Dapanova Sm 500 Tab

DAPANOVA SM 500 Tablet

Name

Brand Name: Dapanova-SM 500 Tablet Common Name: Dapagliflozin, Sitagliptin, and Metformin combination tablet.

Composition

Each DAPANOVA SM 500 Tablet contains a combination of three active ingredients:

• Dapagliflozin (10 mg)
• Metformin (500 mg)
• Sitagliptin (100 mg)

Uses

Dapanova-SM 500 Tablet is an antidiabetic medicine primarily used in the treatment of Type 2 Diabetes Mellitus in adults. It is prescribed as an adjunct to diet and exercise to improve blood sugar control.

It works by:

• Dapagliflozin: Removing excess sugar from the body via urine.
• Sitagliptin: Increasing the amounts of certain natural substances that lower blood sugar when it is high.
• Metformin: Reducing sugar production by cells in the liver and delaying sugar absorption from the intestines, while also improving the body's sensitivity to insulin.

Additionally, this medicine helps lower the risk of heart failure and diabetic kidney disease, and can support weight loss and improve metabolic health in overweight or obese diabetic patients. It effectively lowers HbA1c levels and helps maintain steady blood sugar throughout the day.

Dosage and Administration

Dapanova-SM 500 Tablet should be taken as advised by your doctor. It can be taken with or without food, but it is recommended to take it at the same time every day for optimal benefits. The tablet should be swallowed whole with a glass of water and not crushed, broken, or chewed. Do not exceed the prescribed dose or stop taking it without consulting your doctor, as this may increase blood sugar levels and the risk of serious complications.

Side Effects

Common Side Effects:

• Urinary tract infections (UTIs)
• Genital infections (e.g., genital fungal infection)
• Nasal congestion (common cold, nasopharyngitis)
• Sore throat
• Upper respiratory tract infections
• Headache
• Nausea
• Diarrhea
• Abdominal pain/discomfort
• Influenza
• Back pain
• Cough

Serious Side Effects (Seek immediate medical attention if experienced):

• Signs of lactic acidosis (weakness, difficulty breathing, stomach pain)
• Symptoms of ketoacidosis (nausea, vomiting, confusion, fruity breath)
• Painful or persistent genital or urinary infections
• Signs of pancreatitis (severe stomach pain, nausea)
• Allergic reactions (rash, swelling, breathing problems)

Precautions

• Allergies: Avoid if allergic to Dapagliflozin, Sitagliptin, Metformin, or any other components of the tablet.
• Kidney/Liver Disease: Not recommended for patients with severe liver or kidney disease, end-stage renal disease (ESRD), or those on dialysis due to increased risk of lactic acidosis. Caution is advised for patients with kidney problems, and dosage adjustment may be necessary.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or planning pregnancy, as there is limited information on its use during pregnancy. It is generally not recommended during breastfeeding due to the presence of metformin in human milk.
• Alcohol Consumption: Avoid excessive alcohol intake, as it can increase the risk of lactic acidosis and other side effects.
• Dehydration: Drink plenty of fluids to prevent dehydration, especially as dapagliflozin increases glucose excretion through urine.
• Other Medications: Inform your doctor about all medications, herbs, and supplements you are taking. Interactions can occur with diuretics (e.g., furosemide, hydrochlorothiazide), insulin, and insulin secretagogues (e.g., glimepiride), which may increase the risk of hypoglycemia.
• Diabetic Ketoacidosis/Metabolic Acidosis: Not for use in Type 1 Diabetes, diabetic ketoacidosis, or metabolic acidosis.
• Children: Not recommended for use in children below 18 years of age.
• Driving: May decrease alertness, affect vision, or cause sleepiness/dizziness; exercise caution when driving or operating machinery.
• Hygiene: Maintain good genital hygiene to help prevent fungal infections.

Storage

Store in a cool and dry place away from direct sunlight. Keep Dapanova-SM 500 Tablet out of the sight and reach of children. It should be stored at a consistent temperature below 30°C or between 10ºC to 25ºC.

What is DAPANOVA SM 500 TAB used for?

DAPANOVA SM 500 TAB is an antidiabetic medicine primarily used to manage Type 2 Diabetes Mellitus in adults. It works as an adjunct to diet and exercise to improve blood sugar control. Additionally, it may help in weight management, reduce HbA1c levels, and offer cardiovascular and kidney protection in some individuals.

How does DAPANOVA SM 500 TAB work?

This medicine contains a combination of three active ingredients: Dapagliflozin, Sitagliptin, and Metformin. Dapagliflozin helps remove excess sugar from the body through urine. Sitagliptin increases the levels of natural substances in the body that lower blood sugar when it's high. Metformin reduces sugar production by the liver cells, delays sugar absorption from the intestines, and enhances the body's sensitivity to insulin.

What is the usual dosage for DAPANOVA SM 500 TAB?

The dosage of DAPANOVA SM 500 TAB should be taken exactly as advised by your doctor. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal benefits. The tablet should be swallowed whole and not crushed, broken, or chewed.

What are the possible side effects of DAPANOVA SM 500 TAB?

Common side effects can include genital infections, common cold, diarrhea, headache, nausea, influenza, back pain, cough, urinary tract infections, and sore throat. Serious but rare side effects to watch for include signs of lactic acidosis (weakness, difficulty breathing, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), painful or persistent genital/urinary infections, signs of pancreatitis (severe stomach pain), or allergic reactions (rash, swelling). Most common side effects are usually temporary and resolve over time.

Is DAPANOVA SM 500 TAB safe during pregnancy or breastfeeding?

DAPANOVA SM 500 TAB is generally not recommended during pregnancy or breastfeeding. There is limited information on its effects in pregnant women, and metformin, one of its components, is known to pass into human breast milk. It is crucial to inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medicine.

Can DAPANOVA SM 500 TAB be taken with other medications?

DAPANOVA SM 500 TAB can interact with several other medications. Inform your doctor about all medicines, including herbs and supplements, you are currently taking. Particular caution is advised with diuretics (water pills), insulin and insulin secretagogues (like sulfonylureas), blood pressure medications, steroids, and certain drugs for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), or HIV/AIDS (e.g., ritonavir). It can increase the risk of hypoglycemia when taken with other antidiabetic medicines.

What precautions should be taken while taking DAPANOVA SM 500 TAB?

Avoid taking this medicine if you have Type 1 diabetes, diabetic ketoacidosis, severe liver or kidney disease, or metabolic acidosis. Use with caution if you have hepatic insufficiency, renal impairment, or heart failure. It is advised to avoid excessive alcohol consumption as it can increase the risk of side effects like lactic acidosis. Maintaining good hygiene can help prevent genital fungal infections. Regular monitoring of blood sugar levels and kidney function is important during treatment.

What happens if a dose of DAPANOVA SM 500 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you frequently miss doses, consult your doctor.

How should DAPANOVA SM 500 TAB be stored?

DAPANOVA SM 500 TAB should be stored in a cool and dry place, away from direct sunlight. It should be kept out of the sight and reach of children, typically at temperatures between 10ºC to 25ºC or below 30ºC.