Tolkem Sr 450 Mg Tablet (10 Tab)

TOLKEM SR 450 MG TABLET

Name:

• Brand Name: Tolkem SR 450, Tolmove-450

Composition:

• Active Ingredients: Tolperisone Hydrochloride 450 mg (sustained-release form)

Uses: Tolkem SR 450 Tablet is a centrally acting muscle relaxant prescribed for the treatment of acute musculoskeletal pain. It is also used to relieve painful muscle spasms, rigidity, tension, and stiffness in muscles (spasticity) that can arise from various conditions affecting the nervous system. These conditions may include stroke, spinal cord injury, multiple sclerosis, Parkinson's disease, cerebral palsy, and traumatic brain injury. The medicine works by relaxing muscles, reducing pain, and enhancing blood flow to the muscles, thereby improving movement.

Dosage and Administration: The usual adult dose of Tolkem SR 450 is one tablet once daily after meals. It should be swallowed whole with a glass of water and not chewed, crushed, or broken. Taking it with food or milk helps prevent an upset stomach. The exact dosage and duration will depend on the medical condition, severity of symptoms, and individual response, and should always be followed as advised by a doctor.

Side Effects: Common side effects include:

• Dizziness, sleepiness, fatigue
• Nausea, vomiting, abdominal pain, diarrhea, indigestion
• Sweating
• Weakness, muscle weakness
• Headache, dry mouth

Serious side effects, though rare, may include hypersensitivity reactions such as flushing, rash, wheezing, severe itching, difficulty breathing, swelling of the face, lips, tongue, and/or throat, difficulty swallowing, low blood pressure, or a fast heartbeat. If any severe or persistent side effects occur, medical attention should be sought immediately.

Precautions:

• Allergies: Inform your doctor if you have any known allergies to Tolperisone or any other ingredients.
• Medical Conditions: Exercise caution and inform your doctor if you have myasthenia gravis (as it may worsen muscle weakness), asthma, hay fever, or severe liver or kidney problems.
• Pregnancy and Breastfeeding: Tolkem SR 450 Tablet should be used with caution during pregnancy only if clearly advised by a doctor. It is not recommended for use in breastfeeding women.
• Alcohol: Avoid consuming alcohol as it may increase drowsiness and dizziness.
• Driving and Operating Machinery: Due to potential dizziness, sleepiness, or blurred vision, avoid driving or activities requiring concentration until you understand how the medicine affects you.
• Do not exceed the prescribed dose to avoid overdose.
• Do not stop taking the medicine suddenly without consulting a doctor, especially if used for a long time.
• The safety and efficacy in children have not been established.

Storage:

• Store below 25°C.
• Keep this medicine out of the sight and reach of children.

Tolkem SR 450 MG Tablet is a medication used as a muscle relaxant, primarily for the relief of painful muscle spasms and stiffness. The active ingredient in Tolkem SR 450 MG Tablet is Tolperisone Hydrochloride 450 mg. The "SR" in its name indicates a sustained-release formulation, which allows for a prolonged and consistent release of the medication.

What is Tolkem SR 450 MG Tablet used for?

Tolkem SR 450 MG Tablet is used to relieve painful muscle spasms of the skeletal muscles and the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, and stiffness. It is also prescribed for chronic back pain, spinal and joint pain, and muscle stiffness in various conditions affecting the nervous system. These conditions can include spasticity resulting from neurological disorders such as stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and traumatic brain injury.

How does Tolkem SR 450 MG Tablet work?

Tolkem SR 450 MG Tablet contains Tolperisone, a centrally acting muscle relaxant. It works on centers in the brain and spinal cord to relieve muscle stiffness or spasms without significantly reducing muscle strength. The precise mechanism involves blocking voltage-gated sodium and calcium channels in nerve fibers, which helps to inhibit nerve impulses that cause muscle contractions and reduce muscle hyperactivity. Additionally, it increases blood supply to the muscles, which can improve movement and reduce muscle pain.

What is the usual dosage of Tolkem SR 450 MG Tablet?

The dosage of Tolkem SR 450 MG Tablet should be exactly as prescribed by a physician. As a sustained-release (SR) tablet, it is typically administered once daily. The tablet should be swallowed whole with a glass of water and not broken, crushed, or chewed. It should be taken with or after food or a glass of milk to minimize stomach upset and improve absorption.

What are the possible side effects of Tolkem SR 450 MG Tablet?

Common side effects of Tolkem SR 450 MG Tablet may include dizziness, sleepiness, headache, muscle weakness, nausea, vomiting, abdominal pain, diarrhea, dry mouth, sweating, and weakness. Most of these side effects are temporary and usually resolve over time. However, if any side effects persist or worsen, it is advised to consult a doctor. Rarely, severe allergic reactions such as rash, itching, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or a rapid decrease in blood pressure may occur, requiring immediate medical attention.

Is Tolkem SR 450 MG Tablet safe during pregnancy or breastfeeding?

Tolkem SR 450 MG Tablet is generally not recommended for use during pregnancy, especially in the initial three months, unless explicitly advised by a doctor who has weighed the potential risks against the benefits. For breastfeeding women, Tolkem SR 450 MG Tablet is not recommended and should not be used as it may cause harm to the newborn baby. It is crucial to inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can it be taken with other medications?

No drug interactions of Tolperisone hydrochloride have been reported with the concomitant intake of benzodiazepines, non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, and alcohol in clinical trials. However, it is important to inform your doctor about all other prescription or non-prescription drugs, herbal medicines, and diet supplements you are taking to avoid potential interactions. Concurrent use with other muscle relaxants like Methocarbamol may cause visual disturbances. Taking it with painkillers such as niflumic acid or other NSAIDs may increase the effect of Tolperisone.

What precautions should be taken?

Tolkem SR 450 MG Tablet may cause dizziness or sleepiness, so it is important to avoid driving or operating heavy machinery or any activity requiring concentration until you understand how the medication affects you. Alcohol consumption should be avoided as it may cause excessive drowsiness. Inform your doctor if you have any allergies to Tolperisone or lidocaine, myasthenia gravis (a condition causing muscle weakness), asthma, hay fever, or severe liver or kidney problems, as the medicine may be contraindicated or require caution in these conditions. Do not stop taking the medicine suddenly without consulting your doctor, especially if you have been on it for a long time, as it can lead to a recurrence of symptoms.

What happens if a dose is missed?

If you miss a dose of Tolkem SR 450 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

Tolkem SR 450 MG Tablet should be stored at a temperature not exceeding 30°C. It should be protected from light and moisture. Keep this medicine out of the sight and reach of children.