Neo Mercazole 10 Tablet ( 130 Tablet )

NEO MERCAZOLE 10 TABLET

NEO MERCAZOLE 10 TABLET is a medication manufactured by ABBOTT HEALTHCARE PVT. LTD..

• Name

  • Brand Name: Neo Mercazole 10 Tablet
  • Common Name: Carbimazole (active ingredient)

• Composition Each Neo Mercazole 10 Tablet contains 10 mg of Carbimazole as its active ingredient.

• Uses Neo Mercazole 10 Tablet is an anti-thyroid agent primarily used to treat hyperthyroidism, a condition characterized by an overactive thyroid gland that produces excessive thyroid hormones. By reducing the production of thyroid hormones, it helps to alleviate symptoms such as a rapid heart rate, anxiety, and unexplained weight loss.

  It is also prescribed for:

  • Management of Graves' disease.
  • Preparation for partial thyroidectomy (surgical removal of part of the thyroid gland).
  • Before and after radioactive iodine therapy, a treatment for hyperthyroidism and thyroid cancer.

• Dosage and Administration Neo Mercazole 10 Tablet should be taken exactly as prescribed by your doctor.

  • Swallow the tablet whole with a glass of water; do not crush or chew it.
  • It can be taken with or without food.
  • For optimal results and to aid memory, it is best to take the medicine at the same time every day.
  • The dosage and duration of treatment are determined by your doctor based on your specific condition and may vary.
  • The usual adult starting dose can range from 20 mg to 60 mg per day in divided doses, with a maintenance dose typically between 10 mg and 15 mg daily, which may be taken as a single dose.
  • For children, the usual starting dose is often three 5 mg tablets per day, in divided doses. Do not exceed the recommended dose without consulting your doctor.

• Side Effects Common side effects may include:

  • Nausea, vomiting
  • Headache, dizziness
  • Joint pain, muscle pain
  • Skin rashes, itching, and tingling sensation
  • Gastrointestinal disturbances like diarrhea or constipation
  • Hair thinning or loss

  Serious, though rare, side effects that require immediate medical attention include:

  • Severe reduction in white blood cells (agranulocytosis), which can manifest as a sore throat, mouth ulcers, fever, or general illness.
  • Liver dysfunction, indicated by symptoms such as light-colored stools, yellowing of eyes or skin (jaundice), tiredness, stomach pain, dark urine, or loss of appetite.
  • Inflammation of the pancreas (acute pancreatitis).
  • Bleeding or unexplained bruising.
  • Serious allergic reactions (skin rash, itching/swelling, severe dizziness, difficulty breathing).

• Precautions

  • Pregnancy and Breastfeeding: Use with caution during pregnancy, and effective contraceptive measures are recommended while taking this medicine. Breastfeeding is generally not recommended as carbimazole can pass into breast milk and may harm the baby.
  • Liver Disease: Inform your doctor if you have liver problems or a history of them, as this medication could worsen the condition. Avoid if you have a severe liver disorder.
  • Blood Disorders: Use with extreme caution if you have blood-related disorders, including bone marrow depression, as it can further decrease white blood cell count. Regular blood tests may be required to monitor blood cell levels.
  • Allergies: Do not take if you are allergic to carbimazole or any other anti-thyroid medicines.
  • Alcohol: There is no known interaction between Neo-Mercazole 10 Tablet and alcohol, but it is wise to discuss it with your doctor. Some sources suggest alcohol is contraindicated as it may worsen side effects.
  • Drug Interactions: Inform your doctor about all medicines, supplements, or herbal products you are taking to avoid possible interactions. Neo Mercazole can interact with drugs like theophylline, prednisolone, erythromycin, digitalis, and beta-blockers, potentially requiring dose adjustments.
  • Children: Not recommended for children below two years of age due to lack of safety and efficacy data.
  • Driving and Operating Machinery: May cause dizziness, so drive only if you are alert.

• Storage Store Neo Mercazole 10 Tablet at room temperature, ideally between 15-30°C, and below 30°C or 25°C.

  • Keep the medicine in a dry place, away from light and moisture.
  • Keep out of sight and reach of children.
  • Ensure to use the medicine before its expiry date.

NEO MERCAZOLE 10 TABLET (containing Carbimazole) is an antithyroid medication used to manage an overactive thyroid gland. Below are frequently asked questions about this medicine.

What is NEO MERCAZOLE 10 TABLET used for?

