Deriphyllin Od 450

DERIPHYLLIN OD 450 by ZYDUS CADILA

Name

• Brand Name: DERIPHYLLIN OD 450MG TABLET (also known as DERIPHYLLIN OD 450 Tablet PR)
• Manufacturer: Zydus Cadila

Composition DERIPHYLLIN OD 450 contains a combination of two bronchodilators:

• Etophylline: 346 mg
• Theophylline: 104 mg

Uses This medication is primarily used as a bronchodilator to manage and alleviate symptoms of various respiratory conditions by relaxing muscles and widening the airways of the lungs, making breathing easier. It is prescribed for:

• Asthma
• Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and emphysema
• Other lung diseases causing bronchospasms
• Neonatal Apnea

Dosage and Administration DERIPHYLLIN OD 450 should be taken orally as prescribed by a doctor. It is usually taken after food, though some sources suggest it can be taken with or without food every 6 to 8 hours. It's advised to swallow the tablet whole without chewing, crushing, or breaking it. For best results and to reduce gastrointestinal discomfort, some recommend taking it with meals. Do not exceed the prescribed dosage.

Side Effects Common side effects may include:

• Nausea, vomiting, stomach discomfort and pain, diarrhea
• Headache, dizziness, restlessness, irritability, insomnia (sleeplessness)
• Increased/irregular heart rate, palpitations, tachycardia
• Tremors, twitching and unusual muscle movement

Serious side effects can include convulsions, allergic skin reactions, yellow colored eyes or skin, and elevated liver enzymes. High doses may lead to severe seizures or be fatal.

Precautions

• Pregnancy and Breastfeeding: Caution is advised, and usage should only be if prescribed by a doctor after discussing risks and benefits. It may be unsafe during pregnancy and breastfeeding.
• Contraindications: Avoid if allergic to etophylline or theophylline. Contraindicated in individuals with a heart rhythm disorder, history of heart attack, active peptic ulcer disease, severe liver or kidney disease, or seizure disorders.
• Interactions: Inform your doctor about all other medications, including prescribed, non-prescribed, and herbal drugs, as some may interact. Smoking can interfere with drug absorption. Limit or avoid alcohol consumption.
• Monitoring: Regular monitoring of potassium levels is recommended as it may cause low potassium levels.
• This medication is not for immediate relief of acute asthma attacks; a fast-acting inhaler should be kept for such situations.

Storage Store in a cool, dry place, away from sunlight and moisture. Keep the medicine out of sight and reach of children and pets. Store at room temperature (20-25°C) or below 30°C.

Here are the most frequently asked questions about DERIPHYLLIN OD 450 by ZYDUS CADILA, along with concise, accurate answers:

1. What is DERIPHYLLIN OD 450 used for?

DERIPHYLLIN OD 450 is a bronchodilator primarily used to prevent and treat symptoms associated with asthma and Chronic Obstructive Pulmonary Disease (COPD), including chronic bronchitis and emphysema. It helps to alleviate symptoms such as coughing, wheezing, shortness of breath, and chest tightness by opening up the airways.

2. How does DERIPHYLLIN OD 450 work?

DERIPHYLLIN OD 450 contains two active ingredients: Theophylline and Etofylline. Both are bronchodilators that work by relaxing the smooth muscles in the airways and widening them, which makes breathing easier. They also help to prevent mucus buildup and reduce the airways' sensitivity to irritants.

3. What is the usual dosage and how should I take it?

The dosage of DERIPHYLLIN OD 450 is determined by your doctor based on your medical condition, age, body weight, and response to treatment. You should swallow the tablet whole with a glass of water, without chewing, crushing, or breaking it, as this may disrupt its extended-release mechanism. It is often recommended to take it after food. Do not exceed the prescribed dosage.

4. What are the possible side effects of DERIPHYLLIN OD 450?

Common side effects may include nausea, vomiting, headache, restlessness, dizziness, irregular heartbeat (palpitations/tachycardia), stomach upset, diarrhea, and sleeplessness (insomnia). Other possible side effects can include tremors, low potassium levels (hypokalaemia), high blood sugar levels (hyperglycaemia), rash, increased urination, and in rare cases, convulsions. Most side effects are temporary; however, if they persist or worsen, consult your doctor.

5. Is DERIPHYLLIN OD 450 safe during pregnancy or breastfeeding?

DERIPHYLLIN OD 450 is generally not recommended during pregnancy unless absolutely necessary, and only if the potential benefits outweigh the risks. It is advised to consult your doctor if you are pregnant, planning pregnancy, or breastfeeding. The components of this medicine can pass into breast milk, and it is generally considered probably unsafe during breastfeeding, though some sources suggest that avoiding breastfeeding for 2-4 hours after a dose may reduce infant exposure.

6. Can DERIPHYLLIN OD 450 be taken with other medications or substances?

DERIPHYLLIN OD 450 can interact with various medications and substances. Inform your doctor about all medicines, supplements, and herbal products you are currently taking. It is advisable to limit or avoid alcohol and excessive caffeine consumption (e.g., from coffee, tea, chocolate) as they can increase the risk of side effects. This medicine may also interact with certain drugs like barbiturates, carbamazepine, rifampin, phenytoin, beta-blockers, diuretics, and some anti-infectives.

7. What precautions should be taken while using DERIPHYLLIN OD 450?

Inform your doctor if you have a history of heart rhythm disorders, peptic ulcers, liver or kidney disease, seizure disorders, or hyperthyroidism, as DERIPHYLLIN OD 450 should be used with caution in these conditions. Regular monitoring of potassium levels may be recommended. Avoid smoking, as it can affect the medicine's effectiveness and worsen your condition. Do not drive or operate machinery if you experience dizziness.

8. What happens if a dose of DERIPHYLLIN OD 450 is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

9. How should DERIPHYLLIN OD 450 be stored?

DERIPHYLLIN OD 450 should be stored in a cool and dry place, away from direct sunlight, heat, and moisture. Keep it in its original packaging and ensure it is out of the sight and reach of children and pets.