Macrozide 750mg Tab

MACROZIDE 750MG Tablet is a medication manufactured by Macleods Pharmaceuticals Ltd., primarily used in the treatment of tuberculosis.

Name

• Brand Name: MACROZIDE 750MG TAB
• Common Name: Pyrazinamide 750mg Tablet (based on active ingredient)

Composition

• Active Ingredients: Pyrazinamide (750mg)

Uses

MACROZIDE 750MG Tablet is primarily used for the following conditions:

• Tuberculosis (TB): It is used to treat and prevent tuberculosis, an infectious disease that mainly affects the lungs but can also spread to other body parts like kidneys, brain, spine, and bone marrow.
• It is often used as part of combination therapy, especially in the initial phase of TB treatment, to shorten the overall treatment duration and enhance effectiveness. It has both bacteriostatic (stops growth) and bactericidal (kills bacteria) actions against Mycobacterium tuberculosis.

Dosage and Administration

• Typical Guidance: MACROZIDE 750MG Tablet is usually taken once daily, with or without food, or as advised by a doctor.
• Administration: The tablet should be swallowed whole and not chewed or crushed, unless advised by a healthcare provider.
• Duration: Patients should complete the full course of treatment as prescribed, even if they start feeling better, to prevent the infection from returning or worsening. A common course duration is 2 months for tuberculosis, with a single maximum dose of 30 mg/kg.

Side Effects

Common Side Effects:

• Muscle/joint pain (arthralgia)
• Nausea, vomiting
• Loss of appetite (anorexia)
• Skin rash or irritation, itching, photosensitivity
• Gastrointestinal discomfort such as indigestion
• Unusual tiredness and weakness
• Dizziness, headache, flushing

Serious Side Effects:

• Liver Damage: Elevated liver enzymes, hepatitis (viral infection of liver), jaundice (yellowing of eyes or skin, dark urine, stomach pain). Regular monitoring of liver function tests is advised.
• Gout/Hyperuricemia: Pyrazinamide can increase blood uric acid levels (hyperuricemia) which can lead to gout symptoms like joint pain, swelling, redness, and stiffness.

Precautions

• Allergies: Not recommended for patients with a known allergy to Pyrazinamide or its components.
• Liver Impairment: Not recommended in patients with severe liver damage or active liver disease. Liver function should be monitored.
• Kidney Impairment: Use with caution in patients with severe kidney disease; dose adjustment may be needed, and kidney function tests are advised.
• Gout: Not recommended in patients with increased uric acid levels or acute gout.
• Alcohol Consumption: Avoid consuming alcohol as it might lead to liver problems and increase the risk of side effects.
• Pregnancy and Breastfeeding: Use with caution. It is generally not recommended during pregnancy unless absolutely necessary, and only if the potential benefits outweigh the risks. It is excreted into breast milk and may harm a nursing baby, so it is recommended only if clearly needed.
• Drug Interactions: Inform your doctor about all prescription and non-prescription medications, including other antitubercular agents, vitamins, herbal, and complementary medicines. It can interact with medications like Methotrexate, increasing the risk of liver injury.
• Vaccinations: Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (e.g., typhoid vaccine) as MACROZIDE may affect their activity.

Storage

• Store below 25°C or at room temperature, away from direct sunlight, moisture, and the reach of children.
• Keep it in a tightly closed container.
• Check the expiration date regularly and dispose of unused or expired medication properly.

MACROZIDE 750MG TAB by MACLEODS PHARMACEUTICALS LTD is a medication primarily used in the treatment of tuberculosis (TB). It contains the active ingredient Pyrazinamide.

What is MACROZIDE 750MG TAB used for?

MACROZIDE 750MG TAB is used to treat and prevent tuberculosis (TB), an infectious disease that primarily affects the lungs but can also spread to other parts of the body such as the kidneys, brain, spine, and bone marrow. It is typically used as part of a combination therapy with other anti-tubercular agents to shorten the treatment duration and enhance effectiveness.

How does MACROZIDE 750MG TAB work?

The active ingredient, Pyrazinamide, is a bacteriocidal antibiotic. It works by converting into pyrazinoic acid (POA) within the body. This pyrazinoic acid inhibits the synthesis of fatty acids in the Mycobacterium tuberculosis bacteria, disrupting their cell membrane, disabling energy production, and lowering the pH within the bacteria, which ultimately leads to their destruction.

What is the usual dosage for MACROZIDE 750MG TAB?

MACROZIDE 750MG TAB is typically taken orally in tablet form, once daily. It can be taken with or without food, but some sources suggest taking it after food. The recommended dose is usually 15 to 30 mg/kg once daily, and the treatment duration can be around two months in the initial phase of TB therapy. It is crucial to follow the doctor's instructions regarding the dosage and duration of treatment and not to crush or chew the tablets unless advised.

What are the possible side effects of MACROZIDE 750MG TAB?

Common side effects include nausea, vomiting, loss of appetite, muscle/joint pain, and headache. More serious side effects can include liver toxicity (hepatitis, increased liver enzymes, jaundice), which may manifest as yellowing of the skin or eyes, dark urine, or abdominal pain. Macrozide can also increase uric acid levels, potentially leading to gout.

Can MACROZIDE 750MG TAB be taken during pregnancy or breastfeeding?

Pregnancy: MACROZIDE 750MG TAB may be unsafe to use during pregnancy, and some sources indicate it can cause severe side effects if taken. Limited human data and animal studies have shown harmful effects on the developing baby. It should only be used if the benefits outweigh the risks, and consultation with a doctor is necessary.

Breastfeeding: The safety of MACROZIDE 750MG TAB during breastfeeding is generally considered with caution. Some sources suggest it is probably safe due to limited human data indicating no significant risk to the baby, while others advise caution as it is excreted into breast milk and may harm a nursing baby. It is recommended to consult a doctor if breastfeeding.

Can MACROZIDE 750MG TAB be taken with other medications?

MACROZIDE 750MG TAB can interact with other medications. It can increase the risk of liver damage when taken with other drugs that affect the liver, such as acetaminophen or methotrexate. It can also increase uric acid levels, so caution is advised with medications for gout. Oral contraceptive pills may become less effective when taken with MACROZIDE 750MG TAB, necessitating the use of alternative contraception methods. Always inform your doctor about all medicines you are taking to prevent interactions.

What precautions should be taken while taking MACROZIDE 750MG TAB?

Before taking MACROZIDE 750MG TAB, inform your doctor if you have allergies, kidney or liver disease, diabetes, or gout, or if you are pregnant or breastfeeding. Regular monitoring of liver function and uric acid levels is recommended during treatment due to the risk of liver toxicity and gout. Avoid alcohol consumption as it can increase the risk of liver damage and other side effects.

What happens if a dose of MACROZIDE 750MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose. It is important not to skip any doses and to complete the full course of treatment as prescribed.

How should MACROZIDE 750MG TAB be stored?

MACROZIDE 750MG TAB should be stored at room temperature, below 25°C or 30°C, away from moisture and direct sunlight. Keep it in a tightly closed container and out of the reach of children. Check the expiration date regularly and properly dispose of any unused or expired medication.