Cospiaq M 25/1000mg Tab

COSPIAQ M 25/1000MG Tablet

Name: COSPIAQ M 25/1000MG Tablet Manufacturer: Torrent Pharmaceuticals Ltd.

Composition: Each tablet contains Empagliflozin 25 mg and Metformin Hydrochloride I.P. 1000 mg (as Extended Release).

Uses: COSPIAQ M 25/1000MG Tablet is primarily used for the management of Type 2 diabetes mellitus in adults. It serves as an adjunct to diet and exercise to improve glycemic control. This medicine also helps reduce cardiovascular and heart failure risks in diabetic patients, enhances insulin sensitivity, and prevents various diabetes-related complications such as kidney and nerve damage. Additionally, it may be used off-label for Polycystic Ovarian Disease (PCOS).

Dosage and Administration: Take COSPIAQ M 25/1000MG Tablet as prescribed by your physician, usually once daily, preferably with meals to minimize stomach upset. Swallow the tablet whole without chewing, crushing, or breaking it. Do not exceed the recommended dose or discontinue the medicine without consulting your doctor.

Side Effects:

• Common Side Effects: Frequent urination, mild skin rash or itchy skin, nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, metallic taste in the mouth, joint pain, and increased thirst. Women may experience vaginal yeast infections, and men may develop genital fungal infections.
• Serious Side Effects: Overdose may lead to lactic acidosis, with symptoms such as trouble breathing, unusual muscle pain, weakness, and irregular heartbeats. Seek immediate medical attention if these occur.

Precautions: COSPIAQ M 25/1000MG Tablet is contraindicated in individuals allergic to empagliflozin or metformin, those with Type 1 diabetes mellitus, severe kidney or liver disease, metabolic acidosis, or severe dehydration. It is generally not recommended during pregnancy or breastfeeding, in children under 18, or adults 85 years or older. Avoid alcohol consumption as it increases the risk of lactic acidosis and hypoglycemia. Inform your doctor about all other medications, especially diuretics, insulin, sulfonylureas, and NSAIDs, to avoid potential interactions. Ensure adequate fluid intake to prevent dehydration and maintain good hygiene to prevent genital infections.

Storage: Store in a cool and dry place, away from direct sunlight, typically between 10°C to 25°C or below 30°C. Keep out of reach of children.

COSPIAQ M 25/1000MG TAB is a combination medication containing Empagliflozin (25mg) and Metformin (1000mg), primarily used to manage Type 2 Diabetes Mellitus.

What is COSPIAQ M 25/1000MG TAB used for?

COSPIAQ M 25/1000MG TAB is used to manage Type 2 Diabetes Mellitus in adults, alongside diet and exercise. It is prescribed when diabetes is not adequately controlled by metformin alone, or metformin combined with other medicines, or for patients already taking both empagliflozin and metformin as separate medicines. Additionally, empagliflozin is indicated to reduce the risk of cardiovascular death in adults with Type 2 Diabetes Mellitus and established cardiovascular disease.

How does COSPIAQ M 25/1000MG TAB work?

COSPIAQ M combines two active ingredients:

• Empagliflozin works by inhibiting sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This blocks the reabsorption of glucose from the filtered blood back into the body, leading to increased glucose excretion in the urine and thus lowering blood sugar levels.
• Metformin works by decreasing the production of glucose in the liver, reducing glucose absorption from the intestines, and improving the body's sensitivity to insulin, which helps the body use insulin more effectively. Together, these mechanisms lead to better control of blood glucose levels.

What is the usual dosage for COSPIAQ M 25/1000MG TAB?

COSPIAQ M 25/1000MG Tablet should be taken exactly as prescribed by your doctor. It is typically taken orally once daily with a meal, preferably in the morning. The tablets should be swallowed whole and not split, crushed, dissolved, or chewed. Your doctor will determine the appropriate dose based on your condition and response to treatment. The recommended total daily dosage of empagliflozin is 10 mg, which can be increased to a maximum of 25 mg, and metformin may be increased to a maximum total daily dosage of 2,000 mg, with gradual escalation to reduce gastrointestinal side effects.

What are the possible side effects of COSPIAQ M 25/1000MG TAB?

Common side effects may include increased urination frequency, thirst, nausea, diarrhea, abdominal discomfort, and a metallic taste in the mouth. Other side effects can include urinary tract infections, bladder pain, painful or difficult urination, vaginal yeast infections in women, and genital fungal infections in men. Some individuals might experience mild skin rash or itchy skin, or low blood sugar (hypoglycemia), especially when used with other antidiabetic medicines or alcohol. Serious but rare side effects include lactic acidosis, symptoms of which can include vomiting, stomach pain, muscle cramps, general feeling of not being well, tiredness, difficulty breathing, and reduced body temperature.

Is COSPIAQ M 25/1000MG TAB safe during pregnancy or breastfeeding?

COSPIAQ M is generally not recommended during pregnancy, especially in the second and third trimesters, due to limited information on its safety and potential harmful effects on the developing baby. Similarly, it is probably unsafe to use during breastfeeding as it may be excreted into breast milk. It is crucial to consult your doctor if you are pregnant, planning to conceive, or breastfeeding to discuss the risks and benefits.

Can COSPIAQ M 25/1000MG TAB be taken with other medications?

COSPIAQ M can interact with several other medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take. Particular care should be taken if you are using:

• Diuretics (water pills like furosemide or hydrochlorothiazide) as they can increase the risk of dehydration and low blood pressure.
• Insulin and sulfonylureas (other diabetes medications like glipizide, glimepiride) as this combination can increase the risk of low blood sugar (hypoglycemia).
• NSAIDs (like ibuprofen or diclofenac) may affect kidney function, increasing the risk of metformin side effects.
• Medicines for chest pain (e.g., verapamil, ranolazine), stomach ulcers (cimetidine), HIV (dolutegravir), bacterial infections (trimethoprim), fungal infections (isavuconazole), or certain cancer treatments (crizotinib, olaparib, vandetanib) can also interact.

What precautions should be taken while taking COSPIAQ M 25/1000MG TAB?

Before taking COSPIAQ M, inform your doctor if you have kidney or liver problems, heart failure, or a history of diabetic ketoacidosis. Avoid excessive alcohol intake, as it can increase the risk of lactic acidosis. Ensure adequate hydration, especially if you experience severe vomiting, diarrhea, or reduced fluid intake. Regular monitoring of blood sugar levels is essential. This medicine is not for Type 1 Diabetes Mellitus.

What happens if a dose is missed?

If you miss a dose of COSPIAQ M, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should COSPIAQ M 25/1000MG TAB be stored?

COSPIAQ M tablets should be stored at room temperature, away from direct sunlight and moisture. Keep them out of the reach of children.