Exduo 100 Tab

EXDUO 100 TAB

Name

• Brand Name: EXDUO 100 TAB
• Common Name: Sacubitril/Valsartan

Composition EXDUO 100 TAB contains a combination of two active ingredients: Sacubitril (49mg) and Valsartan (51mg). Sacubitril is a neprilysin inhibitor, while Valsartan is an angiotensin receptor blocker (ARB).

Uses EXDUO 100 TAB is primarily used for the treatment of chronic heart failure in adults and children above one year of age. It helps to reduce the risk of hospitalization and death in individuals with heart failure by improving the heart's ability to pump blood efficiently. This medication works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body. It also aids in reducing fluid retention, alleviating symptoms such as shortness of breath, fatigue, and swelling in the feet and ankles.

Dosage and Administration EXDUO 100 TAB should be taken exactly as prescribed by a physician. It is typically administered orally, once or twice daily, with or without food. Tablets should be swallowed whole and not crushed, chewed, or broken. Taking the medicine at the same time each day is recommended for maximum benefit. Do not exceed the recommended dose.

Side Effects Common side effects may include:

• Low blood pressure (hypotension), which can cause dizziness, lightheadedness, or fainting
• Increased potassium levels in the blood (hyperkalemia)
• Cough
• Dizziness and fatigue
• Nausea, diarrhea, vomiting, and abdominal discomfort
• Headache

Serious side effects, though less common, can include allergic reactions (rash, itching, swelling of the face, lips, tongue, or throat – angioedema), liver problems, and significant kidney problems. Seek immediate medical attention if any severe or persistent side effects occur.

Precautions

• Inform your doctor about any allergies to Sacubitril, Valsartan, or other ingredients.
• Do not take EXDUO 100 TAB with ACE inhibitors (e.g., captopril, enalapril) and allow at least 36 hours between stopping an ACE inhibitor and starting EXDUO 100 TAB, or vice versa, due to an increased risk of angioedema.
• Caution is advised in patients with kidney or liver diseases; dose adjustment may be necessary, and regular monitoring of kidney function is recommended.
• Not recommended during pregnancy as it can harm the unborn baby, and it is generally advised to avoid during breastfeeding.
• Avoid taking potassium supplements or potassium-rich foods, as this medicine can increase potassium levels.
• Limit alcohol consumption as it may intensify side effects like dizziness.
• May cause dizziness; avoid driving or operating heavy machinery if affected.
• Inform your doctor about all other medications, supplements, and herbal products being taken to avoid potential drug interactions.

Storage Store EXDUO 100 TAB in a cool, dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children. The ideal storage temperature is between 10ºC to 25ºC or below 30ºC. Always check the expiry date before use.

What is EXDUO 100 TAB used for?

EXDUO 100 TAB is primarily used in adults for the treatment of chronic heart failure, a condition where the heart cannot pump blood as effectively as it should. It helps to reduce the risk of death and hospitalization in patients with this condition. This medication can also help alleviate associated symptoms such as shortness of breath, fatigue, and swelling in the feet and ankles.

How does EXDUO 100 TAB work?

EXDUO 100 TAB is a combination medicine containing Sacubitril (49mg) and Valsartan (51mg). Sacubitril works by inhibiting an enzyme called neprilysin, which helps increase the levels of beneficial peptides that relax blood vessels, increase sodium and water excretion, and reduce strain on the heart. Valsartan is an angiotensin II receptor blocker (ARB) that blocks the effects of angiotensin II, a hormone that causes blood vessels to narrow. By blocking this, Valsartan helps relax and widen blood vessels, making it easier for the heart to pump blood and lowering blood pressure.

What is the usual dosage for EXDUO 100 TAB?

The dosage of EXDUO 100 TAB is determined by your doctor based on your specific medical condition and response to the medicine. It can be taken with or without food, but it is recommended to take it at the same time each day to maintain consistent effectiveness. The tablet should be swallowed whole with a glass of water; do not chew, crush, or break it unless specifically instructed by your healthcare provider.

What are the possible side effects of EXDUO 100 TAB?

Common side effects may include cough, dizziness, nausea, diarrhea, weakness, headache, fainting, low blood pressure (hypotension), and high potassium levels in the blood (hyperkalemia). Some individuals might also experience stomach pain or kidney problems. In rare cases, more serious side effects like angioedema (swelling of the face, lips, tongue, or throat) can occur, requiring immediate medical attention.

Is EXDUO 100 TAB safe during pregnancy or breastfeeding?

EXDUO 100 TAB is generally not recommended during pregnancy, especially after the first three months, as it can potentially harm the unborn baby. Your doctor will assess the risks and benefits if you are pregnant or planning to become pregnant. It is also not recommended for use by breastfeeding mothers. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can EXDUO 100 TAB be taken with other medications?

It is crucial to inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential drug interactions. EXDUO 100 TAB should not be taken with ACE inhibitors (e.g., enalapril, captopril), and there should be a gap of at least 36 hours before or after taking an ACE inhibitor. Concomitant use with aliskiren is also not recommended, particularly in patients with diabetes or kidney disease. Caution is advised when taking it with potassium-sparing diuretics, potassium supplements, NSAIDs (painkillers), or lithium, as these can increase the risk of side effects like high potassium levels or kidney issues.

What precautions should be taken while taking EXDUO 100 TAB?

Before taking EXDUO 100 TAB, inform your doctor if you have any allergies to sacubitril, valsartan, or any other ingredients. Also, disclose if you have kidney or liver diseases, a history of hereditary angioedema, or diabetes. Since this medication can cause dizziness or tiredness, avoid driving or operating heavy machinery until you know how it affects you. To prevent dizziness from low blood pressure, get up slowly and carefully from a sitting or lying position. It's advisable to limit or avoid alcohol consumption as it may intensify certain side effects. Your doctor may recommend regular monitoring of your blood pressure and kidney function. Maintaining a low-sodium diet and avoiding potassium-rich foods or potassium supplements is also often advised.

What happens if a dose of EXDUO 100 TAB is missed?

If you miss a dose of EXDUO 100 TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should EXDUO 100 TAB be stored?

EXDUO 100 TAB should be stored in a cool, dry place, away from direct sunlight and moisture. Keep the medication out of the sight and reach of children. Ideally, it should be stored at room temperature, below 30°C. Always check the expiry date before use.