Razel A 75

RAZEL A 75 Capsule

Name: RAZEL A 75 Capsule (Brand name)

Composition: Each RAZEL A 75 capsule contains:

• Rosuvastatin: 10 mg
• Aspirin: 75 mg

Uses: RAZEL A 75 is a combination medicine primarily used to prevent serious cardiovascular events such as heart attacks and strokes. It is also prescribed for:

• Lowering abnormally elevated cholesterol and fat levels (hyperlipidaemia or dyslipidaemia) in the body by reducing "bad" cholesterol (LDL) and triglycerides, and increasing "good" cholesterol (HDL).
• Preventing the formation of blood clots by inhibiting platelet aggregation.
• Managing angina (heart-related chest pain) by enhancing blood flow and reducing the heart's workload.

Dosage and Administration: RAZEL A 75 Capsule should be taken orally with food to avoid stomach upset. Do not chew, break, or crush the capsule. It should be taken regularly at evenly spaced intervals as prescribed by your doctor, usually once daily. Do not stop taking the medicine abruptly, as this may worsen your condition and increase the risk of future heart events.

Side Effects: Common side effects may include:

• Headache
• Nausea
• Abdominal pain or discomfort
• Constipation or Diarrhea
• Muscle pain (myalgia) or weakness
• Indigestion (dyspepsia)
• Increased bleeding tendency

Serious side effects, though less common, require immediate medical attention and may include:

• Unusual bruising or bleeding
• Severe abdominal pain
• Dark urine or signs of liver damage (e.g., yellowing of the skin or eyes)
• Rhabdomyolysis (breakdown of muscle tissues, leading to kidney damage)

Precautions:

• Allergies: Do not take RAZEL A 75 if you are allergic to rosuvastatin, aspirin, or any of its components.
• Bleeding Disorders: Inform your doctor if you have active bleeding issues (e.g., peptic ulcer, brain hemorrhage), coagulation disorders, or are at risk of internal bleeding, as Aspirin increases bleeding risk.
• Liver Disease: Use with caution in patients with liver impairment; it is not recommended in active liver disease.
• Kidney Disease: Use with caution in patients with kidney disease.
• Pregnancy and Breastfeeding: RAZEL A 75 is generally considered unsafe during pregnancy and breastfeeding. Consult your doctor for alternatives.
• Alcohol: Limit alcohol consumption, as it may worsen side effects like dizziness and increase blood pressure.
• Surgery: Inform your doctor you are taking RAZEL A 75 before any scheduled surgery (including dental procedures), as it may need to be stopped a few days prior due to increased bleeding risk.
• Drug Interactions: Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements, as interactions can occur with blood thinners, antifungal drugs, HIV medications, and antacids. Antacids should be taken at least 2 hours after RAZEL A 75.
• Children: Not recommended for use in children under 16 years.

Storage: Store in a cool and dry place, away from direct sunlight. Keep out of sight and reach of children. Store below 30°C.

Frequently Asked Questions about RAZEL A 75

What is Razel A 75 used for?

Razel A 75 Capsule is primarily used to prevent serious cardiovascular events such as heart attacks, strokes, and peripheral vascular disease. It also helps to lower abnormally elevated cholesterol and fat levels (hyperlipidaemia or dyslipidaemia) in the body. Additionally, it can be prescribed to manage angina (heart-related chest pain) and reduce the risk of cardiovascular events in high-risk individuals.

How does Razel A 75 work?

Razel A 75 is a combination medicine containing Rosuvastatin (10mg) and Aspirin (75mg). Rosuvastatin is a cholesterol-lowering agent that works by blocking liver enzymes, which in turn causes the liver to produce less cholesterol. It effectively lowers "bad" cholesterol (LDL) and triglyceride levels while increasing "good" cholesterol (HDL) levels in the blood. Aspirin is a non-steroidal anti-inflammatory drug (NSAID) with anti-platelet action. It prevents platelets from clumping together, thereby decreasing the formation of blood clots and promoting free blood flow. The combined action helps to reduce plaque buildup and blood clot formation, ultimately lowering the risk of heart attack and stroke.

