Syncapone 50 Mg Tablet (10 Tab)

SYNCAPONE 50 MG TABLET

Name:

• Brand Name: SYNCAPONE 50 MG TABLET
• Common Name: Levodopa, Carbidopa, and Entacapone

Composition: Each tablet contains:

• Levodopa: 50 mg
• Carbidopa: 12.5 mg
• Entacapone: 200 mg
• Manufacturer: Sun Pharmaceutical Industries Ltd.

Uses: SYNCAPONE 50 MG TABLET is prescribed for the treatment of Parkinson's disease, a neurological disorder affecting movement and coordination. It helps manage symptoms such as tremors, muscle stiffness, difficulty with balance and coordination, and slowness of movement. This medication is particularly beneficial for patients experiencing "end-of-dose wearing-off" effects when on levodopa/carbidopa therapy alone.

Dosage and Administration: This is a prescription medication, and the dosage is determined individually by a healthcare professional based on the patient's condition, age, and body weight. It should be taken orally, either with or without food. However, it is recommended to avoid high-protein meals (e.g., meat, dairy products, eggs, protein powder) as they can impair levodopa absorption. Patients are advised to take the tablet at the same time each day to maintain consistent medication levels. Do not stop taking SYNCAPONE 50 MG TABLET suddenly without consulting a doctor, as abrupt discontinuation can have harmful effects. If a dose is missed, it should be taken as soon as remembered, but skipping doses should be avoided. The maximum recommended daily dose of entacapone is 2,000 mg.

Side Effects: Common side effects may include nausea, vomiting, constipation, discoloration of urine, dry mouth, dizziness, sleepiness, diarrhea, headache, insomnia, anxiety, abnormal dreams, and involuntary muscle movements (dyskinesia).

Serious side effects, though less common, can include severe muscle pain, confusion, high fever, hallucinations, suicidal thoughts, uncontrolled movements, severe diarrhea, or signs of muscle breakdown such as dark urine. Low blood pressure upon standing (orthostatic hypotension) and Neuroleptic Malignant Syndrome (NMS) are also possible.

Precautions:

• Allergies: Do not take if allergic to levodopa, carbidopa, entacapone, or any other components of the tablet.
• Medical Conditions: Inform your doctor about any history of narrow-angle glaucoma, liver or kidney disease, diabetes, heart issues, mental illness, or recent surgeries.
• Drug Interactions: This medicine should not be used with nonselective monoamine oxidase inhibitors (MAOIs); these should be stopped at least 14 days prior. Inform your doctor about all other medications being taken to avoid potential interactions, especially those for high blood pressure or depression.
• Driving and Machinery: May cause dizziness or sleepiness; do not drive or operate machinery until you know how the medicine affects you.
• Pregnancy and Breastfeeding: Consult a doctor. Generally, it is advised to avoid use during pregnancy and breastfeeding unless prescribed by a healthcare provider.
• Alcohol: Consumption of alcohol is not recommended as it may increase the risk of adverse effects such as drowsiness, dizziness, and confusion.
• Diet: Avoid high-protein meals as they can reduce the absorption and efficacy of the medication.

Storage: Store at room temperature (20-25°C) and protect from moisture and light. Keep out of the sight and reach of children.

What is SYNCAPONE 50 MG TABLET used for?

SYNCAPONE 50 MG TABLET is primarily used to manage the symptoms of Parkinson's disease. These symptoms can include tremors, muscle stiffness, poor muscle control, and slowness of movement. It is also beneficial for patients experiencing "wearing-off" effects with levodopa/carbidopa therapy alone, helping to improve overall mobility and quality of life.

How does SYNCAPONE 50 MG TABLET work?

SYNCAPONE 50 MG TABLET is a combination medication containing Levodopa, Carbidopa, and Entacapone. Levodopa is converted into dopamine in the brain, replacing the dopamine deficit seen in Parkinson's disease, which helps control movement. Carbidopa prevents the breakdown of Levodopa in the bloodstream before it reaches the brain, ensuring more of it is available. Entacapone prolongs the effect of Levodopa by inhibiting an enzyme that breaks it down, leading to higher and more sustained levels of Levodopa in the blood and brain.

What is the usual dosage for SYNCAPONE 50 MG TABLET?

The dosage of SYNCAPONE 50 MG TABLET is determined by your doctor based on your condition and response to treatment. It is usually taken orally as directed by your doctor. Patients should take only one tablet per dose administration. The optimal daily dose is determined by careful titration of levodopa for each patient.

What are the possible side effects of SYNCAPONE 50 MG TABLET?

Common side effects can include uncontrolled body movements (dyskinesia), nausea, vomiting, diarrhea, discoloration of urine (reddish-brown), headache, dizziness, drowsiness, dry mouth, and difficulty sleeping (insomnia). More serious, though less common, side effects can include hallucinations, depression (possibly with suicidal thoughts), orthostatic hypotension (sudden drop in blood pressure upon standing), and severe muscle pain.

Is SYNCAPONE 50 MG TABLET safe during pregnancy or breastfeeding?

SYNCAPONE 50 MG TABLET is generally not recommended for use during pregnancy or while breastfeeding unless absolutely necessary, and only after consulting your doctor. Animal studies have shown adverse effects on the fetus, and limited human data suggest potential risks to the baby during breastfeeding. Your doctor will weigh the potential risks and benefits.

Can SYNCAPONE 50 MG TABLET be taken with other medications?

There are several potential drug interactions with SYNCAPONE 50 MG TABLET. It is crucial to inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medicines, and herbal supplements. Concomitant use with non-selective monoamine oxidase inhibitors (MAOIs) is not recommended. Caution is also advised with hypotensive drugs, phenytoin, papaverine, and iron salts as they may reduce the efficacy or increase the risk of side effects.

What precautions should be taken while taking SYNCAPONE 50 MG TABLET?

You should avoid or limit alcohol consumption while taking this medication as it can worsen side effects like drowsiness and dizziness. Avoid consuming high-protein meals as they can reduce the absorption of Levodopa. Do not drive or operate machinery if you experience dizziness, drowsiness, or sudden sleepiness. Use with caution if you have a history of cardiovascular disease, peptic ulcers, glaucoma, liver, or kidney disease, or a history of melanoma. It is important not to stop taking this medication suddenly without consulting your doctor, as abrupt discontinuation can lead to a worsening of symptoms.

What happens if a dose of SYNCAPONE 50 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How should SYNCAPONE 50 MG TABLET be stored?

SYNCAPONE 50 MG TABLET should be stored at room temperature (between 20-25°C) and protected from moisture and light. Keep it out of the reach of children and pets.