Glucreta Lm 500 Tab

GLUCRETA LM 500 Tablet

GLUCRETA LM 500 Tablet is a prescription medicine manufactured by Torrent Pharmaceuticals Ltd., used for the management of type 2 diabetes mellitus. It is a triple-combination medication designed to help control elevated blood sugar levels when diet and exercise alone are insufficient.

• Composition GLUCRETA LM 500 Tablet contains three active ingredients:

  • Dapagliflozin (10 mg)
  • Linagliptin (5 mg)
  • Metformin Hydrochloride (500 mg)

• Uses GLUCRETA LM 500 Tablet is primarily used for the management of type 2 diabetes mellitus in adults. It works by improving insulin sensitivity, reducing the amount of glucose produced by the liver, increasing insulin release, and promoting the excretion of excess glucose through urine. This comprehensive approach helps to lower high blood sugar levels, improve overall glycemic control, and reduce the risk of diabetes-related complications.

• Dosage and Administration Take GLUCRETA LM 500 Tablet exactly as prescribed by your doctor. It is typically taken once or twice daily, swallowed whole with a full glass of water, either with or after meals to minimize stomach discomfort. Do not crush, break, or chew the tablet. For optimal control, it is recommended to take the medicine at the same time each day. Never adjust your dose without consulting your doctor, and do not double a dose to make up for a missed one.

• Side Effects Common side effects include:

  • Nausea, vomiting, diarrhea, abdominal pain
  • Urinary tract infections (UTIs), genital fungal infections
  • Headache, dizziness, weakness
  • Metallic taste, loss of appetite, nasopharyngitis

  Serious but less common side effects may include:

  • Lactic acidosis (symptoms: rapid breathing, stomach pain, muscle cramps)
  • Hypoglycemia (low blood sugar: dizziness, sweating, confusion, shakiness)
  • Allergic reactions (rash, itching, swelling, difficulty breathing)
  • Liver or kidney problems
  • Decreased Vitamin B12 absorption

• Precautions

  • Allergies: Do not take if you are allergic to dapagliflozin, linagliptin, metformin, or any other components of the tablet.
  • Kidney/Liver Disease: Use with caution if you have kidney or liver problems; it is contraindicated in severe cases.
  • Pregnancy & Breastfeeding: Consult your doctor, as safety during pregnancy and breastfeeding is not well established.
  • Alcohol: Avoid alcohol consumption as it increases the risk of lactic acidosis.
  • Other Conditions: Inform your doctor if you have a history of heart failure, metabolic acidosis, pancreatitis, urinary tract infections, or diabetic ketoacidosis.
  • Drug Interactions: Be aware of potential interactions with diuretics, beta-blockers, corticosteroids, and insulin. Always inform your doctor about all medications, supplements, and herbal remedies you are taking.
  • Vitamin B12: Long-term use may reduce Vitamin B12 levels; annual screening may be recommended.
  • Driving: While usually safe, blood sugar fluctuations can affect your ability to drive or operate machinery.

• Storage Store GLUCRETA LM 500 Tablet at room temperature, in a cool, dry place, away from direct sunlight and moisture. Keep it out of the reach of children.

What is GLUCRETA LM 500 Tablet used for?

GLUCRETA LM 500 Tablet is an anti-diabetic combination medication used to manage type 2 diabetes mellitus (non-insulin-dependent diabetes) in adults. It is prescribed along with a proper diet and exercise regimen to help lower high blood sugar levels. This medicine helps improve insulin sensitivity, reduces glucose production, and increases glucose excretion from the body.

How does GLUCRETA LM 500 Tablet work?

GLUCRETA LM 500 Tablet contains three active ingredients: Dapagliflozin (10mg), Linagliptin (5mg), and Metformin (500mg).

• Dapagliflozin works by blocking a protein in your kidneys called sodium-glucose cotransporter 2 (SGLT2). This causes your kidneys to remove more excess glucose from your body through urine, lowering blood sugar levels.
• Linagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). By doing so, it increases the levels of incretin hormones, which stimulate the pancreas to release more insulin when blood sugar is high and reduce the amount of glucose produced by the liver.
• Metformin (a biguanide) reduces the amount of glucose your liver produces, decreases glucose absorption from the intestines after eating, and improves how your body responds to insulin.

Together, these three components provide a comprehensive approach to controlling blood sugar levels.

What is the usual dosage of GLUCRETA LM 500 Tablet?

The dosage of GLUCRETA LM 500 Tablet is determined by your doctor based on your individual needs, blood glucose levels, and response to treatment. It is typically taken orally, once or twice daily, with or after meals to minimize stomach upset. It's crucial to follow your doctor's instructions precisely and take the medicine at the same time each day for optimal blood sugar control. Do not adjust the dosage without consulting your healthcare provider.

What are the possible side effects of GLUCRETA LM 500 Tablet?

Common side effects of GLUCRETA LM 500 Tablet may include:

• Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.
• Metallic taste.
• Low blood sugar (hypoglycemia), especially if taken with other diabetes medications like insulin or sulfonylureas.
• Urinary tract infections (UTIs) and genital fungal infections.
• Headache and dizziness.
• Weakness.

Less common but potentially serious side effects include lactic acidosis (symptoms include rapid breathing, stomach pain, and muscle cramps), allergic reactions, liver problems (jaundice, dark urine), and kidney problems. Contact your doctor immediately if you experience any serious or persistent side effects.

Is GLUCRETA LM 500 Tablet safe during pregnancy or breastfeeding?

Limited information is available regarding the use of GLUCRETA LM 500 Tablet during pregnancy. It is generally not recommended during pregnancy, especially in the second and third trimesters. If you are pregnant or become pregnant while taking this medicine, inform your doctor immediately.

For breastfeeding mothers, GLUCRETA LM 500 Tablet is generally not recommended as it may pass into breast milk. It is advisable to consult your doctor before taking this medicine if you are breastfeeding.

Can GLUCRETA LM 500 Tablet be taken with other medications?

GLUCRETA LM 500 Tablet can interact with various medications. It is important to inform your doctor about all current medications, supplements, or herbal products you are taking to avoid possible interactions.

• Diuretics (e.g., furosemide, hydrochlorothiazide) can increase the risk of dehydration and low blood pressure due to the dapagliflozin component. They may also increase the risk of lactic acidosis.
• Other diabetes medications such as insulin or sulfonylureas may require dosage adjustments to avoid extremely low blood sugar levels (hypoglycemia).
• Corticosteroids (e.g., prednisolone, dexamethasone) can increase blood glucose levels, potentially reducing the effectiveness of GLUCRETA LM.
• Alcohol should be avoided as it increases the risk of lactic acidosis, a rare but serious condition, especially with the metformin component.

What precautions should be taken?

• Inform your doctor if you have severe kidney or liver disease, heart failure, a history of pancreatitis, urinary tract infections, or diabetic ketoacidosis.
• Avoid alcohol consumption while taking this medicine.
• Maintain adequate fluid intake to prevent dehydration.
• Regular monitoring of blood sugar levels is crucial.
• Be aware of the symptoms of low blood sugar (hypoglycemia) such as dizziness, sweating, and confusion, and carry a source of fast-acting glucose (like glucose tablets or juice) to treat it promptly.
• GLUCRETA LM is for adults with type 2 diabetes and is not recommended for type 1 diabetes.

What happens if a dose is missed?

If you miss a dose of GLUCRETA LM 500 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

GLUCRETA LM 500 Tablet should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children.