Ezact 60 Mg ( 10 Tablet )

EZACT 60 MG (10 TABLET) by SUN PHARMA LABORATORIES LTD.

Name

• Brand Name: EZACT 60 MG
• Common Name: Etoricoxib

Composition EZACT 60 MG contains Etoricoxib 60 mg as its active ingredient. Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, a type of non-steroidal anti-inflammatory drug (NSAID). It works by blocking the production of prostaglandins, chemicals in the body responsible for pain and inflammation.

Uses EZACT 60 MG is primarily prescribed for the relief of pain and inflammation associated with various conditions, including:

• Osteoarthritis
• Rheumatoid Arthritis
• Ankylosing Spondylitis
• Gout (acute gouty arthritis)
• Acute pain, such as post-surgical pain (e.g., after dental surgery)
• Chronic low back pain
• Dysmenorrhea (painful menstruation)

Dosage and Administration The recommended dose of EZACT 60 MG should be taken orally as directed by a healthcare provider, typically once daily. It can be taken with or without food, though taking it without food may enhance its effectiveness. Do not exceed the prescribed dosage. It is not recommended for children below 16 years of age.

Side Effects Common side effects may include:

• Upset stomach, indigestion (dyspepsia), stomach pain
• Nausea, vomiting, diarrhea, constipation
• Headache, dizziness
• High blood pressure, palpitations
• Swelling of the legs or feet (edema)
• Flu-like symptoms, weakness

Serious side effects, though less common, can include an increased risk of heart attack, stroke, kidney or liver problems, and gastrointestinal bleeding or ulcers. Seek immediate medical attention if serious side effects occur.

Precautions

• Cardiovascular Risk: EZACT 60 MG may increase the risk of heart attack or stroke, especially in patients with pre-existing cardiovascular disease, high blood pressure, diabetes, or high cholesterol.
• Gastrointestinal Disorders: Caution is advised for patients with a history of ulcers or gastrointestinal bleeding, as this medicine may increase the risk of recurrence.
• Kidney and Liver Conditions: Use with caution in patients with kidney or liver disease.
• Pregnancy and Breastfeeding: Should generally be avoided during the third trimester of pregnancy and is considered unsafe during breastfeeding. Consult a doctor before use.
• Drug Interactions: Inform your doctor about all medications you are taking. Interactions can occur with anticoagulants (e.g., warfarin), ACE inhibitors, diuretics, methotrexate, and high doses of aspirin. Low-dose aspirin for heart attack/stroke prevention should not be discontinued without consulting a doctor.
• Alcohol: Avoid consuming alcohol as it may increase the risk of adverse effects.

Storage Store EZACT 60 MG tablets in a tightly sealed container at room temperature, ideally between 15°-30°C or below 30°C. Keep it away from excess moisture, direct light, and out of reach of children.

Here are frequently asked questions and answers about EZACT 60 MG tablets, which contain the active ingredient Etoricoxib.

What is EZACT 60 MG used for?

EZACT 60 MG (Etoricoxib) is a non-steroidal anti-inflammatory drug (NSAID) used for the symptomatic relief of pain and inflammation. It is prescribed for conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, and for the short-term treatment of moderate pain following dental surgery.

How does EZACT 60 MG work?

EZACT 60 MG works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme. This enzyme is responsible for producing prostaglandins, which are chemical messengers that cause pain, swelling, and inflammation in the body. By blocking COX-2, Etoricoxib reduces the production of these prostaglandins, thereby alleviating pain and inflammation. Its selective action on COX-2 may lead to a lower risk of gastrointestinal side effects compared to traditional non-selective NSAIDs.

What is the usual dosage for EZACT 60 MG?

The dosage of EZACT 60 MG depends on the condition being treated and should always be followed as prescribed by your doctor.

• For Osteoarthritis: The recommended dose is typically 30 mg once daily, which can be increased to 60 mg once daily if needed for insufficient relief. The maximum dose for osteoarthritis should not exceed 60 mg daily.
• For Rheumatoid Arthritis and Ankylosing Spondylitis: The recommended dose is 60 mg once daily. It may be increased to 90 mg once daily if necessary, and then potentially reduced back to 60 mg once daily once stable.
• For Acute Gouty Arthritis: The recommended dose is 120 mg once daily, limited to a maximum of 8 days of treatment.
• For Postoperative Dental Surgery Pain: The recommended dose is 90 mg once daily, limited to a maximum of 3 days.

It is important to use the lowest effective dose for the shortest possible duration due to potential cardiovascular risks.

What are the possible side effects of EZACT 60 MG?

Common side effects may include dizziness, headache, stomach pain, nausea, vomiting, diarrhea, constipation, indigestion, gas, and swelling (edema). More serious, though less common, side effects can include severe allergic reactions (such as rash, itching, swelling of the face, lips, or tongue, or difficulty breathing), increased blood pressure, stomach ulcers or bleeding, liver problems (yellowing of skin/eyes), kidney problems, or an increased risk of heart attack or stroke. If you experience any severe symptoms, seek immediate medical attention.

Is EZACT 60 MG safe during pregnancy or breastfeeding?

EZACT 60 MG (Etoricoxib) is contraindicated during pregnancy. If you become pregnant while taking this medicine, you must discontinue it and inform your doctor immediately, as it may cause harm to the unborn child, particularly affecting the heart and kidneys in the later stages of pregnancy. It is unknown whether Etoricoxib is excreted in human breast milk. Therefore, women taking EZACT 60 MG should not breastfeed. The use of Etoricoxib is also not recommended in women attempting to conceive.

Can EZACT 60 MG be taken with other medications?

EZACT 60 MG can interact with several medications. It is crucial to inform your doctor or pharmacist about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking.

• Avoid taking EZACT 60 MG with other NSAIDs (like ibuprofen or naproxen) or high-dose aspirin, as this increases the risk of serious side effects such as gastrointestinal bleeding and cardiovascular events.
• If you are on low-dose aspirin for cardiovascular protection, you can generally continue it with EZACT 60 MG, but the risk of gastrointestinal issues may be increased.
• Caution is advised when taken with blood thinners (anticoagulants like warfarin), diuretics, ACE inhibitors, or Angiotensin II receptor blockers, as these combinations can increase the risk of bleeding or reduce the effectiveness of blood pressure medications and potentially worsen kidney function.
• EZACT 60 MG may also interact with medications like methotrexate, cyclosporine, tacrolimus, oral contraceptives, and certain antidepressants (SSRIs/SNRIs).

What precautions should be taken with EZACT 60 MG?

Before taking EZACT 60 MG, tell your doctor if you have any history of heart disease (including heart attack, stroke, high blood pressure, or heart failure), kidney or liver problems, stomach ulcers or bleeding, asthma, diabetes, or high cholesterol. Blood pressure should be monitored regularly, especially within the first two weeks of starting treatment. Avoid alcohol consumption as it may increase the risk of stomach bleeding and drowsiness. If you experience dizziness or drowsiness, avoid driving or operating machinery. Do not take EZACT 60 MG if you have a known allergy to Etoricoxib, aspirin, or other NSAIDs. It should not be used immediately before or after coronary artery bypass graft (CABG) surgery.

What happens if a dose of EZACT 60 MG is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten tablet.

How should EZACT 60 MG be stored?

Store EZACT 60 MG in its original package to protect it from moisture. It generally does not require any special storage conditions but should be kept in a cool and dry place, typically below 30°C (or between 10°C and 25°C), away from direct sunlight. Keep the medicine out of the sight and reach of children.