Lariago Syp

Lariago Syrup is an antimalarial and anti-amoebic medication manufactured by IPCA Intima.

Name

• Common Name: Chloroquine Phosphate
• Brand Name: LARIAGO SYP

Composition

Lariago Syrup primarily contains Chloroquine Phosphate, often in concentrations such as 50 mg/5 ml or 250 mg/5 ml.

Uses

Lariago Syrup is prescribed for the treatment and prevention of various parasitic infections. Its main uses include:

• Malaria: Effective against susceptible strains of Plasmodium falciparum, P. vivax, P. malariae, and P. ovale. It works by interfering with the parasite's ability to break down haemoglobin in infected red blood cells, leading to toxic build-up and parasite death.
• Amebiasis: Particularly used for hepatic infections caused by Entamoeba histolytica.
• It may also be used for certain rheumatological disorders such as rheumatoid arthritis and systemic lupus erythematosus.

Dosage and Administration

The dosage of Lariago Syrup varies based on the patient's age, weight, and the specific condition being treated, and should be strictly followed as prescribed by a healthcare professional. It is administered orally using a measuring cup or spoon. The syrup can generally be taken with or without food. It is crucial to complete the full course of medication even if symptoms improve.

Side Effects

Common side effects may include:

• Headache
• Nausea, vomiting, stomach pain, diarrhea, loss of appetite
• Dizziness
• Rashes, itching

More serious, though less common, side effects include:

• Changes in vision (blurred vision, light sensitivity, trouble reading)
• Seizures, hallucinations
• Muscle weakness
• Serious heart problems, including irregular heart rhythm
• Low blood sugar levels
• Blood cell abnormalities
• Hearing problems

Precautions

• Allergies: Do not take if allergic to chloroquine or any other ingredients in Lariago Syrup.
• Pre-existing Conditions: Inform your doctor if you have liver, heart, kidney issues, diabetes, psoriasis, epilepsy or other seizure disorders, or a history of eye or hearing problems.
• Drug Interactions: Caution is advised when taken with other medications, especially those affecting heart rhythm (e.g., amiodarone, procainamide, moxifloxacin), other antimalarials, immunosuppressants (e.g., ciclosporin), anti-epileptic medicines, antacids, and certain vaccines (e.g., rabies, oral typhoid).
• Pregnancy and Breastfeeding: Use with caution and only if the potential benefits outweigh the risks; consult your doctor.
• Children: Should only be used if prescribed by a doctor, with careful dose calculation based on weight and age.
• Driving and Machinery: Avoid driving or operating heavy machinery if you experience dizziness or visual disturbances.
• Avoid long-term or high doses due to potential retinal damage and permanent vision problems.

Storage

Store Lariago Syrup in a cool and dry place, away from direct sunlight, typically below 25°C or 30°C. Keep out of the sight and reach of children.

Lariago Syrup, with its active ingredient Chloroquine Phosphate, is primarily an antimalarial medication used to treat and prevent malaria, and also to manage amebiasis.

Here are some frequently asked questions about Lariago Syrup:

What is Lariago Syrup used for?

Lariago Syrup is primarily used for the treatment and prevention of malaria, a life-threatening disease caused by Plasmodium parasites transmitted through mosquito bites. It is effective against various Plasmodium strains, including P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. Additionally, it is used to treat amebiasis, particularly liver infections caused by Entamoeba histolytica.

How does Lariago Syrup work?

Lariago Syrup contains chloroquine, which works by entering red blood cells infected by parasites. Inside the parasites, it interferes with their ability to break down hemoglobin, leading to a toxic buildup and ultimately causing the death of the parasite. In malaria, it targets the parasites during their blood stage, while in amebiasis, it accumulates in the liver to act against Entamoeba histolytica.

What is the usual dosage for Lariago Syrup?

The dosage of Lariago Syrup is determined by your doctor, taking into account your medical condition, age, and weight. It is crucial to follow your doctor's instructions precisely and not to exceed the prescribed dose. For children, the dosage is often based on body weight. Lariago Syrup can be taken with or without food, but taking it with food may help reduce stomach upset. Always use a measuring cup or spoon provided with the medication for accurate dosing.

What are the possible side effects of Lariago Syrup?

Common side effects may include headache, nausea, vomiting, loss of appetite, stomach pain, diarrhea, rash, itching, and increased sensitivity to light (photosensitivity). More serious, though less common, side effects can include changes in vision (such as blurred vision, light sensitivity, or difficulty reading), seizures, hallucinations, muscle weakness, and dizziness. If you experience blurred vision, light sensitivity, or difficulty reading, contact your doctor immediately.

Is Lariago Syrup safe during pregnancy or breastfeeding?

Pregnancy: Lariago Syrup is generally considered safe for malaria prevention and treatment during pregnancy if clearly needed. Your doctor will weigh the benefits against potential risks to the fetus before prescribing it. Uncontrolled malaria during pregnancy can pose serious risks to both the mother and baby. Breastfeeding: Chloroquine, the active ingredient, passes into breast milk. While some sources suggest it's generally safe for breastfeeding mothers, others recommend it only if absolutely necessary and under a doctor's guidance. It is important to consult your doctor if you are breastfeeding before taking this medicine.

Can Lariago Syrup be taken with other medications?

Lariago Syrup can interact with various medications. It should be used with caution, or avoided, with other drugs that affect heart rhythm (e.g., amiodarone, moxifloxacin, ciprofloxacin) as this can lead to serious heart problems. It can also interact with immunosuppressants like ciclosporin, anti-epileptic medicines, and certain antibiotics. Antacids should not be taken within 4 hours of Lariago Syrup as they may interfere with its absorption. Inform your doctor about all medications, including over-the-counter drugs and herbal remedies, you are currently taking.

What precautions should be taken while using Lariago Syrup?

Inform your doctor about any pre-existing medical conditions, especially eye problems (such as retinal damage or visual field changes), liver, heart, or kidney issues, diabetes, psoriasis, blood disorders (like porphyria or G6PD deficiency), or epilepsy/seizure disorders. Avoid long-term or high doses of Lariago Syrup as it can potentially damage the retina of your eye, leading to permanent vision problems. Since it may cause dizziness and blurred vision, avoid driving or operating heavy machinery until you understand how the medicine affects you. It is crucial to complete the full prescribed course of treatment, even if you start feeling better, to prevent treatment failure and recurrence of infection.

What happens if a dose of Lariago Syrup is missed?

If you miss a dose of Lariago Syrup, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can lead to overdose. Missing a dose of anti-malarial medicine can sometimes lead to treatment failure.

How should Lariago Syrup be stored?

Lariago Syrup should be stored in a cool and dry place, typically below 25°C or 30°C, away from direct sunlight and moisture. Keep the bottle tightly closed and out of the reach and sight of children. Do not use the medicine after the expiry date.