What is the usual dosage of Razel A 75?

The usual dosage of Razel A 75 is one capsule once daily, taken orally with or without food, as prescribed by your doctor. It is important to swallow the capsule whole and not crush, chew, or break it. You should take it regularly at evenly spaced intervals, ideally at the same time each day, to maintain steady levels in your bloodstream. Do not adjust the dosage or discontinue the medicine without consulting your healthcare provider.

What are the possible side effects of Razel A 75?

Common side effects of Razel A 75 may include headache, stomach upset (dyspepsia/indigestion), abdominal pain, nausea, constipation, diarrhea, muscle pain (myalgia), muscle spasms, joint pain (arthralgia), back pain, dizziness, insomnia, and weakness (asthenia). More serious, though less common, side effects can include unusual bruising or bleeding, severe abdominal pain, dark urine, shortness of breath, chest pain, and signs of liver damage (e.g., yellowing of the skin or eyes). If you experience any severe or persistent side effects, or signs of liver damage or muscle injury (like unusual muscle pain, tenderness, or weakness), consult your doctor immediately.

Is Razel A 75 safe during pregnancy or breastfeeding?

Razel A 75 is considered unsafe to use during pregnancy as it can have harmful effects on the fetus. If you become pregnant while taking this medicine, discontinue it immediately and consult your doctor. It is also not recommended for use by lactating mothers as it may affect the breastfed infant. Always consult your doctor before starting this medicine if you are pregnant, planning to conceive, or breastfeeding.

Can Razel A 75 be taken with other medications?

Razel A 75 can interact with several medications. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are taking.

• NSAIDs (e.g., ibuprofen): May increase the risk of gastrointestinal bleeding.
• Anticoagulants (e.g., warfarin): May enhance their effects, leading to a higher risk of bleeding.
• Antiviral medicines (e.g., ledipasvir, saquinavir, amprenavir, darunavir): Can increase rosuvastatin levels, potentially increasing muscle-related side effects.
• Fibric acid derivatives (e.g., gemfibrozil, fenofibrate): Can increase rosuvastatin levels and the risk of muscle injury.
• Antacids (containing aluminum hydroxide): Can reduce the absorption of rosuvastatin. It's advisable to take antacids at least 2 hours after taking Razel A 75.
• Cyclosporine: Can increase the risk of side effects.
• Methotrexate: May increase the effect of methotrexate, potentially leading to side effects.
• Clopidogrel: Can increase the blood levels of Razel A 75, potentially increasing the risk of side effects.

What precautions should be taken while taking Razel A 75?

• Alcohol: Avoid or limit alcohol consumption as it may worsen side effects like dizziness, increase blood pressure, and increase the risk of liver problems.
• Liver/Kidney Disease: Use with caution if you have liver or kidney problems. Regular monitoring of liver function may be required.
• Bleeding Disorders/Surgery: Inform your doctor if you have active bleeding issues (like peptic ulcer, brain hemorrhage), coagulation disorders, or a planned surgery (including dental), as the medicine may need to be stopped a few days prior to reduce the risk of bleeding.
• Muscle Problems: Be cautious if you have a history of muscle problems (rhabdomyolysis) or experience unusual muscle pain, tenderness, or weakness, especially with fever or dark urine.
• Diabetes: Rosuvastatin may impact blood sugar control, so glucose levels should be monitored closely if you have diabetes.
• G6PD Deficiency: Use with caution as it may worsen the condition and lead to anemia.
• Peptic Ulcer: Not recommended if you have an active or history of peptic ulcers due to increased risk of stomach and intestinal bleeding.
• Driving/Operating Machinery: Avoid driving or operating machinery if you experience dizziness or drowsiness.
• Children: Not recommended for use in children under 16 years.

What happens if a dose of Razel A 75 is missed?

If you miss a dose of Razel A 75, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Razel A 75 be stored?

Razel A 75 capsules should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of sight and reach of children. The recommended storage temperature is below 30°C.