Sitabless Mxr 100/1000mg Tab

SITABLESS MXR 100/1000MG TAB by MANKIND PHARMA LTD.

Name

• Brand Name: SITABLESS MXR 100/1000MG TAB
• Common Name (Active Ingredients): Sitagliptin and Metformin

Composition SITABLESS MXR 100/1000MG TAB contains two active ingredients:

• Sitagliptin: 100 mg
• Metformin: 1000 mg

Uses This medication is primarily used to manage Type 2 Diabetes Mellitus in adults. It is prescribed to improve blood sugar control, especially in patients whose blood sugar levels are not adequately managed by Metformin alone. By helping to control blood glucose, it can reduce the risk of serious diabetes-related complications such as kidney damage, blindness, nerve problems, heart-related issues, and sexual dysfunction.

Dosage and Administration SITABLESS MXR 100/1000MG TAB is typically an extended-release tablet and should be taken once daily with a meal, preferably in the evening. The tablet should be swallowed whole and not split, crushed, or chewed. The specific dosage and frequency will be determined by a doctor based on the patient's condition and existing medications.

Side Effects

• Common Side Effects: Diarrhea, nausea, vomiting, abdominal pain, headache, upper respiratory tract infection, and low blood sugar levels (hypoglycemia). Some patients may also experience flatulence.
• Serious Side Effects: Rare but serious side effects include lactic acidosis (a medical emergency, especially in patients with kidney problems), pancreatitis, severe allergic reactions (e.g., anaphylaxis, angioedema), and serious skin conditions like Stevens-Johnson syndrome or bullous pemphigoid. Severe joint pain has also been reported.

Precautions

• SITABLESS MXR 100/1000MG TAB is contraindicated in patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2), acute metabolic acidosis (including lactic acidosis or diabetic ketoacidosis), and hepatic impairment.
• Caution is advised in patients with heart failure, severe infection, shock, or dehydration.
• Alcohol consumption should be avoided as it can increase the risk of lactic acidosis and severe low blood sugar.
• Renal function should be assessed before starting treatment and regularly thereafter.
• Long-term use of Metformin may lead to Vitamin B12 deficiency.
• The risk of hypoglycemia increases if taken with insulin or sulfonylureas, and dosage adjustments of these medications may be necessary.
• Not recommended during pregnancy or breastfeeding. It should not be used for Type 1 diabetes.

Storage Store the medicine below 30°C (86°F). Keep it out of the sight and reach of children.

SITABLESS MXR 100/1000MG TAB, manufactured by Mankind Pharma Ltd., is a combination medication containing Sitagliptin (100mg) and Metformin (1000mg). It is primarily used to manage type 2 diabetes mellitus by helping to control high blood sugar levels.

Here are some frequently asked questions about SITABLESS MXR 100/1000MG TAB:

What is SITABLESS MXR 100/1000MG TAB used for?

SITABLESS MXR 100/1000MG TAB is used, along with a proper diet and exercise program, to treat high blood sugar levels in adults with type 2 diabetes mellitus. It helps improve blood glucose control, especially when blood sugar is not adequately managed by Metformin alone or as part of combination therapy.

How does SITABLESS MXR 100/1000MG TAB work?

This medicine combines two active ingredients, Sitagliptin and Metformin, which work through different but complementary mechanisms. Sitagliptin is a DPP-4 inhibitor that increases the levels of natural substances called incretins (GLP-1 and GIP). These incretins help the pancreas release more insulin (especially after meals) and reduce the amount of sugar produced by the liver. Metformin, a biguanide, works by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and improving the body's sensitivity to insulin.

What is the usual dosage for SITABLESS MXR 100/1000MG TAB?

The dosage of SITABLESS MXR 100/1000MG TAB is individualized by your doctor based on your current antidiabetic regimen, effectiveness, and tolerability. It is typically taken twice daily with meals to help reduce stomach upset. The maximum recommended daily dosage is usually not more than 100 mg of sitagliptin and 2000 mg of metformin.

What are the possible side effects of SITABLESS MXR 100/1000MG TAB?

Common side effects can include nausea, vomiting, stomach upset, diarrhea, headache, weakness, a metallic taste in the mouth, upper respiratory tract infection, stuffy or runny nose, and sore throat.

Serious, but rare, side effects may include lactic acidosis (a build-up of lactic acid in the blood, especially with kidney problems, excessive alcohol use, or dehydration), pancreatitis (inflammation of the pancreas), severe joint pain, serious allergic reactions (e.g., rash, swelling of face/lips/tongue/throat), kidney problems, and bullous pemphigoid (large, hard skin blisters). Long-term use may also lead to Vitamin B12 deficiency.

Is SITABLESS MXR 100/1000MG TAB safe during pregnancy or breastfeeding?

SITABLESS MXR 100/1000MG TAB is generally not recommended for use during pregnancy or while breastfeeding. There is limited information on its safety for a developing baby, and metformin is known to pass into breast milk in small amounts. Your doctor will likely recommend alternative treatments, such as insulin, for managing diabetes during pregnancy.

Can SITABLESS MXR 100/1000MG TAB be taken with other medications?

Yes, it can be taken with some other medications, but certain drug interactions are possible. If taken with insulin or sulfonylureas, there is an increased risk of low blood sugar (hypoglycemia), and your doctor may need to adjust the dosage of those medications. Caution is also advised with diuretics and certain cationic medications (e.g., cimetidine, digoxin, ranitidine, amiloride, morphine). You may need to temporarily stop taking this medication before certain diagnostic tests that use contrast dyes or before major surgery. Always inform your doctor about all other medications, supplements, and herbal products you are taking.

What precautions should be taken while using SITABLESS MXR 100/1000MG TAB?

Regular monitoring of your kidney function is essential while taking this medication. You should limit or avoid excessive alcohol intake, as it can increase the risk of lactic acidosis. Inform your doctor if you have a history of severe breathing problems, heart failure, liver disease, or pancreatitis. If you experience symptoms of lactic acidosis, pancreatitis, or a severe allergic reaction, seek immediate medical attention. Your doctor may also monitor your Vitamin B12 levels during long-term treatment.

What happens if a dose of SITABLESS MXR 100/1000MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should SITABLESS MXR 100/1000MG TAB be stored?

Keep SITABLESS MXR 100/1000MG TAB out of the reach of children. Store the medicine in its original container at room temperature, away from heat, moisture, and direct light.