Letpro 2.5mg Tab

LETPRO 2.5MG Tablet by ARISTO PHARMA is a medication primarily used in the treatment of breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors.

Name

• Brand Name: LETPRO 2.5MG Tablet
• Common Name: Letrozole 2.5mg Tablet

Composition

• Active Ingredient: Letrozole (2.5mg)

Uses

LETPRO 2.5MG Tablet is prescribed for:

• Breast Cancer:
  • Treatment of hormone-sensitive breast cancer in postmenopausal women, either alone or with other treatments like surgery or radiation.
  • Reducing the risk of cancer recurrence and supporting long-term recovery after initial treatment.
  • Halting the spread of advanced breast cancer to other parts of the body.
  • Used as first-line therapy, supportive therapy, or extended supportive therapy after other treatments like tamoxifen.
• Infertility:
  • Management of infertility due to anovulation (failure to ovulate) in women, by stimulating hormone release for egg development and ovulation.

Dosage and Administration

• The typical adult dosage for breast cancer is one 2.5mg tablet once daily, preferably at the same time each day.
• It can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• The duration of treatment is as advised by the doctor, often long-term for at least 5 years for breast cancer.
• For infertility, it may be taken once daily for 5 days from the third day of the menstrual cycle, with potential dosage increases if needed.

Side Effects

Common Side Effects:

• Hot flushes, increased sweating, night sweats.
• Fatigue, dizziness, headache, weakness.
• Joint pain, bone pain, back pain, muscle pain.
• Nausea, vomiting, diarrhea, constipation, abdominal pain.
• Weight gain, swelling (edema) of arms, hands, feet, ankles.
• High cholesterol (hypercholesterolemia).
• Hair loss or thinning.
• Skin rash, dry skin.
• Vaginal bleeding/spotting (usually in the first few weeks).
• Changes in appetite, difficulty sleeping, low mood, depression.

Serious Side Effects:

• Osteoporosis (thinning of bones) and increased risk of bone fractures.
• Blood clots (e.g., stroke, angina, heart attack, deep vein thrombosis).
• Cataracts.
• Severe skin reactions.
• Tendon inflammation or injury.
• Cardiac events.

Precautions

• Pregnancy and Breastfeeding: Highly unsafe and contraindicated during pregnancy and breastfeeding. Effective contraception should be used during treatment and for at least 3 weeks after the last dose.
• Driving and Operating Machinery: May cause dizziness or drowsiness; avoid these activities until you know how the medicine affects you.
• Alcohol: Caution is advised; alcohol may intensify drowsiness and dizziness.
• Liver Disease: Use with caution in patients with liver disease, and liver function may need monitoring.
• Kidney Disease: Generally safe but caution is advised; consult a doctor.
• Bone Health: May cause bone loss (osteoporosis). Bone mineral density (BMD) may be monitored before, during, and after treatment.
• High Cholesterol: May increase cholesterol levels; monitoring is recommended.
• Other Medications: Avoid concomitant use with tamoxifen and estrogen-containing products (e.g., hormone replacement therapy, oral contraceptives). Use with caution with phenytoin and clopidogrel.
• Menopausal Status: Only intended for use in postmenopausal women.

Storage

• Store below 30°C or at room temperature, protected from direct sunlight, moisture, and heat.
• Keep out of reach of children and pets.
• Discard unused medicine properly.

Here are frequently asked questions about LETPRO 2.5MG Tablet:

What is LETPRO 2.5MG Tablet used for?

LETPRO 2.5MG Tablet, containing Letrozole, is primarily used for the treatment of breast cancer in postmenopausal women. It can be used as an initial therapy, as supportive therapy after other treatments like tamoxifen, or for advanced breast cancer to prevent tumor spread. Additionally, it is used in women with infertility due to anovulation to induce ovulation.

How does LETPRO 2.5MG Tablet work?

LETPRO 2.5MG Tablet belongs to a class of medications called aromatase inhibitors. It works by blocking the enzyme aromatase, which is responsible for producing estrogen in the body. Since the growth of certain breast cancers is stimulated by estrogen, reducing estrogen levels helps to slow down or stop the growth and spread of these cancer cells. For infertility, the reduction in estrogen levels prompts the release of hormones (FSH and LH) that stimulate egg production and ovulation.

What is the usual dosage for LETPRO 2.5MG Tablet?

The typical dosage is 2.5 mg taken once daily. It can be taken with or without food, but it is recommended to take it at the same time each day for best results. The tablet should be swallowed whole with a glass of water; do not crush, chew, or break it. Your doctor will determine the appropriate dosage and duration of treatment based on your specific condition.

What are the possible side effects of LETPRO 2.5MG Tablet?

Common side effects can include hot flashes, increased sweating, fatigue, joint pain (arthralgia), dizziness, bone pain, high cholesterol (hypercholesterolemia), swelling (edema), flushing, nausea, vomiting, and headache. More serious but less common side effects can involve decreased bone mineral density (leading to osteoporosis and increased fracture risk), decreased red blood cells, and potential for blood clots.

Is LETPRO 2.5MG Tablet safe during pregnancy or breastfeeding?

No, LETPRO 2.5MG Tablet is contraindicated during pregnancy and breastfeeding. It is highly unsafe during pregnancy as studies have shown significant harmful effects on the developing baby. It is also unsafe during breastfeeding as it may cause toxicity to the infant. This medication should only be used by postmenopausal women for breast cancer treatment. Pre-menopausal women taking this medication for other conditions should use effective birth control during treatment and for at least three weeks after the last dose.

Can LETPRO 2.5MG Tablet be taken with other medications?

It is crucial to inform your doctor about all prescribed medications, over-the-counter medicines, herbal products, and vitamin supplements you are taking. LETPRO 2.5MG Tablet should generally not be taken with estrogen-containing medications, such as hormone replacement therapy or oral contraceptives, as these can reduce its effectiveness. Concomitant use with tamoxifen is also usually avoided. Caution is advised with antidepressants (like citalopram, escitalopram), phenytoin, clopidogrel, anticoagulants, NSAIDs, and St. John's Wort due to potential interactions.

What precautions should be taken while taking LETPRO 2.5MG Tablet?

You should inform your doctor if you have a history of liver or kidney problems, osteoporosis, or bone fractures, as these conditions may require careful monitoring or dosage adjustments. Regular monitoring of bone mineral density and cholesterol levels may be performed. Since LETPRO 2.5MG Tablet can cause drowsiness and dizziness, it's advisable to avoid driving or operating machinery until you know how the medication affects you. Alcohol consumption should be approached with caution as it may intensify these side effects. Report any signs of tendon pain or swelling to your doctor.

What happens if a dose of LETPRO 2.5MG Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should LETPRO 2.5MG Tablet be stored?

LETPRO 2.5MG Tablet should be stored at room temperature, typically not exceeding 25°C or 30°C. Keep the medicine away from direct light, moisture, and heat. Always ensure it is stored in a place out of reach of children and pets. Check the expiry date before using.