Nuzide M Tablet (10 Tab)

NUZIDE M TABLET (10 TAB) by INTAS PHARMACEUTICALS LTD.

Nuzide M Tablet is an oral anti-diabetic medication manufactured by Intas Pharmaceuticals Ltd., primarily used in the management of Type 2 Diabetes Mellitus.

• Name: Nuzide M Tablet

• Composition: Each tablet contains a combination of Gliclazide (80 mg) and Metformin (500 mg).

• Uses: Nuzide M Tablet is prescribed for adults with Type 2 Diabetes Mellitus when blood glucose levels are not adequately controlled by diet, exercise, and weight loss alone. It works by stimulating the pancreas to release more insulin and by reducing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. This helps to regulate blood sugar levels, thereby reducing the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart attack, and stroke.

• Dosage and Administration: Nuzide M Tablet is typically taken once or twice daily, preferably with meals, or as directed by a healthcare professional. The exact dosage (ranging from 80 mg to 320 mg daily) will be determined by the doctor based on the individual's condition and response to treatment. If a dose exceeds 160 mg, it is usually divided into two equal parts. Tablets should be swallowed whole with water and not chewed, crushed, or broken. To ensure optimal benefit, it is important to take the medicine at the same time each day and not to discontinue or alter the dose without consulting a doctor. Missed doses should not be compensated by taking a double dose.

• Side Effects:

  • Common Side Effects: Hypoglycemia (low blood sugar, characterized by dizziness, sweating, headache, shaking), nausea, vomiting, diarrhea, stomach pain/cramps, constipation, weakness, metallic taste in the mouth, skin rash, and upper respiratory tract infections.
  • Serious/Rare Side Effects: Lactic acidosis (a rare but serious condition with symptoms like muscle pain, difficulty breathing, and unusual fatigue), seizures, chest pain, severe skin reactions, unconsciousness, and vitamin B12 deficiency with long-term use.

• Precautions: Nuzide M Tablet is contraindicated in individuals with a known allergy to its ingredients, Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe kidney or liver disease, heart failure, chronic obstructive pulmonary disease, pregnancy, or breastfeeding. Alcohol consumption should be avoided as it increases the risk of hypoglycemia and lactic acidosis. Regular monitoring of blood sugar levels and kidney function tests are crucial during treatment. Patients should inform their doctor about all other medications they are taking to avoid potential drug interactions. The medication may also lower thyroid-stimulating hormone (TSH) and vitamin B12 levels. Caution is advised when driving or operating machinery due to the risk of hypoglycemia. A high-fibre diet might reduce the absorption and effectiveness of metformin.

• Storage: Store Nuzide M Tablet in a cool and dry place, protected from direct sunlight, typically below 25°C or 30°C. Keep it out of the reach and sight of children.

What is NUZIDE M TABLET used for?

NUZIDE M TABLET is used to manage Type 2 Diabetes Mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by diet, exercise, and weight loss alone. This medication helps in controlling high blood sugar levels and reduces the risk of long-term diabetes-related complications such as kidney damage, blindness, nerve problems, heart attack, and stroke.

How does NUZIDE M TABLET work?

NUZIDE M TABLET is a combination of two anti-diabetic medications: Gliclazide and Metformin. Gliclazide works by stimulating the pancreas to release more insulin, a hormone that lowers blood sugar levels. Metformin works by decreasing the production of glucose in the liver, delaying the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin. Together, these two components help to keep blood sugar levels under control.

What is the usual dosage for NUZIDE M TABLET?

NUZIDE M TABLET is typically taken once or twice daily with meals, or as prescribed by your doctor. It should be swallowed whole with a glass of water and not chewed or crushed. Taking it with food helps to minimize gastrointestinal discomfort. Your doctor will determine the appropriate dose and duration of treatment based on your individual medical condition and blood sugar levels. It is important to take the medicine at the same time each day for the best results.

What are the possible side effects of NUZIDE M TABLET?

Common side effects include low blood sugar (hypoglycemia), which can manifest as dizziness, sweating, hunger pangs, and a fast heartbeat. Other common side effects may include stomach upset, nausea, vomiting, diarrhea, constipation, headache, and a metallic taste in the mouth.

In rare cases, a serious condition called lactic acidosis may occur, characterized by symptoms like muscle pain, difficulty breathing, unusual fatigue, and stomach pain. Long-term use may also lead to a vitamin B12 deficiency. If you experience any persistent or severe side effects, you should consult your doctor.

Is NUZIDE M TABLET safe during pregnancy or breastfeeding?

No, NUZIDE M TABLET is generally not recommended during pregnancy as it may cause harm to the unborn baby. Insulin is usually preferred for controlling blood sugar levels in pregnant women with diabetes. Similarly, it is contraindicated during breastfeeding because the medicine or its metabolites may pass into breast milk and could adversely affect the nursing infant. Always consult your doctor for safer alternatives if you are pregnant, planning to conceive, or breastfeeding.

Can NUZIDE M TABLET be taken with other medications?

It is crucial to inform your doctor about all other medications you are taking, including prescribed, over-the-counter, herbal medicines, and dietary supplements, as NUZIDE M TABLET can interact with them. For example, taking it with other anti-diabetic agents like insulin can increase the risk of extremely low blood sugar levels. Interactions can also occur with diuretics, corticosteroids, ACE inhibitors, beta-blockers, and certain antifungals, among others.

What precautions should be taken while on NUZIDE M TABLET?

Do not stop taking NUZIDE M TABLET without consulting your doctor, even if you feel well, as this can cause blood sugar levels to rise. Regularly monitor your blood sugar levels and carry a quick source of sugar (like glucose tablets or fruit juice) to manage potential low blood sugar episodes. Avoid alcohol consumption, as it can increase the risk of hypoglycemia and lactic acidosis. Inform your doctor if you have any history of heart, liver, or kidney diseases, as severe cases may contraindicate its use. Regular monitoring of kidney function, TSH (thyroid-stimulating hormone), and Vitamin B12 levels may be advised.

What happens if a dose of NUZIDE M TABLET is missed?

If you miss a dose of NUZIDE M TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can lead to a drastic fall in blood glucose levels. Missing a dose may result in high blood sugar levels.

How should NUZIDE M TABLET be stored?

NUZIDE M TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. The typical storage temperature is below 25°C or 30°C. Keep the medicine out of sight and reach of children.