Matilda Pg Er

MATILDA PG ER by LUPIN LTD

MATILDA PG ER is a prescription medication manufactured by Lupin Ltd, primarily used to manage neuropathic pain.

• Name

  • Brand Name: MATILDA PG ER

• Composition

  • MATILDA PG ER contains a combination of two active ingredients: Methylcobalamin (1500mcg) and Pregabalin (75mg). Methylcobalamin is a form of Vitamin B12 that aids in nerve regeneration and protection by producing myelin, a protective layer around nerve fibers. Pregabalin is an anticonvulsant that works by modulating calcium channel activity in nerve cells, thereby reducing pain signals from damaged nerves.

• Uses

  • This medicine is prescribed for the treatment of neuropathic pain, which is chronic pain resulting from nerve damage or dysfunction.
  • It is effective in managing conditions such as:
    • Diabetic peripheral neuropathy
    • Post-herpetic neuralgia (pain after shingles)
    • Trigeminal neuralgia
    • Pain resulting from spinal cord injury
    • Multiple sclerosis
    • Chemotherapy-induced neuropathy
  • MATILDA PG ER helps to reduce pain, associated mood changes, sleep problems, and tiredness, improving overall quality of life.

• Dosage and Administration

  • MATILDA PG ER should be taken orally exactly as prescribed by your doctor.
  • It can be taken with or without food, preferably at bedtime.
  • To maintain a consistent level of medicine in the body, it is advised to take it at the same time each day.
  • Swallow the tablet whole with water; do not crush, chew, or break it.
  • Do not stop taking this medication abruptly without consulting your doctor, as gradual dose reduction is necessary to prevent withdrawal symptoms.

• Side Effects

  • Common Side Effects: Dizziness, sleepiness/drowsiness, headache, dry mouth, blurred vision, increased appetite, nasopharyngitis, tremor, tiredness, uncoordinated body movements, constipation, nausea, vomiting, diarrhea, loss of appetite, mood changes, fluid retention, and weight gain. These side effects are usually mild and may improve over time.
  • Serious Side Effects (Seek medical attention if experienced): Allergic reactions (e.g., bumps, swelling, itching, difficulty breathing), worsening depression, suicidal thoughts, heart failure (in patients with heart disease), kidney failure (indicated by decreased urination), and convulsions upon sudden discontinuation.

• Precautions

  • Inform your doctor if you have any allergies to the components of MATILDA PG ER.
  • Exercise caution and inform your doctor if you have a history of heart disease, liver or kidney problems, fits, alcoholism, drug abuse, or low vitamin B12 levels.
  • Pregnancy and Breastfeeding: MATILDA PG ER is generally not advised during pregnancy or breastfeeding, as it may be unsafe and can pass into breast milk. Women of childbearing age should use effective contraception if prescribed.
  • Alcohol: Avoid alcohol consumption as it can increase the risk of dizziness and drowsiness.
  • Driving and Operating Machinery: Due to potential dizziness, drowsiness, or blurred vision, avoid driving or operating heavy machinery until you understand how the medicine affects you.
  • Elderly Patients: Caution is advised in elderly patients due to an increased risk of accidental injury (falls).
  • MATILDA PG ER is not recommended for individuals under 18 years of age.
  • Report any unusual mood or behavioral changes, worsening depression, or suicidal thoughts to your doctor immediately.
  • Patients with diabetes who experience weight gain while on this medication may require adjustments to their diabetic treatment.
  • This tablet contains lactose, so individuals with sugar intolerance should inform their doctor.

• Storage

  • Store MATILDA PG ER in a cool, dry place, ideally below 25°C.
  • Protect the medicine from direct sunlight, heat, and moisture.
  • Keep it out of the sight and reach of children.
  • Always check the expiration date and use the medicine before that date.
  • Dispose of any unused medication properly.

What is MATILDA PG ER used for?

MATILDA PG ER is primarily used to manage neuropathic pain, which is pain caused by damage or dysfunction of nerves. It is prescribed for conditions such as diabetic peripheral neuropathy, post-herpetic neuralgia (pain after shingles), trigeminal neuralgia, pain resulting from spinal cord injury, multiple sclerosis, and chemotherapy-induced neuropathy. This medication helps reduce pain and associated symptoms like mood changes, sleep problems, and tiredness.

