Humalog Mix 25 100 Iu/ml 3 Ml Cartridge

HUMALOG MIX 25 100 IU/ML 3 ML CARTRIDGE

Humalog Mix 25 is a pre-mixed insulin formulation designed to help manage blood sugar levels in individuals with diabetes mellitus. It contains a blend of rapid-acting and intermediate-acting insulin to provide both quick and sustained glucose control.

• Name:

  • Common Name: Insulin Lispro Mix 25/75
  • Brand Name: Humalog Mix 25

• Composition: Each milliliter (mL) contains 100 units of human insulin analog (insulin lispro mix). This mix consists of 25% insulin lispro (rapid-acting) and 75% insulin lispro protamine suspension (intermediate-acting). Non-medicinal ingredients typically include protamine sulfate, m-cresol, phenol, glycerol, dibasic sodium phosphate, zinc oxide, and water for injection. Hydrochloric acid and/or sodium hydroxide may be used to adjust pH.

• Uses: Humalog Mix 25 is indicated for the treatment of patients with Type 1 and Type 2 diabetes mellitus to improve glycemic control. It helps to lower blood sugar levels after meals and reduces the risk of serious complications associated with diabetes.

• Dosage and Administration: The dosage should be individualized and adjusted by a physician based on the patient's metabolic needs, blood glucose monitoring results, and glycemic control goals. Humalog Mix 25 is typically injected subcutaneously into the upper arms, thighs, buttocks, or abdomen. Injection sites should be rotated to reduce the risk of lipodystrophy. It should be administered within 15 minutes before a meal, or, if necessary, soon after a meal. It is crucial to mix the suspension thoroughly by gently rolling the cartridge between the hands at least 10 times and inverting it 10 times until it appears uniformly cloudy or milky before each use. Do not shake vigorously.

• Side Effects: The most common side effect is hypoglycemia (low blood sugar), which can manifest as dizziness, light-headedness, sweating, shakiness, confusion, headache, blurred vision, fast heartbeat, anxiety, irritability, hunger, or mood changes. Other common side effects include:

  • Injection site reactions (redness, pain, itching, swelling)
  • Lipodystrophy (skin thickening or pits at the injection site)
  • Weight gain
  • Swelling in hands or feet (edema) Serious allergic reactions (generalized rash, shortness of breath, wheezing, low blood pressure, fast pulse, sweating) are rare but possible. Hypokalemia (low blood potassium levels) can also occur.

• Precautions:

  • Do not use Humalog Mix 25 if blood sugar is too low (hypoglycemia) or if allergic to insulin lispro or any other ingredients.
  • Never share pens or syringes with other patients, even if the needle is changed, to prevent disease transmission.
  • Patients with renal or hepatic impairment may require dosage adjustments.
  • Careful glucose monitoring is essential, especially when changing insulin regimens, during illness, or with changes in diet or exercise.
  • Concomitant use with thiazolidinediones (e.g., pioglitazone) may lead to fluid retention and heart failure.
  • Be aware that certain medications (e.g., corticosteroids, beta-blockers, alcohol) can affect insulin requirements and blood glucose levels.
  • Hypoglycemia can impair the ability to concentrate and react; advise caution when driving or operating machinery.

• Storage:

  • Unopened: Store in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Do not use if it has been frozen.
  • In-use (Opened): Store at room temperature (below 30°C or 15°C to 30°C) and discard after 28 days. Do not refrigerate cartridges or pens once opened.
  • Keep away from heat and direct sunlight.
  • Do not store with a needle attached.
  • Visually inspect before use; it should appear uniformly cloudy after mixing. Do not use if it looks lumpy, grainy, discolored, or contains solid particles.

What is Humalog Mix 25 used for?

Humalog Mix 25 100 IU/ML is an antidiabetic medicine used to treat both Type 1 and Type 2 Diabetes Mellitus. It helps improve blood sugar control by enabling the body to utilize sugar for energy and by reducing the liver's production of sugar.

How does Humalog Mix 25 work?

Humalog Mix 25 is a premixed insulin, consisting of 25% rapid-acting insulin lispro and 75% intermediate-acting insulin lispro protamine suspension. Insulin is a natural hormone that regulates glucose (sugar) metabolism. This medication works by facilitating the reuptake of glucose into muscle and fat cells and by suppressing glucose production in the liver. The insulin lispro component acts quickly (within 10-15 minutes), while the protamine suspension provides a prolonged effect, lasting up to 18-22 hours.

