Justoza Sm 500mg Tab

JUSTOZA SM 500MG TABLET

JUSTOZA SM 500MG Tablet, manufactured by Mankind Pharma Ltd., is a combination medication prescribed for the management of Type 2 Diabetes Mellitus in adults.

• Name

  • Brand Name: JUSTOZA SM 500MG TABLET
  • Common Names of Active Ingredients: Dapagliflozin, Metformin, Sitagliptin

• Composition Each tablet contains:

  • Dapagliflozin: 10 mg
  • Metformin Hydrochloride: 500 mg (sustained release)
  • Sitagliptin: 100 mg (as Sitagliptin Phosphate)

• Uses JUSTOZA SM 500MG Tablet is used to improve blood sugar control in adults with Type 2 Diabetes Mellitus. It is typically prescribed when diet and exercise alone are insufficient, or when metformin alone or dual therapy with metformin and either dapagliflozin or sitagliptin is inadequate. This medication works by:

  • Decreasing glucose production in the liver.
  • Improving the body's sensitivity to insulin.
  • Increasing the release of insulin from the pancreas and decreasing glucagon secretion.
  • Removing excess sugar from the body through urine. It also helps to reduce the risk of serious complications associated with diabetes, such as kidney damage, nerve problems, loss of limbs, and may offer cardiovascular and kidney protection, as well as support weight loss in some individuals.

• Dosage and Administration The typical dosage for adults is one tablet taken orally, usually once or twice daily. It is recommended to take the tablet with meals to minimize gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed or chewed. It is crucial to follow the physician's instructions precisely regarding dosage and timing, and not to stop the medication without consulting the doctor.

• Side Effects

  • Common Side Effects: Nausea, vomiting, diarrhea, stomach pain, loss of appetite, metallic taste, headache, dizziness, fatigue, constipation, heartburn, bloating, changes in blood sugar levels, genital infections (fungal), urinary tract infection, nasopharyngitis (inflammation of the throat and nasal passages), increased or more frequent urination, flatulence, dry mouth, decreased weight, thirst, back pain, cough, and influenza.
  • Serious Side Effects (seek immediate medical attention if experienced):
    • Lactic acidosis (symptoms include muscle pain/cramps, rapid breathing, stomach pain, feeling cold or uncomfortable, severe nausea or vomiting).
    • Severe allergic reactions (rash, hives, blisters on the skin, peeling skin, swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing).
    • Acute pancreatitis (severe and persistent abdominal pain that might radiate through the back with or without nausea and vomiting).
    • Signs of bullous pemphigoid (blistering of the skin).
    • Hypoglycemia (low blood sugar) if taken with other antidiabetic medicines or if a meal is skipped.

• Precautions

  • Inform your doctor about any pre-existing medical conditions, especially kidney or liver disease, respiratory failure, heart failure, severe infection, or a history of pancreatitis.
  • Not recommended for use in patients with Type 1 Diabetes Mellitus, severe kidney impairment (including end-stage renal disease or dialysis), severe liver disease, acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis), or diabetic pre-coma.
  • Avoid or limit alcohol consumption, as it can increase the risk of lactic acidosis.
  • Pregnant or breastfeeding women should consult their doctor before taking this medicine. It is generally not recommended during pregnancy or breastfeeding.
  • Inform your doctor about all other medications you are taking, including herbal supplements, as interactions can occur (e.g., with insulin, sulfonylureas, diuretics, NSAIDs, ACE inhibitors).
  • If you are scheduled for any surgery or medical procedure, inform your doctor that you are taking JUSTOZA SM 500MG Tablet.
  • Regular monitoring of blood sugar levels and kidney function is advisable during treatment.
  • Maintain a healthy lifestyle, including a balanced diet and regular exercise, while taking this medication. Stay adequately hydrated.

• Storage Store JUSTOZA SM 500MG Tablet in a cool, dry place, away from direct sunlight and moisture, and below 30°C. Keep it out of reach of children and pets.

Here are the most frequently asked questions about JUSTOZA SM 500MG Tablet:

What is JUSTOZA SM 500MG Tablet used for?

JUSTOZA SM 500MG Tablet is a combination medicine primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by metformin alone, or by dual therapy with metformin and either dapagliflozin or sitagliptin. This medication helps to improve blood sugar control, support weight loss, and reduce cardiovascular and kidney risks in certain patients with type 2 diabetes.

How does JUSTOZA SM 500MG Tablet work?

JUSTOZA SM 500MG Tablet contains three active ingredients: Dapagliflozin, Metformin, and Sitagliptin, which work together to control blood sugar levels.

• Dapagliflozin (10 mg) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by causing the kidneys to excrete more glucose through the urine, thereby reducing blood glucose levels.
• Metformin (500 mg) is a biguanide that decreases glucose production in the liver and reduces glucose absorption from the intestines. It also enhances the body's sensitivity to insulin, improving glucose uptake and utilization by muscles and tissues.
• Sitagliptin (100 mg) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the release of insulin from the pancreas and decreases the secretion of glucagon (a hormone that raises blood sugar), especially when blood sugar levels are high.

What is the usual dosage of JUSTOZA SM 500MG Tablet?

The dosage of JUSTOZA SM 500MG Tablet is determined by your doctor based on your individual needs, kidney function, and response to the medication. It is typically taken orally once or twice daily, usually with meals to minimize gastrointestinal side effects. It's crucial to follow your physician's instructions precisely and not to discontinue the medication without their guidance.

What are the possible side effects of JUSTOZA SM 500MG Tablet?

Common side effects of JUSTOZA SM 500MG Tablet may include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, genital fungal infections, headache, nausea, diarrhea, stomach pain, and a metallic taste in the mouth. Serious but rare side effects can include lactic acidosis, ketoacidosis, severe stomach pain (pancreatitis), and allergic reactions (rash, swelling, breathing problems). It is important to report any severe or persistent side effects to your healthcare provider immediately.

Is it safe during pregnancy or breastfeeding?

JUSTOZA SM 500MG Tablet is generally not recommended for use during pregnancy or breastfeeding due to limited information on its effects in pregnant women and the presence of metformin in human breast milk. It is essential to inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medication.

Can it be taken with other medications?

JUSTOZA SM 500MG Tablet can interact with other medications. It is crucial to inform your doctor about all prescription, non-prescription, herbal, or supplement medications you are currently taking or plan to take. Particular care should be taken if you are taking diuretics (water pills), medicines for fungal infections (e.g., ketoconazole, clarithromycin), bacterial infections, HIV/AIDS (e.g., ritonavir), heart failure (e.g., digoxin), or other anti-diabetic medicines like sulfonylureas or insulin, as these may increase the risk of low blood sugar or other complications.

What precautions should be taken?

Before taking JUSTOZA SM 500MG Tablet, inform your doctor if you have any kidney or liver issues, heart failure, type 1 diabetes, a history of diabetic ketoacidosis, or a urinary tract infection. Regular monitoring of blood sugar levels and kidney function is advised during treatment. Avoid excessive alcohol intake as it can increase the risk of lactic acidosis. Stay well-hydrated by drinking plenty of fluids to prevent dehydration, especially if experiencing diarrhea or vomiting.

What happens if a dose is missed?

If you miss a dose of JUSTOZA SM 500MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

JUSTOZA SM 500MG Tablet should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it out of the reach of children and pets. It should generally be stored below 30°C.