GLISEN VM 2 MG TABLET

Name

• Brand Name: GLISEN VM 2 MG TABLET
• Common Name: Glimepiride, Metformin, and Voglibose combination tablet

Composition

GLISEN VM 2 MG TABLET contains a combination of three active ingredients:

• Glimepiride: 2 mg
• Metformin Hydrochloride: 500 mg
• Voglibose: 0.2 mg

Uses

GLISEN VM 2 MG TABLET is prescribed for adults to manage Type 2 Diabetes Mellitus. It is used when diet, exercise, and therapy with one or two other anti-diabetic medicines are not sufficient to adequately control blood sugar levels. This medication helps regulate glucose metabolism, improve insulin sensitivity, and prevent post-meal blood sugar spikes, thereby reducing the risk of long-term diabetes complications such as kidney damage, nerve damage, and vision problems.

Dosage and Administration

Take GLISEN VM 2 MG TABLET orally as advised by your physician. It should be swallowed whole with a glass of water and not crushed, chewed, or broken. The tablet is typically taken with or immediately before meals to minimize gastrointestinal discomfort and ensure proper absorption. Your doctor will determine the appropriate dose and frequency, which may vary based on your condition and blood sugar levels. It is important to take the medicine regularly at the same time each day for optimal results and not to discontinue it abruptly without consulting your doctor.

Side Effects

Common Side Effects:

• Nausea, vomiting
• Diarrhea, abdominal pain, stomach discomfort
• Loss of appetite
• Metallic taste
• Hypoglycemia (low blood sugar), characterized by dizziness, sweating, hunger pangs, headache, irritability, shaking, and dry mouth and skin
• Changes in taste
• Upper respiratory symptoms or infection
• Flatulence
• Edema (swelling)
• Blurred vision
• Bone fracture
• Weight gain

Serious Side Effects:

• Lactic acidosis (excess lactic acid in the blood)
• Severe hypoglycemia
• Allergic reactions

Precautions

• Pregnancy and Breastfeeding: Not recommended for use in pregnant or breastfeeding women as it may harm the fetus or nursing child.
• Children and Adolescents: Not recommended for use in individuals below 18 years of age.
• Elderly Patients: Use with caution in elderly patients (aged 75 years or older) after consulting a doctor.
• Pre-existing Medical Conditions: Avoid if allergic to any components. Contraindicated in Type 1 Diabetes Mellitus, diabetic ketoacidosis, acute metabolic acidosis, severe kidney or liver disease, severe infection, dehydration, severe ketosis, severe trauma, lung problems, heart problems (like heart failure or recent myocardial infarction).
• Alcohol Consumption: Avoid or limit alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis.
• Diet and Exercise: This medicine works best when combined with a healthy diet and regular exercise.
• Hypoglycemia: Carry a fast-acting source of glucose (e.g., sugary food or fruit juice) to manage low blood sugar levels. Do not skip meals.
• Monitoring: Regular monitoring of blood sugar levels is crucial. Your doctor may also advise blood tests to monitor liver function.
• Drug Interactions: Inform your doctor about all current medications as certain drugs (e.g., some antibacterials, antifungals, NSAIDs, thyroid medications) can interact with GLISEN VM 2 MG TABLET.

Storage

Store GLISEN VM 2 MG TABLET in a cool and dry place, away from direct sunlight, at room temperature (below 30°C, typically between 10°C to 25°C). Keep it out of sight and reach of children and pets.

Here are some frequently asked questions about GLISEN VM 2 MG TABLET (10 TAB) by ALEMBIC PHARMACEUTICALS LIMITED, along with their answers:

What is GLISEN VM 2 MG TABLET used for?

GLISEN VM 2 MG TABLET is primarily used in adults to manage Type 2 Diabetes Mellitus. It helps control high blood sugar levels when diet, exercise, and therapy with one or two other antidiabetic drugs are not sufficient. By effectively managing blood sugar, it helps reduce the risk of serious diabetes-related complications such as kidney damage, eye damage, nerve problems, heart attack, and stroke.

How does GLISEN VM 2 MG TABLET work?

This medicine is a combination of three active ingredients: Glimepiride, Metformin, and Voglibose.

• Glimepiride is a sulfonylurea that works by stimulating the pancreas to release more insulin, which helps lower blood glucose.
• Metformin is a biguanide that reduces the production of glucose by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, allowing cells to use glucose more effectively.
• Voglibose is an alpha-glucosidase inhibitor that slows down the digestion and absorption of complex carbohydrates from the intestines, especially after meals. This prevents a sharp rise in blood sugar levels following food intake.

What is the usual dosage for GLISEN VM 2 MG TABLET?

The dosage of GLISEN VM 2 MG TABLET is highly individualized and should be strictly followed as prescribed by your doctor. It is typically taken orally with food to minimize stomach upset. The tablet should be swallowed whole with water and not crushed, chewed, or broken.

What are the possible side effects of GLISEN VM 2 MG TABLET?

Common side effects may include hypoglycemia (low blood sugar), nausea, diarrhea, stomach pain, altered taste, headache, flatulence, loss of appetite, and upper respiratory tract infections. More serious but rare side effects can include lactic acidosis (symptoms like extreme fatigue, body weakness, difficulty breathing, abdominal pain, muscle pain, reduced body temperature, and slow heart rate) and, with long-term use, Vitamin B12 deficiency. If you experience severe or persistent side effects, contact your doctor immediately.

Is GLISEN VM 2 MG TABLET safe during pregnancy or breastfeeding?

GLISEN VM 2 MG TABLET is generally not recommended and may be unsafe to use during pregnancy, as it could harm the developing fetus. Similarly, it is probably unsafe during breastfeeding, as its components may pass into breast milk and potentially affect the nursing infant. Always consult your doctor for alternative treatment options if you are pregnant or breastfeeding.

Can GLISEN VM 2 MG TABLET be taken with other medications?

GLISEN VM 2 MG TABLET can interact with various other medications. Inform your doctor about all prescription drugs, over-the-counter medicines, supplements, and herbal products you are currently taking. Interactions can occur with other antidiabetic medications (increasing the risk of hypoglycemia), certain antibiotics, antifungals, blood pressure medications (e.g., ACE inhibitors), painkillers (e.g., diclofenac, ibuprofen), water pills, and anti-clotting medications. Alcohol consumption should be avoided as it significantly increases the risk of hypoglycemia and lactic acidosis.

What precautions should be taken while using GLISEN VM 2 MG TABLET?

Do not stop taking this medicine abruptly without consulting your doctor. Regular monitoring of blood sugar levels is crucial. Always carry a fast-acting source of glucose (like sugary food or fruit juice) to treat potential low blood sugar episodes. Maintain a balanced diet and engage in regular exercise as advised by your doctor. Inform your doctor if you have a history of kidney, liver, or heart disease, pancreatitis, or low Vitamin B12 levels, as these conditions may affect its suitability or require dosage adjustments. Be cautious when driving or operating machinery, as fluctuations in blood sugar can cause dizziness or blurred vision.

What happens if a dose of GLISEN VM 2 MG TABLET is missed?

If you miss a dose of GLISEN VM 2 MG TABLET, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should GLISEN VM 2 MG TABLET be stored?

Store GLISEN VM 2 MG TABLET in a cool, dry place, typically below 25°C or 30°C, away from direct sunlight, moisture, and light. Keep the medicine out of the sight and reach of children.