How does MATILDA PG ER work?

MATILDA PG ER contains two active ingredients: Pregabalin and Methylcobalamin. Pregabalin is an anticonvulsant that works by binding to calcium channels in the brain, which reduces the release of neurotransmitters responsible for sending pain signals, thus decreasing pain sensation. Methylcobalamin, a form of Vitamin B12, aids in the production of myelin (a protective covering for nerve fibers), promotes the regeneration of damaged nerve cells, and supports overall nerve health. These two components work together to provide effective relief from nerve pain.

What is the usual dosage for MATILDA PG ER?

The dosage of MATILDA PG ER should be strictly followed as prescribed by your doctor, as it can vary based on the severity of your condition and your response to the medication. It is generally recommended to take one tablet twice a day, orally with water. The tablet should be swallowed whole and not crushed, chewed, or broken. It can be taken with or without food, preferably at bedtime, to maintain a consistent level of medicine in the body.

What are the possible side effects of MATILDA PG ER?

Common side effects of MATILDA PG ER include dizziness, drowsiness, headache, dry mouth, constipation, blurred vision, increased appetite, weight gain, mood changes, sleep disturbances, fatigue, and uncoordinated body movements. Some individuals might also experience nausea, vomiting, diarrhea, loss of appetite, hot sensations, or sweating. Most side effects are typically mild and temporary, resolving as your body adjusts to the medication. If any side effects persist or worsen, it is important to consult your doctor.

Is MATILDA PG ER safe during pregnancy or breastfeeding?

Pregnancy: Caution is advised when taking MATILDA PG ER during pregnancy, as there is limited data on its safety and it may pose a risk to the fetus. It should only be used if the potential benefits clearly outweigh the risks, and only under a doctor's prescription. Women of childbearing age are typically advised to use effective contraception while on this medication.

Breastfeeding: MATILDA PG ER is generally not recommended during breastfeeding as its components can pass into human milk and may harm the nursing infant. Your doctor will assess the benefits and risks to determine whether to discontinue breastfeeding or the medication.

Can MATILDA PG ER be taken with other medications?

MATILDA PG ER can interact with certain other medications. It may amplify the sedative effects of Central Nervous System (CNS) depressants, such as opioids (e.g., morphine), benzodiazepines (e.g., alprazolam), and barbiturates, leading to increased drowsiness and potential respiratory depression. Taking it with diabetes medications like thiazolidinediones (e.g., pioglitazone) may lead to weight gain and fluid retention, potentially worsening heart failure in some patients. Inform your doctor about all medicines, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions. Specific interactions with Methylcobalamin include chloramphenicol, omeprazole, and goldenseal. Alcohol consumption should be avoided as it can increase side effects like dizziness and drowsiness.

What precautions should be taken while taking MATILDA PG ER?

Several precautions should be observed:

• Kidney Issues: Use with caution if you have severe kidney problems, as pregabalin is primarily eliminated through the kidneys.
• Heart Conditions: Patients with heart failure should be closely monitored as the medicine can cause peripheral edema (swelling) and weight gain, which might worsen their condition.
• Liver Concerns: Discuss any liver issues with your doctor before starting treatment, as the medicine may impact liver function.
• Allergies: Do not take if you are allergic to methylcobalamin or pregabalin.
• Driving & Machinery: Avoid driving or operating heavy machinery if you experience dizziness, drowsiness, or blurred vision.
• Sudden Discontinuation: Do not stop taking the medication abruptly without consulting your doctor, as this can lead to withdrawal symptoms such as anxiety, sleep difficulties, nausea, pain, and sweating. A gradual tapering of the dose is often necessary.
• Weight Management: To counter potential weight gain, maintain a regular exercise regimen and a balanced diet.
• Mood Changes: Report any unusual changes in mood, worsening depression, or suicidal thoughts to your doctor.
• It is not suitable for individuals under 18 years of age.

What happens if a dose of MATILDA PG ER is missed?

If you miss a dose of MATILDA PG ER, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects. It is important not to alter your dosage without consulting your doctor.

How should MATILDA PG ER be stored?

MATILDA PG ER should be stored at room temperature, ideally below 25°C. Keep the medicine protected from moisture and light to maintain its effectiveness. Always ensure it is kept out of the reach of children. Check the expiration date on the packaging and use the medicine before that date.