NEO MERCAZOLE 10 TABLET is primarily used to treat hyperthyroidism, a condition where the thyroid gland produces excessive thyroid hormones. It helps to control this overactivity and reduce symptoms like rapid heartbeat, weight loss, anxiety, sweating, and irritability. It may also be used to prepare patients for thyroid surgery (thyroidectomy) or radioactive iodine treatment.

How does NEO MERCAZOLE 10 TABLET work?

NEO MERCAZOLE 10 TABLET contains the active ingredient carbimazole, which is a prodrug. After absorption, it is converted into its active form, methimazole. Methimazole works by preventing the thyroid peroxidase enzyme from incorporating iodine into tyrosine residues on thyroglobulin, which is a crucial step in the synthesis of thyroid hormones (T3 and T4). By inhibiting this process, it reduces the production of thyroid hormones, thereby bringing hormone levels back to a normal range.

What is the usual dosage for NEO MERCAZOLE 10 TABLET?

The dosage of NEO MERCAZOLE 10 TABLET is individualized based on the severity of the condition and the patient's response. For adults, initial doses typically range from 20 mg to 60 mg per day, divided into two or three doses. Once thyroid hormone levels are controlled, the dose is gradually reduced to a maintenance level, usually between 5 mg and 15 mg daily. It's important to take the tablets at the same times each day, with or without food, as directed by your doctor.

What are the possible side effects of NEO MERCAZOLE 10 TABLET?

Common side effects can include stomach upset, nausea, headache, dizziness, skin rash, itching, hair thinning, and joint pain. Most of these are mild and often improve as your body adjusts to the medicine.

Serious side effects, though rare, can occur and require immediate medical attention:

• Blood disorders: NEO MERCAZOLE can rarely cause a significant drop in white blood cells (agranulocytosis), increasing the risk of infection. Symptoms include sore throat, mouth ulcers, fever, unusual tiredness, or unexplained bruising/bleeding.
• Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, loss of appetite, right upper abdominal pain, or unusual tiredness.
• Allergic reactions: Signs include sudden rash, swelling of the face, lips, tongue, or throat, and difficulty breathing. If you experience any of these serious symptoms, stop taking the medication and consult your doctor immediately.

Is NEO MERCAZOLE 10 TABLET safe during pregnancy or breastfeeding?

NEO MERCAZOLE 10 TABLET should be used with caution during pregnancy, particularly in the first trimester and at high doses, as it is suspected to cause congenital malformations. If you are pregnant, planning to become pregnant, or could become pregnant, you must use reliable contraception during treatment. Your doctor will discuss the risks and benefits and may prescribe the lowest effective dose if treatment is necessary, with close monitoring. In some cases, propylthiouracil might be considered an alternative.

NEO MERCAZOLE passes into breast milk. Therefore, it is generally recommended not to breastfeed while taking this medication due to the potential risk of neonatal hypothyroidism and agranulocytosis in the infant.

Can NEO MERCAZOLE 10 TABLET be taken with other medications?

NEO MERCAZOLE can interact with other medications. It may enhance the effects of blood-thinning medications (anticoagulants like warfarin), increasing the risk of bleeding. It can also increase the concentration of drugs like theophylline (used for asthma) and digoxin (used for heart conditions), potentially leading to toxicity. Additionally, it may reduce the effectiveness of prednisolone (a corticosteroid) and affect the clearance of antibiotics like erythromycin. Always inform your doctor or pharmacist about all other medicines, supplements, or herbal products you are taking to avoid potential interactions.

What precautions should be taken when using NEO MERCAZOLE 10 TABLET?

Before starting treatment, inform your doctor if you have any history of:

• Allergy to carbimazole or related anti-thyroid medicines.
• Serious blood disorders or bone marrow depression.
• Severe liver disorder or mild-to-moderate liver insufficiency.
• A growth of the thyroid gland downwards into the chest (intrathoracic goitre), as this can worsen obstructive symptoms.
• Acute pancreatitis after taking carbimazole or thiamazole.

Regular blood tests will be necessary to monitor your thyroid hormone levels and blood cell counts during treatment. If you are planning for radio-iodine treatment, your doctor may advise you to temporarily stop NEO MERCAZOLE.

What happens if a dose of NEO MERCAZOLE 10 TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should NEO MERCAZOLE 10 TABLET be stored?

Store NEO MERCAZOLE 10 TABLET in a cool, dry place where the temperature stays below 25°C. Keep the tablets in their original packaging, tightly closed, and out of reach of children. Do not store it in the bathroom or near a sink, and avoid leaving it in a car or on windowsills, as heat and dampness can damage the medicine.