ADILIP 135 TABLET

ADILIP 135 TABLET is a medication manufactured by Intas Pharmaceuticals Ltd., primarily used to manage high cholesterol and triglyceride levels.

• Name:

  • Brand Name: ADILIP 135 TABLET (also seen as ADILIP 135 Tablet DR)
  • Common Name: Fenofibric acid (the active metabolite of Choline Fenofibrate).

• Composition:

  • Active Ingredient: Choline Fenofibrate 135 mg. This is a fibrate that works by stimulating lipoprotein lipase, an enzyme that breaks down "bad" cholesterol (LDL) and triglycerides, while increasing "good" cholesterol (HDL).

• Uses: ADILIP 135 TABLET is prescribed for:

  • Hypercholesterolemia (increased cholesterol levels in the blood).
  • Hypertriglyceridemia (increased triglyceride levels in the blood).
  • Lowering elevated levels of triglycerides and "bad" cholesterol (LDL).
  • Increasing "good" cholesterol (HDL).
  • Reducing the risk of cardiovascular diseases, including heart attacks and strokes, by managing cholesterol levels.
  • It can be used in situations where statin therapy alone does not effectively control blood lipid levels, sometimes in conjunction with statins.

• Dosage and Administration:

  • The daily dose should be taken as prescribed by your doctor.
  • Dosage may vary based on individual factors such as age, severity of the condition, and response to treatment.
  • The tablet should be swallowed whole with a glass of water; do not crush, chew, or break it.
  • It can be taken with or without food, but it is recommended to take it at a fixed time daily for better results and consistency.
  • It is generally recommended to be taken once a day.

• Side Effects:

  • Common Side Effects: Nausea, vomiting, flatulence, stomach pain/abdominal pain, diarrhea, headache, back pain, and upper respiratory tract infection. These are usually temporary and resolve with discontinuation of the medicine.
  • Serious Side Effects (consult doctor immediately if experienced): Severe allergic reactions (swelling of face, lips, tongue, or throat causing difficulty in breathing), cramps or painful/tender/weak muscles (signs of muscle inflammation or breakdown), pancreatitis (inflamed pancreas, signs include stomach pain), pulmonary embolism (blood clot in the lung, signs include chest pain and breathlessness), deep vein thrombosis (blood clot in the leg, signs include pain, redness, or swelling in the leg), and signs of liver problems (unusual fatigue, loss of appetite, yellowing of eyes or skin, dark-colored urine).

• Precautions:

  • Pregnancy and Breastfeeding: Not advisable during pregnancy unless deemed necessary by a doctor. Breastfeeding is generally not recommended while taking this tablet.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of muscle problems.
  • Liver/Kidney Problems: Not recommended for patients with severe liver problems, severe kidney disorders, or gallbladder problems. Caution is advised for those with a history of liver or kidney issues; inform your doctor before use.
  • Drug Interactions: Inform your doctor about all other medications being taken to prevent potential interactions. Interactions can occur with anti-coagulants (e.g., warfarin), antidiabetic medicines (e.g., rosiglitazone, pioglitazone), other antilipemic agents (statins or fibrates), and immunosuppressants (e.g., cyclosporine).
  • Muscle Issues: Inform your doctor if you experience unexplained cramps, muscle pain, tenderness, or weakness.
  • Children: Not recommended for children below 18 years of age.

• Storage:

  • Store at room temperature, ideally below 30°C or between 10°C to 25°C.
  • Protect from light and moisture.
  • Keep out of reach and sight of children.

ADILIP 135 Tablet, containing Choline Fenofibrate (equivalent to Fenofibric acid 135 mg), is an antilipemic agent used to manage abnormal blood lipid levels. Here are some frequently asked questions about this medication:

What is ADILIP 135 Tablet used for?

