Ajaduo 10mg/ 5 Mg Tablet (10 Tab)

AJADUO 10MG/5MG TABLET

AJADUO 10mg/5mg Tablet, manufactured by Lupin Ltd., is a combination medication prescribed for the management of type 2 diabetes mellitus. It works as part of a comprehensive treatment plan that includes a healthy diet and regular exercise.

• Composition AJADUO 10mg/5mg Tablet contains two active ingredients: Empagliflozin 10 mg and Linagliptin 5 mg.

  • Empagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitor that works by increasing the removal of excess glucose from the body through urine.
  • Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps control blood sugar levels by increasing the release of insulin, especially after meals, and reducing glucose production by the liver.

• Uses AJADUO 10mg/5mg Tablet is primarily used for:

  • Treating type 2 diabetes mellitus in adults to improve blood sugar control.
  • Reducing the risk of cardiovascular death and hospitalization in adults with type 2 diabetes and established cardiovascular disease or heart failure.
  • Protecting kidneys in adults with chronic kidney disease. Controlling high blood sugar helps prevent complications such as kidney damage, blindness, nerve problems, and limb loss.

• Dosage and Administration Take AJADUO 10mg/5mg Tablet orally once daily in the morning, with or without food, as directed by your doctor. The tablet should be swallowed whole; do not crush, chew, or break it. It is important to take the medicine at the same time each day for consistent blood levels. Do not discontinue the medication without consulting your doctor, as this can lead to a rise in blood sugar levels and increased risk of complications.

• Side Effects Common side effects may include:

  • Frequent urination
  • Dizziness or light-headedness
  • Urinary tract infections (UTIs)
  • Nasopharyngitis (inflammation of the nose and throat)
  • Upper respiratory tract infections
  • Female genital mycotic (yeast) infections
  • Cough, rash, itching
  • Low blood sugar levels (hypoglycemia), especially when taken with insulin or sulfonylureas.

  Serious side effects, though less common, can include dehydration, low blood pressure, and diabetic ketoacidosis (a serious buildup of acids in the blood, which can occur even with normal blood sugar). Seek medical attention if you experience severe stomach pain, signs of acute pancreatitis, or symptoms of serious urinary tract or genital infections.

• Precautions

  • AJADUO 10mg/5mg Tablet is not recommended for individuals with type 1 diabetes mellitus, diabetic ketoacidosis, or severe kidney or liver disease.
  • Use with caution in patients with a history of heart disease, existing kidney or liver problems, hypotension (low blood pressure), or pancreatitis.
  • Inform your doctor about all medicines, supplements, or herbal products you are taking to avoid potential drug interactions.
  • Concomitant use with insulin or sulfonylureas may increase the risk of hypoglycemia. Diuretics may increase the risk of dehydration and low blood pressure.
  • Avoid alcohol consumption, as it can increase the risk of hypoglycemia and ketoacidosis.
  • Limited information is available regarding use in pregnant or breastfeeding women; it is generally not recommended during pregnancy, especially in the second and third trimesters, and not advised for breastfeeding.
  • Children under 18 years of age are generally not recommended this medication, though some sources mention use for children 10 and older for type 2 diabetes under careful monitoring. Elderly patients and those with kidney problems require careful monitoring.

• Storage Store AJADUO 10mg/5mg Tablet in a cool and dry place, away from direct sunlight, heat, and moisture, typically at 10ºC to 25ºC or below 30ºC. Keep it out of sight and reach of children and pets.

What is AJADUO 10mg/5mg Tablet used for?

AJADUO 10mg/5mg Tablet is primarily used to treat Type 2 diabetes mellitus in adults to help manage high blood sugar levels. It is typically prescribed when diet and exercise alone are not sufficient. Additionally, this medicine can help reduce the risk of cardiovascular death and hospitalization in adults with heart failure or established cardiovascular disease, and may also be used in the treatment of chronic kidney disease in adults with reduced kidney function.

How does AJADUO 10mg/5mg Tablet work?

AJADUO 10mg/5mg Tablet contains two active ingredients: Empagliflozin (10mg) and Linagliptin (5mg). Empagliflozin works by blocking a protein in the kidneys called sodium-glucose co-transporter-2 (SGLT2), which increases the removal of excess glucose from the body through urine. Linagliptin works by increasing the levels of natural substances called incretins, which help regulate blood sugar by promoting insulin release (especially after meals) and decreasing sugar production in the liver.

What is the usual dosage for AJADUO 10mg/5mg Tablet?

The typical dosage is one tablet taken orally once daily in the morning, with or without food. It is important to swallow the tablet whole and not to crush, chew, or break it. Your doctor will determine the appropriate dose and duration of treatment, and you should always follow their instructions. Do not exceed the prescribed dose or stop taking the medication without consulting your doctor.

What are the possible side effects of AJADUO 10mg/5mg Tablet?

Common side effects may include urinary tract infections (UTIs), increased urination, genital fungal infections (more common in women), nasopharyngitis (inflammation of the nose and throat), cough, nausea, vomiting, constipation, dizziness, and light-headedness. Hypoglycemia (low blood sugar) can occur, especially when taken with other anti-diabetic medications or alcohol. More serious, but rare, side effects can include diabetic ketoacidosis, dehydration, and pancreatitis. If you experience persistent or concerning side effects, consult your doctor.

Is AJADUO 10mg/5mg Tablet safe during pregnancy or breastfeeding?

Pregnancy: AJADUO 10mg/5mg Tablet is generally not recommended during pregnancy, especially in the second and third trimesters. Animal studies have shown potential harm to the developing baby's kidneys. Uncontrolled diabetes during pregnancy also poses significant risks to both the mother and baby. Always consult your doctor if you are pregnant or planning to become pregnant to discuss the safest way to manage your blood sugar.

Breastfeeding: This medicine is not advised for breastfeeding women. Limited human data suggests that the drug may pass into breast milk and could potentially harm the baby's developing kidneys. It is crucial to consult your doctor to understand the potential risks and benefits or explore safer alternative medications while breastfeeding.

Can AJADUO 10mg/5mg Tablet be taken with other medications?

AJADUO 10mg/5mg Tablet can interact with certain medications. Taking it with diuretics (water pills) may increase the risk of dehydration and low blood pressure. When co-administered with insulin or insulin secretagogues (like sulfonylureas), it can increase the risk of hypoglycemia (low blood sugar levels). The antibiotic Rifampin may reduce the effectiveness of linagliptin. Always inform your doctor about all prescription, over-the-counter medications, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while on AJADUO 10mg/5mg Tablet?

Before starting this medication, inform your doctor if you have kidney or liver problems, a history of pancreatitis, or recurrent urinary tract infections. It is important to stay well-hydrated to reduce the risk of dehydration and manage increased urination. Practice good genital hygiene to help prevent fungal infections. Avoid consuming alcohol, as it can lead to fluctuations in blood sugar levels and increase the risk of hypoglycemia and ketoacidosis. Regularly monitor your blood sugar levels as advised by your doctor. If you experience dizziness or light-headedness, rise slowly from a sitting or lying position. AJADUO 10mg/5mg Tablet is not for individuals with Type 1 diabetes or diabetic ketoacidosis, or those with severe kidney disease or on dialysis.

What happens if a dose of AJADUO 10mg/5mg Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can increase the risk of side effects.

How should AJADUO 10mg/5mg Tablet be stored?

AJADUO 10mg/5mg Tablet should be stored in a cool and dry place, away from direct sunlight, moisture, and heat. Keep the medicine out of the sight and reach of children and pets. Do not use the medication past its expiration date.