Histafree M Susp

HISTAFREE M SUSP

HISTAFREE M SUSP is an anti-allergic medication manufactured by Mankind Pharma Ltd., primarily used to relieve symptoms associated with various allergic conditions and asthma.

• Name

  • Brand Name: Histafree M Suspension, Histafree M Oral Suspension, Histafree M Mango Flavour Oral Suspension.
  • Common Name: Montelukast and Fexofenadine Oral Suspension.

• Composition

  • HISTAFREE M SUSP contains a combination of two active ingredients:
    • Montelukast: 4 mg/5ml (a leukotriene receptor antagonist)
    • Fexofenadine: 60 mg/5ml (an antihistamine) These work synergistically to block the action of leukotrienes and histamine, chemicals in the body responsible for causing swelling, inflammation, and allergic reactions.

• Uses HISTAFREE M SUSP is prescribed for the treatment and management of various allergic and respiratory conditions, including:

  • Allergic Rhinitis (seasonal and perennial)
  • Allergic symptoms such as sneezing, runny nose, congestion, stuffy nose, itchy/watery eyes, and itchy nose or throat
  • Chronic Idiopathic Urticaria (hives or chronic skin allergies with itching, redness, and swelling)
  • Prevention and long-term treatment of asthma

• Dosage and Administration

  • Shake the suspension well before use.
  • Administer orally as directed by a healthcare professional, using a measuring cup or spoon.
  • It can be taken with or without food.
  • Avoid taking it with fruit juices (e.g., grapefruit, orange, apple) as they may interfere with the absorption of Fexofenadine.
  • Typical Dosage Guidance for Children:
    • 2-5 years: 2.5 ml twice daily.
    • 6-11 years: 5 ml twice daily.
  • For asthma, it may be preferred in the evening or 2 hours before physical activity. For allergies, dosage timing depends on symptom onset.
  • Do not exceed the prescribed dose.

• Side Effects Common side effects may include:

  • Drowsiness
  • Headache
  • Nausea
  • Diarrhea
  • Vomiting
  • Dizziness
  • Skin rash
  • Fever
  • Stomach pain
  • Fatigue/Tiredness Serious side effects, though rare, can include mental health changes such as agitation and depression.

• Precautions

  • Allergy: Do not use if there is a known hypersensitivity or allergy to Montelukast, Fexofenadine, or any other components of the suspension.
  • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.
  • Alcohol: Avoid or limit alcohol consumption as it may increase drowsiness.
  • Driving/Operating Machinery: As this medicine may cause dizziness or drowsiness, exercise caution when driving or operating heavy machinery until you know how it affects you.
  • Medical Conditions: Use with caution in patients with liver or kidney impairment. Inform your doctor about any pre-existing medical conditions, especially liver disease, kidney disease, or a history of mental health issues.
  • Drug Interactions: Inform your doctor about all other medications, supplements, or herbal products you are taking. Maintain a 2-hour gap between HISTAFREE M SUSP and indigestion remedies containing magnesium and aluminum. Possible interactions with medications such as phenytoin, rifampicin, and fluconazole may occur.
  • Children: HISTAFREE M SUSP is not recommended for children below 12 years for general use, although it is commonly prescribed for allergy symptoms in children. Dosing must be carefully monitored based on age and weight, following the doctor's instructions.

• Storage

  • Store in a cool, dry place away from direct sunlight, heat, and moisture.
  • Keep at room temperature, ideally between 10ºC to 25ºC or below 30ºC.
  • Keep out of the sight and reach of children.

HISTAFREE M SUSP is a combination medicine manufactured by Mankind Pharma Ltd. It contains two active ingredients: Montelukast and Fexofenadine.

What is HISTAFREE M SUSP used for?

HISTAFREE M SUSP is primarily used to treat allergic symptoms such as sneezing, runny nose, congestion, stuffy nose, itchy or watery eyes, and allergic skin conditions like urticaria (hives). It is effective for allergic rhinitis (hay fever), seasonal and perennial allergies, and also helps in the management of asthma by reducing inflammation in the airways.

How does HISTAFREE M SUSP work?

This suspension works through the combined action of its two active ingredients:

• Fexofenadine: This is an antihistamine that blocks the action of histamine, a chemical in the body responsible for causing allergic reactions like sneezing, runny nose, and itchy eyes.
• Montelukast: This is a leukotriene receptor antagonist. It works by blocking the action of chemicals called leukotrienes, which are released from the lungs and cause inflammation (swelling), increased mucus production, and narrowing of the airways. By blocking leukotrienes, it reduces inflammation and improves breathing.

What is the usual dosage?

The dosage of HISTAFREE M SUSP is determined by a doctor based on age, medical condition, and response to treatment. For children aged 2-5 years, a typical dose might be 2.5 ml twice daily. For children aged 6-11 years, 5 ml twice daily is common. It should be taken orally as directed by your healthcare provider, often at a fixed time each day. It can be taken with or without food, but avoid taking it with fruit juices as they may affect absorption. Do not exceed the prescribed dose.

What are the possible side effects?

Common side effects may include drowsiness, headache, dizziness, nausea, vomiting, diarrhea, stomach pain, skin rash, and fever. More serious, though rare, side effects can include mental health changes such as agitation and depression. If any side effects persist or worsen, consult your doctor.

Is it safe during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, it is advised to inform your doctor before using HISTAFREE M SUSP. While some information suggests Fexofenadine might be safe during breastfeeding, and generally considered safe in pregnancy with limited studies, your doctor will weigh the benefits against potential risks before prescribing it.

Can it be taken with other medications?

HISTAFREE M SUSP can interact with certain medications. For example, antacids containing magnesium and aluminum should be taken with at least a 2-hour gap, as they may reduce the absorption of HISTAFREE M SUSP. Inform your doctor about all medications, supplements, or herbal products you are taking to prevent potential drug interactions. Avoid combining it with other cold and flu medicines without consulting a doctor.

What precautions should be taken?

• Avoid alcohol consumption as it may increase drowsiness.
• Histafree M SUSP may cause dizziness or drowsiness, so drive or operate machinery only if you are alert.
• Use with caution in patients with liver or kidney diseases; dosage adjustments may be necessary. Inform your doctor if you have a history of mental health issues due to the risk of neuropsychiatric events.
• It is not recommended for children below 12 years of age for some indications. Dosing for children should be carefully monitored based on age and weight.

What happens if a dose is missed?

If a dose is missed, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

HISTAFREE M SUSP should be stored in a cool and dry place, away from direct sunlight, heat, and moisture. Keep it out of the sight and reach of children. It should typically be stored at room temperature (10°C to 30°C).