Pramirol 1

PRAMIROL 1 Tablet

PRAMIROL 1 Tablet, manufactured by Intas Pharmaceuticals Ltd., is a medication used to manage neurological conditions.

• Name:

  • Brand Name: Pramirol 1
  • Common Name: Pramipexole

• Composition:

  • Each tablet contains 1 mg of Pramipexole. Pramipexole is an antiparkinson agent belonging to the class of dopamine agonists.

• Uses: PRAMIROL 1 Tablet is primarily prescribed for the treatment of:

  • Parkinson's Disease: It helps alleviate symptoms such as tremors, stiffness, muscle spasms, and poor muscle control by mimicking the action of dopamine in the brain.
  • Restless Legs Syndrome (RLS): It is used for moderate to severe Willis-Ekbom disease (Restless Legs Syndrome), reducing uncomfortable sensations and the irresistible urge to move the legs, particularly at night.

• Dosage and Administration:

  • Take PRAMIROL 1 Tablet with or without food, as advised by your doctor.
  • For RLS, it is often recommended to take it 2 to 3 hours before bedtime.
  • Swallow the tablet whole with water; do not chew, crush, or break it.
  • Follow the prescribed dose and duration of treatment. Do not discontinue the medicine suddenly without consulting your doctor, as this can worsen your condition.

• Side Effects:

  • Common Side Effects: Dizziness, drowsiness, nausea, fatigue, constipation, dry mouth, sleepiness, headache, muscle weakness, confusion, increased urination, muscle spasms, peripheral edema (swelling of arms or legs), and trouble sleeping.
  • Serious Side Effects: Hallucinations (seeing or hearing things that aren't real), impulse control disorders (e.g., increased gambling, binge eating, compulsive spending, increased sexual drive), orthostatic hypotension (sudden drop in blood pressure upon standing), dyskinesia (uncontrolled body movements), and sudden onset of sleep during daily activities.

• Precautions:

  • Allergy: Avoid if allergic to Pramipexole or any of its contents.
  • Medical Conditions: Use with caution if you have kidney conditions, low blood pressure, heart problems, rhabdomyolysis, dyskinesia, psychosis, or other mental health conditions.
  • Pregnancy and Breastfeeding: Consult your doctor if pregnant or breastfeeding. It is not recommended during breastfeeding as it may reduce breast milk production and can pass into breast milk.
  • Alcohol: Avoid alcohol consumption as it can increase drowsiness and dizziness.
  • Driving/Operating Machinery: May cause dizziness, drowsiness, or sudden sleep. Avoid activities requiring mental alertness, such as driving or operating heavy machinery, until you know how the medicine affects you.
  • Elderly and Children: Use with caution in elderly patients; lower doses may be required. Not recommended for children below 18 years of age.

• Storage:

  • Store PRAMIROL 1 Tablet in a cool and dry place, below 30°C.
  • Protect from direct light and moisture.
  • Keep out of reach and sight of children.

PRAMIROL 1 by INTAS PHARMACEUTICALS LTD: Frequently Asked Questions

Pramirol 1 mg Tablet, manufactured by Intas Pharmaceuticals Ltd, contains the active ingredient pramipexole. It is primarily used to manage symptoms associated with Parkinson's disease and Restless Legs Syndrome (RLS).

What is PRAMIROL 1 used for?

PRAMIROL 1 is used to treat the symptoms of primary Parkinson's disease in adults, and moderate to severe primary Restless Legs Syndrome (RLS) in adults. In Parkinson's disease, it helps manage symptoms such as tremors, stiffness, and slowed movements, improving mobility and daily functioning. For RLS, it helps relieve the uncomfortable urge to move the legs, especially at night, which can lead to improved sleep quality.

How does PRAMIROL 1 work?

PRAMIROL 1 contains pramipexole, which belongs to a class of medicines called dopamine agonists. It works by mimicking the action of dopamine, a natural chemical messenger in the brain that is essential for controlling movement and coordination. By stimulating dopamine receptors in the brain, pramipexole helps to restore the balance in neural circuits affected by dopamine deficiency, thereby reducing the symptoms of Parkinson's disease and RLS.

What is the usual dosage for PRAMIROL 1?

The dosage of PRAMIROL 1 depends on the condition being treated and is determined by your doctor. For Parkinson's disease, a typical starting dose for immediate-release tablets might be 0.125 mg three times a day, which can be gradually increased every 5 to 7 days by your doctor. The maximum dosage is usually not more than 4.5 mg per day. For Restless Legs Syndrome, the suggested starting dose for immediate-release tablets is 0.125 mg once daily, usually 2 to 3 hours before bedtime. This dose can be increased every 4 to 7 days if needed, with a typical maximum dose of 0.5 mg once daily. PRAMIROL 1 can be taken with or without food. If it upsets your stomach, taking it with food may help.

What are the possible side effects of PRAMIROL 1?

Common side effects of PRAMIROL 1 may include nausea, dizziness, drowsiness, headache, constipation, dry mouth, and trouble sleeping or unusual dreams. More serious side effects, though less common, can include sudden sleep attacks during daily activities, low blood pressure upon standing (orthostatic hypotension), hallucinations, confusion, mood swings, and compulsive behaviors (e.g., increased urges to gamble, binge eat, or engage in sexual activities). You should report any concerning side effects to your doctor immediately.

Is PRAMIROL 1 safe during pregnancy or breastfeeding?

Currently, there are no adequate studies on the effects of pramipexole on human pregnancy. Animal studies have shown that pramipexole could affect fetal development at higher doses. Therefore, it should only be used during pregnancy if the potential benefit outweighs the possible risks to the unborn baby. It is not known if pramipexole passes into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, you should discuss this with your doctor, who will advise whether you should stop breastfeeding or stop taking PRAMIROL 1.

Can PRAMIROL 1 be taken with other medications?

PRAMIROL 1 can interact with other medications, including alcohol, antihistamines, certain medications for depression, anxiety, or mental health conditions, certain sleep medications, blood pressure medications, and opioid pain medications. Antipsychotics and metoclopramide can also interact with pramipexole. It's crucial to inform your doctor about all prescription and over-the-counter medicines, vitamins, herbal products, and other supplements you are currently taking to avoid potential interactions. Do not drink alcohol while taking pramipexole, as it can increase the risk of side effects like dizziness and drowsiness.

What precautions should be taken with PRAMIROL 1?

You should not suddenly stop taking PRAMIROL 1, as this can lead to serious side effects or worsen your condition. Your doctor will likely advise a gradual reduction in dosage if the medication needs to be stopped. PRAMIROL 1 can cause sudden sleepiness or "sleep attacks" without warning, so do not drive or operate machinery until you know how this medication affects you. Be cautious when standing up from a sitting or lying position to reduce the risk of dizziness or fainting due to a sudden drop in blood pressure. Inform your doctor if you have kidney disease, heart disease, low blood pressure, or a mental health condition, as these may require special considerations.

What happens if a dose of PRAMIROL 1 is missed?

If you miss a dose of PRAMIROL 1 (immediate-release tablets) for Parkinson's disease, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss a dose for restless legs syndrome, skip the missed dose and take your next regular dose 2 to 3 hours before your next bedtime. For extended-release tablets, if you miss a dose by less than 12 hours, take it as soon as you remember; otherwise, skip it and continue your regular schedule.

How should PRAMIROL 1 be stored?

PRAMIROL 1 tablets should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F), away from heat, moisture, and direct light. Keep the medication in its closed container and out of the reach of children. Do not keep outdated medicine or medicine that is no longer needed.