with caution and under medical supervision.

What happens if a dose of TRINEXOVAS 20 TABLET is missed?

If you miss a dose of TRINEXOVAS 20 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should TRINEXOVAS 20 TABLET be stored?

TRINEXOVAS 20 TABLET should be stored at room temperature, typically below 30°C or between 20-25°C. Keep it away from direct sunlight, heat, and moisture. Always ensure the medicine is kept out of the reach of children and pets.