Oxramet Xr 10mg/500mg Tabs

OXRAMET XR 10MG/500MG Tablets

• Name:

  • Brand Name: OXRAMET XR 10MG/500MG
  • Common Name: Dapagliflozin and Metformin Extended-Release Tablets

• Composition:

  • Each tablet contains Dapagliflozin 10 mg and Metformin Hydrochloride (extended-release) 500 mg.

• Uses: OXRAMET XR 10MG/500MG is prescribed for adults with Type 2 Diabetes Mellitus to help control high blood sugar levels, especially when diet and exercise alone are insufficient. It also aids in reducing the risk of cardiovascular events such as heart attacks and heart failure in diabetic patients.

• Dosage and Administration: This medicine is typically taken orally once daily, preferably with a meal, to minimize stomach upset. Tablets should be swallowed whole and not crushed or chewed. It is recommended to take the dose at the same time each day to maintain consistency.

• Side Effects: Common side effects may include:

  • Sore throat, nasal congestion, runny nose
  • Headache
  • Nausea, vomiting, diarrhea
  • Urinary tract infection (UTI)
  • Genital fungal infection Serious but rare side effects include lactic acidosis.

• Precautions: OXRAMET XR is not recommended for Type 1 diabetes, severe kidney or liver disease, or diabetic ketoacidosis. Caution is advised for elderly patients due to increased sensitivity to side effects like dehydration. Alcohol consumption should be avoided as it can increase the risk of lactic acidosis and low blood sugar. Inform your doctor about other medications, especially diuretics, insulin, or NSAIDs, as interactions can occur.

• Storage: Store the medicine in a cool, dry place, away from direct sunlight, and out of reach of children. It should be stored below 30°C.

Here are some frequently asked questions about OXRAMET XR 10MG/500MG TABS:

What is OXRAMET XR 10MG/500MG TABS used for?

OXRAMET XR 10MG/500MG TABS is used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet and exercise alone are not enough. Additionally, it can reduce the risk of cardiovascular events like heart attacks and heart failure in adults with type 2 diabetes and cardiovascular disease or multiple cardiovascular risk factors. It may also help lower the risk of worsening kidney disease in patients with chronic kidney disease.

How does OXRAMET XR 10MG/500MG TABS work?

This medicine contains two active ingredients: Dapagliflozin (10 mg) and Metformin (500 mg).

• Dapagliflozin is an SGLT2 inhibitor. It works in the kidneys to block the reabsorption of glucose, causing excess sugar to be excreted through urine, thereby lowering blood sugar levels.
• Metformin is a biguanide. It reduces the amount of glucose produced by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, helping cells to utilize glucose more effectively.

Together, these ingredients work through complementary mechanisms to provide better control of blood sugar.

What is the usual dosage for OXRAMET XR 10MG/500MG TABS?

The dosage of OXRAMET XR 10MG/500MG TABS is individualized by your doctor based on your current treatment, medical condition, and response to the medication. It is typically taken once daily in the morning with food to help reduce stomach upset. The tablets should be swallowed whole and not crushed, cut, or chewed. Do not stop taking this medicine without consulting your doctor, as this can lead to increased blood sugar levels and a higher risk of complications.

What are the possible side effects of OXRAMET XR 10MG/500MG TABS?

Common side effects may include:

• Sore throat, nasal congestion, runny nose
• Headache
• Nausea, vomiting, diarrhea, stomach pain, loss of appetite
• Genital fungal infections (yeast infection)
• Urinary tract infection (UTI)
• Frequent urination (polyuria)
• Dizziness
• Taste changes
• Skin rash

Most side effects are temporary and usually resolve. However, if you experience any serious side effects or a worsening of symptoms, consult your doctor.

Is OXRAMET XR 10MG/500MG TABS safe during pregnancy or breastfeeding?

OXRAMET XR 10MG/500MG TABS is generally not recommended during pregnancy, especially during the second and third trimesters, unless clearly necessary and prescribed by your doctor. For breastfeeding mothers, it is probably unsafe as it may pass into breast milk. It is crucial to discuss with your doctor if you are pregnant, planning to conceive, or breastfeeding before taking this medicine.

Can OXRAMET XR 10MG/500MG TABS be taken with other medications?

OXRAMET XR 10MG/500MG TABS can interact with other medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

• Diuretics (water pills) like furosemide and hydrochlorothiazide can increase the risk of dehydration and low blood pressure when taken with OXRAMET XR.
• Combining with insulin or other antidiabetic medications (e.g., glipizide, sulfonylureas) may increase the risk of low blood sugar (hypoglycemia).
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen can affect kidney function and the excretion of dapagliflozin and metformin.
• Iodinated contrast agents (used in certain imaging procedures) can increase the risk of lactic acidosis when combined with metformin.
• Cationic drugs such as cimetidine may interact with metformin, affecting its absorption and elimination.

What precautions should be taken while on OXRAMET XR 10MG/500MG TABS?

Several precautions should be observed:

• Kidney and Liver Conditions: This medicine is not recommended for patients with severe kidney or liver problems. Your doctor will assess your kidney function before starting and periodically during treatment.
• Dehydration: OXRAMET XR can cause increased urination, leading to dehydration. It's important to drink plenty of fluids to stay hydrated.
• Alcohol Consumption: Avoid or strictly limit alcohol intake as it can increase the risk of lactic acidosis (a serious side effect of metformin) and may worsen hypoglycemia.
• Type 1 Diabetes and Diabetic Ketoacidosis: This medicine is not for use in patients with type 1 diabetes or diabetic ketoacidosis.
• Infections: Be aware of the risk of urinary tract infections and genital fungal infections. Maintain good hygiene to help prevent these.
• Surgery/Illness: Inform your doctor if you are undergoing surgery or experience acute illness, as this may predispose you to ketoacidosis.

What happens if a dose is missed?

If you miss a dose of OXRAMET XR 10MG/500MG TABS, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one without consulting your doctor.

How should OXRAMET XR 10MG/500MG TABS be stored?

Store the tablets in a cool, dry place, away from direct sunlight and moisture. Keep it out of reach of children and pets. It should generally be stored below 30°C.