Provironum 25 Mg Tablet (10 Tab)

PROVIRONUM 25 MG TABLET by ZYDUS HEALTHCARE LIMITED is a medication primarily used in men to address conditions related to androgen deficiency.

Name

• Brand Name: PROVIRONUM 25 MG TABLET, Proviron
• Common Name: Mesterolone

Composition

Each tablet contains 25 mg of Mesterolone as the active ingredient.

Uses

PROVIRONUM is prescribed for men to treat conditions caused by insufficient endogenous androgen formation, such as:

• Low testosterone levels (male hypogonadism)
• Male infertility, particularly due to oligozoospermia (low sperm count) or insufficient Leydig-cell secretion, by improving sperm count and quality.
• Disturbances associated with androgen deficiency, including decreased physical activity, fatigue, lack of concentration, memory issues, reduced libido and potency, irritability, insomnia, and depressive mental states.

Dosage and Administration

PROVIRONUM 25 mg tablets should be taken as directed by a doctor.

• Typical Guidance: Swallow the tablet whole with a glass of water, with or without food. Do not crush, break, or chew the medicine.
• Initial Dose (for androgen deficiency): Typically 1 tablet three times per day.
• Maintenance Dose: May be reduced to 1 tablet once or twice daily after satisfactory improvement.
• For Infertility: Often 1 tablet two to three times per day for approximately 90 days (a spermatogenesis cycle).

Side Effects

Common side effects can include itching, rash, hives, abdominal pain, indigestion, nausea, and vomiting. Serious side effects, though rare, can include:

• Frequent or prolonged erections that are unwanted.
• Liver abnormalities or tumors.
• Changes in urination indicative of prostate issues.
• Enlargement of male breast tissue.
• Increased aggression or depression.

Precautions

• Contraindications: PROVIRONUM is contraindicated in patients with prostate cancer, male breast cancer, liver cancer (past or present), or high levels of calcium in the blood (hypercalcemia).
• For Male Patients Only: This medicine is exclusively for use in male patients and is not indicated for women, particularly during pregnancy or breastfeeding.
• Medical History: Inform your doctor about any history of heart, prostate, liver, kidney disease, high blood pressure, diabetes, migraines, or epilepsy.
• Prostate Examinations: Regular examinations of the prostate are recommended as a precautionary measure during treatment.
• Drug Interactions: Inform your doctor about all other medicines, supplements, or herbal products you are taking.
• Abuse Potential: Mesterolone has been abused in combination with other anabolic-androgenic steroids, carrying serious health risks. Do not exceed the prescribed dose.

Storage

Store PROVIRONUM tablets in a cool and dry place, protected from direct sunlight, moisture, and heat. The temperature should ideally stay below 30°C. Keep it away from children and pets.

Here are frequently asked questions about PROVIRONUM 25 MG TABLET (10 TAB) by ZYDUS HEALTHCARE LIMITED, containing Mesterolone:

What is PROVIRONUM 25 MG TABLET used for?

PROVIRONUM 25 MG TABLET is used in men to treat conditions caused by a deficiency in androgen (male hormone) formation. This includes low testosterone levels in men (male hypogonadism), androgen deficiency, and male infertility, especially when linked to low hormone levels or poor sperm quality (idiopathic oligospermia). It can also help alleviate symptoms associated with androgen deficiency such as decreased physical activity, fatigue, reduced memory and concentration, disturbances in libido and potency, irritability, insomnia, and depressive moods.

How does PROVIRONUM 25 MG TABLET work?

PROVIRONUM 25 MG TABLET contains Mesterolone, a synthetic steroid hormone that acts as an androgen. It works by supplementing the body's natural testosterone levels. Mesterolone also activates androgen receptors, which are vital for the development and maintenance of male characteristics.

What is the usual dosage of PROVIRONUM 25 MG TABLET?

The dosage of PROVIRONUM is determined by your doctor based on your specific medical condition. For initiating treatment for disturbances due to androgen deficiency or to stimulate the development of secondary male sex characteristics, a common starting dose is 1-2 tablets three times per day for several months. For maintenance, a dose of 1 tablet two to three times a day may be sufficient. When used to increase sperm count and improve quality in cases of male infertility, the typical dosage is 1 tablet two to three times daily for approximately 90 days (a complete spermatogenic cycle).

What are the possible side effects of PROVIRONUM 25 MG TABLET?

Common side effects can include headache, acne or pimples, fluid retention or swelling, enlargement of the breast tissue in males (gynecomastia), increased sexual urge or libido, irritability, nervousness, depression, agitation, a feeling of lack of energy, and excessive growth of body hair (hirsutism). More serious but less common side effects can involve liver abnormalities, tumors, changes to blood lipids, and an increased risk of heart disease. If you experience prolonged stomach pain, blood in stools or vomit, or yellowing of the skin and eyes, inform your doctor immediately.

Is PROVIRONUM 25 MG TABLET safe during pregnancy or breastfeeding?

No, PROVIRONUM 25 MG TABLET is strictly indicated for use only in male patients. It is contraindicated for women, including those who are pregnant or breastfeeding.

Can PROVIRONUM 25 MG TABLET be taken with other medications?

PROVIRONUM can interact with certain other medications, potentially affecting how well it or the other medicines work. These include medications for seizures (like phenobarbital or phenytoin), immunosuppressants (such as cyclosporin), antidiabetic medicines (like insulin, metformin, glimepiride), thyroid hormones (e.g., thyroxine), oral anticoagulants (blood thinners like warfarin), and neuromuscular blockers (used in anaesthetics). Always inform your doctor or pharmacist about all other medicines, herbal preparations, and supplements you are taking.

What precautions should be taken while taking PROVIRONUM 25 MG TABLET?

You should not take PROVIRONUM if you have prostate cancer, a history of liver tumors, male breast cancer, or high blood calcium levels. Regular monitoring through blood tests and prostate examinations (e.g., PSA levels) is important during treatment. Use with caution if you have a history of liver disease, kidney disease, heart or blood vessel disease, high blood pressure, diabetes, migraines, epilepsy, or sleep apnea. This medicine is not intended for muscle development or enhancing physical capacity in healthy individuals, as this carries serious health risks.

What happens if a dose of PROVIRONUM 25 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. If you are unsure, consult your doctor or pharmacist.

How should PROVIRONUM 25 MG TABLET be stored?

Store PROVIRONUM tablets in their original packaging in a cool, dry place, keeping the temperature below 30°C. Protect the medicine from direct sunlight, moisture, and heat. It is crucial to keep it out of the sight and reach of children and pets. Do not store it in the bathroom, near a sink, or in the car, as heat and dampness can degrade medicines.