What is the usual dosage for Humalog Mix 25?

The dosage of Humalog Mix 25 is individualized by your doctor based on your specific metabolic needs, blood glucose monitoring results, and glycemic control goals. It is typically injected subcutaneously (under the skin) within 15 minutes before a meal, or shortly after a meal if necessary. Humalog Mix 25 is usually administered twice daily. It should not be administered intravenously or used in insulin infusion pumps. Each mL of the cartridge contains 100 units of insulin.

What are the possible side effects of Humalog Mix 25?

The most common side effect is low blood sugar (hypoglycemia), which can manifest as dizziness, light-headedness, sweating, shakiness, confusion, headache, blurred vision, fast heartbeat, anxiety, irritability, or hunger. Other common side effects include reactions at the injection site such as pain, redness, swelling, itching, rash, or changes in skin tissue (lipodystrophy). Weight gain and swelling in the hands or feet (fluid retention) may also occur. Rare but serious side effects can include severe allergic reactions (e.g., body-wide rash, difficulty breathing), low blood potassium levels (hypokalemia), and heart failure, especially when used with certain other antidiabetic medications.

Is Humalog Mix 25 safe during pregnancy or breastfeeding?

Maintaining good blood glucose control is crucial throughout pregnancy. Insulin requirements typically decrease during the first trimester and increase during the second and third trimesters. Humalog Mix 25 can be taken during breastfeeding, but adjustments to the insulin dose or diet may be necessary. The amount of insulin passing into breast milk is unlikely to cause adverse effects in the baby. Inform your doctor if you are pregnant or planning to become pregnant.

Can Humalog Mix 25 be taken with other medications?

Many medications can influence blood sugar levels and your insulin requirements. Your doctor may need to adjust your Humalog Mix 25 dose and increase the frequency of blood glucose monitoring when taken with other drugs.

• Medications that may increase insulin needs: Corticosteroids, oral contraceptives, thyroid hormones, certain diuretics, atypical antipsychotics, and some lipid-lowering drugs.
• Medications that may decrease insulin needs: Oral hypoglycemic agents, ACE inhibitors, beta-blockers, salicylates, and certain antidepressants (MAOIs). Combining Humalog Mix 25 with thiazolidinediones (TZDs), such as pioglitazone, can increase the risk of fluid retention and heart failure, particularly in individuals with existing risk factors. Do not mix Humalog Mix 25 with any other insulins or diluents in the same cartridge or syringe.

What precautions should be taken when using Humalog Mix 25?

• Never share your Humalog Mix 25 cartridge or pen with another person, even if the needle is changed, to prevent disease transmission.
• Always check the insulin label carefully before each injection.
• Rotate injection sites within the recommended areas (upper arms, thighs, buttocks, or abdomen) to prevent skin changes like lipodystrophy (thickening or pitting of the skin).
• Be aware of hypoglycemia symptoms and always carry a fast-acting source of sugar (e.g., glucose tablets, fruit juice, hard candy) to treat low blood sugar quickly.
• Your insulin needs can change due to illness, stress, changes in diet or physical activity, or kidney/liver problems.
• Do not use the insulin if it appears lumpy, grainy, unusually thick, discolored, or contains solid white particles or crystals.
• Exercise caution when driving or operating machinery, as hypoglycemia can impair your concentration and reaction time.

What happens if a dose of Humalog Mix 25 is missed?

If you miss a dose that was meant to be taken before a meal, you should administer it immediately after finishing your meal. If you realize you missed a dose several hours after your meal, it's generally recommended to take your next dose at its regularly scheduled time and monitor your blood sugar levels more frequently. For mixed insulins like Humalog Mix 25, specific guidance exists: if a breakfast dose is missed by less than 2 hours, give the usual dose; if more than 2 hours overdue, give half the usual dose at lunchtime. If an evening meal dose is missed by less than 2 hours, give the usual dose. For delays over 2 hours at the evening meal, consult your doctor or pharmacist for advice on dosage adjustments, as this may depend on your current blood glucose levels.

How should Humalog Mix 25 be stored?

Unopened Humalog Mix 25 cartridges should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze the medicine. Once a cartridge is in use (opened), it should be stored at room temperature (below 30°C or up to 86°F) and discarded after 28 days, even if some insulin remains. Do not return opened pens or cartridges to the refrigerator. Keep it away from excessive heat and direct light. Never use Humalog Mix 25 if it has been frozen. Also, do not store pens or cartridges with the needle attached, as this can lead to air bubbles and contamination.