ADILIP 135 Tablet is primarily used to lower high levels of "bad" cholesterol (LDL) and triglycerides in the blood, while also increasing "good" cholesterol (HDL). It is prescribed for conditions such as primary hypercholesterolemia, mixed dyslipidemia, and severe hypertriglyceridemia, often when diet and exercise alone are insufficient. This action helps reduce the risk of cardiovascular diseases like heart attacks and strokes.

How does ADILIP 135 Tablet work?

ADILIP 135 Tablet contains choline fenofibrate, which is converted to its active form, fenofibric acid, in the body. Fenofibric acid works by activating peroxisome proliferator-activated receptor alpha (PPARα). This activation leads to increased breakdown (lipolysis) and elimination of triglyceride-rich particles from the plasma, and it reduces the production of very-low-density lipoprotein (VLDL). It also increases the levels of good cholesterol (HDL).

What is the usual dosage for ADILIP 135 Tablet?

ADILIP 135 Tablet is typically taken once a day, as prescribed by your doctor. It can generally be taken with or without food. It is important to follow your doctor's instructions regarding the exact dosage and duration for optimal results and to maintain a consistent daily time for taking the medication.

What are the possible side effects of ADILIP 135 Tablet?

Common side effects may include stomach pain, nausea, vomiting, diarrhea, flatulence (gas), headache, back pain, and upper respiratory tract infection. More serious, though less common, side effects can include liver problems (e.g., elevated liver enzymes, jaundice), muscle problems (myalgia, weakness, tenderness, or rhabdomyolysis), gallstones, and pancreatitis. If you experience severe or persistent side effects, or symptoms like unexplained muscle pain, dark urine, severe abdominal pain, or yellowing of the skin/eyes, contact your doctor immediately.

Is ADILIP 135 Tablet safe during pregnancy or breastfeeding?

ADILIP 135 Tablet is generally not recommended during pregnancy as it may cause harm to the unborn baby, and its use is typically advised only if the potential benefit outweighs the risk. Similarly, its use is not recommended while breastfeeding due to concerns about potential adverse effects on the nursing infant's lipid metabolism. It is crucial to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can ADILIP 135 Tablet be taken with other medications?

ADILIP 135 Tablet can interact with several medications. It is important to inform your doctor about all other medicines you are taking, including over-the-counter drugs and supplements. Notable interactions include:

• Blood thinners (e.g., warfarin): May increase the risk of bleeding.
• Statins (e.g., simvastatin, atorvastatin): Concomitant use may increase the risk of muscle problems (myopathy or rhabdomyolysis).
• Other fibrates (e.g., gemfibrozil): Increased risk of muscle damage.
• Antidiabetic medicines (e.g., rosiglitazone, pioglitazone): May lead to bone loss or affect efficacy.
• Immunosuppressants (e.g., ciclosporin): May increase the risk of kidney dysfunction.
• Bile acid sequestrants (e.g., cholestyramine): These can bind to fenofibrate, reducing its absorption. ADILIP 135 Tablet should be taken at least 1 hour before or 4-6 hours after taking a bile acid sequestrant.

What precautions should be taken while using ADILIP 135 Tablet?

Several precautions are advised when taking ADILIP 135 Tablet:

• Liver and Kidney Disease: It is contraindicated in patients with severe liver or kidney impairment, active liver disease, or pre-existing gallbladder disease. Your doctor will monitor your liver and kidney function regularly.
• Muscle Pain: Report any unexplained muscle pain, tenderness, weakness, or cramps, especially if accompanied by fever, as these could be signs of a serious muscle condition.
• Alcohol Consumption: Avoid alcohol, as it may increase the risk of muscle problems.
• Diet and Exercise: This medication is part of a comprehensive treatment plan that should include a low-fat diet and regular exercise.
• Children: ADILIP 135 Tablet is not recommended for children under 18 years of age.

What happens if a dose of ADILIP 135 Tablet is missed?

If you miss a dose of ADILIP 135 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ADILIP 135 Tablet be stored?

ADILIP 135 Tablet should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F), away from excess heat, moisture, and direct sunlight. Keep the medication in its original container, tightly closed, and out of reach of children.