Idofnib 100mg Cap

IDOFNIB 100MG CAP by LUPIN LTD

Name

• Brand Name: Idofnib 100 MG Capsule, Idofnib 100mg Soft Gelatin Capsule
• Common Name: Nintedanib Capsule

Composition

• Active Ingredient: Nintedanib 100mg

Uses

Idofnib 100 MG Capsule is primarily prescribed for adults to treat a range of lung conditions and certain cancers. It is a tyrosine kinase inhibitor that works by reducing the activity of enzymes that contribute to scarring and abnormal cell growth.

• Idiopathic Pulmonary Fibrosis (IPF): A rare, chronic lung disease characterized by scarring in the lungs, leading to a progressive decline in lung function.
• Non-Small Cell Lung Cancer (NSCLC): Specifically, advanced non-small cell lung cancer of adenocarcinoma type, often used in combination with other anticancer medications like docetaxel or after first-line chemotherapy failure.
• Chronic Fibrosing Interstitial Lung Diseases: With a progressive phenotype.
• Systemic Sclerosis-Associated Interstitial Lung Disease:

Dosage and Administration

Idofnib 100 MG Capsule should be taken orally with food to enhance its effectiveness and minimize gastrointestinal side effects.

• Typical Guidance: Swallow the capsule whole with water; do not cut, break, or chew it.
• Timing: It is best taken at a fixed time every day for optimal results.
• Dosage: The dosage and schedule are determined by a doctor and may be adjusted based on the patient's specific condition and response to treatment.
• Do not consume more than prescribed.

Side Effects

While generally temporary, some side effects may require medical attention.

• Common Side Effects: Diarrhea (very common), nausea, vomiting, abdominal pain, headache, decreased appetite, weight loss, high blood pressure (hypertension), elevated liver enzymes, indigestion, and tiredness.
• Serious Side Effects (less common): Bleeding events, gastrointestinal perforation, arterial thromboembolic events (e.g., myocardial infarction), skin ulcer, pancreatitis, and drug-induced liver injury.

Precautions

• Pregnancy: Contraindicated during pregnancy due to potential harm to the unborn baby. Women of childbearing potential should use effective contraception during treatment and for a month after.
• Breastfeeding: Not recommended as the medicine may pass into breast milk and harm the infant.
• Liver/Kidney Problems: Use with caution; regular monitoring of liver enzymes is important. Not recommended for moderate to severe liver diseases.
• Bleeding Problems: Inform your doctor if you have a bleeding problem, as Idofnib can increase the risk of bleeding, especially if taken with blood thinners.
• Alcohol: Doctor consultation is advised regarding alcohol consumption during treatment.
• Drug Interactions: Inform your doctor about all medications, supplements, or herbal products. Certain medicines, including anti-infectives (e.g., erythromycin, rifampicin), anticonvulsants (e.g., phenytoin, carbamazepine), anticoagulants (e.g., warfarin, heparin), antifungals (e.g., ketoconazole, itraconazole), and St. John's wort, can interact with Idofnib.
• Food Interactions: Avoid grape juice and grapes.
• Driving/Operating Machinery: May cause tiredness or dizziness, so caution is advised.

Storage

• Store below 25°C or 30°C.
• Protect from light and moisture.
• Keep out of the reach and sight of children and pets.

What is IDOFNIB 100MG CAP used for?

IDOFNIB 100MG CAP, which contains the active ingredient Nintedanib 100mg, is primarily used to treat idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring in the lungs. It is also used to manage chronic fibrosing interstitial lung diseases with a progressive phenotype and systemic sclerosis-associated interstitial lung disease. Additionally, it can be prescribed for advanced non-small cell lung cancer of the adenocarcinoma type, especially after first-line chemotherapy has not been effective.

How does IDOFNIB 100MG CAP work?

IDOFNIB 100MG CAP is an anti-cancer medication and an anti-fibrotic agent belonging to a class known as tyrosine kinase inhibitors (TKIs). It works by blocking the action of abnormal proteins that signal cancer cells to multiply. It also inhibits specific enzymes involved in pathways that lead to fibrosis, which is the thickening or scarring of tissues in the lungs. By doing so, it helps to slow down the progression of lung scarring and the spread of cancer cells.

What is the usual dosage of IDOFNIB 100MG CAP?

The usual recommended dosage for conditions like idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease is 100mg, taken orally with food, twice a day. It's important to take it exactly as prescribed by your doctor, preferably at the same time each day, and always with food. Your doctor will determine the appropriate dose and duration of treatment based on your specific condition.

What are the possible side effects of IDOFNIB 100MG CAP?

Common side effects can include diarrhea, nausea, vomiting, abdominal pain, abnormal liver function tests, loss of appetite, headache, weight loss, and high blood pressure. Diarrhea is a very common side effect; it's advised to drink plenty of fluids and inform your doctor if it persists. More serious, though less common, side effects can include bleeding events, skin ulcers, and arterial thromboembolic events (like heart attack or stroke).

Is IDOFNIB 100MG CAP safe during pregnancy or breastfeeding?

No, IDOFNIB 100MG CAP is considered unsafe during pregnancy as there is clear evidence of risk to the developing baby. Women who are of childbearing potential should use reliable methods of contraception during treatment and for at least one month after stopping the medication. It is also probably unsafe to use during breastfeeding, as limited human data suggests the drug may pass into breast milk and could harm the baby.

Can IDOFNIB 100MG CAP be taken with other medications?

Many medications can interact with IDOFNIB 100MG CAP, affecting how it works or increasing the risk of side effects. It is crucial to inform your doctor about all prescription and over-the-counter medications, supplements, and herbal products you are taking. For example, blood thinners (like warfarin) can increase the risk of bleeding. Certain antifungals (like ketoconazole) and antibiotics (like erythromycin) may increase Idofnib levels, while anticonvulsants (like phenytoin) and rifampicin can decrease its effectiveness. You should also avoid consuming grape or grape juice while on this medication.

What precautions should be taken while using IDOFNIB 100MG CAP?

Before taking IDOFNIB 100MG CAP, inform your doctor if you have any bleeding problems, or liver or kidney conditions. Your doctor may request blood tests to monitor your liver function regularly during treatment. You should also monitor your blood pressure regularly. Due to potential side effects like headache, dizziness, or sleepiness, caution is advised when driving or operating heavy machinery. This medication is not recommended for children under 18 years of age.

What happens if a dose of IDOFNIB 100MG CAP is missed?

If you miss a dose, you can take it if you remember within 6 hours. However, if it has been more than 6 hours since the missed dose, you should skip it and continue with your next scheduled dose at the regular time. Do not take a double dose to make up for a forgotten one, as this can increase the risk of side effects.

How should IDOFNIB 100MG CAP be stored?

IDOFNIB 100MG CAP should be stored below 25°C or 30°C. Keep it in a cool, dry place, protected from light and moisture. Always keep the medicine out of the reach and sight of children and pets.