Trenaxa Mf ( 10 Tab )

TRENAXA MF (10 TAB) by MACLEODS PHARMACEUTICALS PVT LTD

TRENAXA MF is a combination medicine manufactured by Macleods Pharmaceuticals Pvt Ltd, primarily used to address heavy menstrual bleeding and associated pain.

• Name:

  • Brand Name: Trenaxa MF
  • Common Name: Tranexamic Acid and Mefenamic Acid Tablets

• Composition: TRENAXA MF contains a fixed-dose combination of two active ingredients:

  • Tranexamic Acid (500 mg)
  • Mefenamic Acid (250 mg)

  Tranexamic acid is an antifibrinolytic, which helps reduce excessive bleeding by preventing the breakdown of blood clots. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, thereby reducing pain, inflammation, and menstrual cramps.

• Uses: TRENAXA MF is prescribed for:

  • Heavy menstrual bleeding (menorrhagia)
  • Relief from menstrual pain and cramps (dysmenorrhea)
  • May also be used for other conditions involving mild to moderate pain and excessive bleeding as recommended by a healthcare provider.

• Dosage and Administration:

  • TRENAXA MF tablets should be taken orally with or after food to avoid stomach upset.
  • The typical dosage and duration are as directed by a doctor, based on individual needs and medical condition.
  • It is often recommended to take it on the first day of menstruation to maximize benefit.
  • Do not exceed the recommended dosage.

• Side Effects: Common side effects may include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Stomach pain or discomfort
  • Dizziness
  • Backache
  • Heartburn, indigestion
  • Nasal congestion (stuffy nose), sinus pain/inflammation

  Serious side effects, though rare, can include allergic reactions, severe abdominal pain, or blood in urine.

• Precautions:

  • Pregnancy and Breastfeeding: Generally not recommended during pregnancy, especially in the last trimester, as it may cause harm to the fetus, delay labor, and increase the risk of bleeding. It is advised not to breastfeed during treatment as components can pass into breast milk. Consult a doctor.
  • Allergies: Avoid if allergic to Mefenamic acid, Tranexamic acid, or any other ingredients.
  • Medical Conditions: Use with caution or avoid if you have a history of:
    • Blood clotting disorders or active intravascular clotting.
    • Stomach or intestinal bleeding/ulcers due to painkillers.
    • Liver, kidney, or heart function problems.
    • Epilepsy, seizures (fits), or a history of convulsions.
    • Irregular menstrual bleeding patterns.
    • Visual disturbances (discontinue use immediately if they occur).
  • Drug Interactions: Inform your doctor about all medications, herbal preparations, and supplements being taken. Avoid concomitant use with other painkillers or anti-inflammatory medicines. Interactions may occur with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., clopidogrel), certain antidiabetic medicines, mifepristone, digoxin, blood pressure-lowering medicines, immunomodulators (e.g., tacrolimus), anti-HIV medicines (e.g., zidovudine), probenecid, and some antibiotics.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of stomach bleeding, dizziness, or drowsiness.
  • Driving and Operating Machinery: May cause dizziness, drowsiness, fatigue, and visual disturbances; exercise caution.

• Storage:

  • Store at room temperature (20-25°C), ideally below 30°C.
  • Protect from moisture and direct light.
  • Keep out of sight and reach of children.
  • Ensure the medication is used before its expiry date.

Frequently Asked Questions about TRENAXA MF

What is TRENAXA MF used for?

TRENAXA MF is a combination medicine primarily used to treat heavy menstrual bleeding (menorrhagia) and relieve pain and cramps in the lower abdomen before and during menstrual periods (dysmenorrhea). It may also be used for other conditions involving mild to moderate pain and excessive bleeding, and to manage severe blood loss, swelling, fever, inflammation, and migraine headaches.

How does TRENAXA MF work?

TRENAXA MF works through the combined action of its two components: Tranexamic acid and Mefenamic acid. Tranexamic acid is an anti-fibrinolytic that helps reduce excessive bleeding by improving blood clotting and preventing the breakdown of blood clots. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of certain chemical messengers called prostaglandins, which are responsible for causing pain and inflammation.

What is the usual dosage of TRENAXA MF?

The dosage and duration of treatment for TRENAXA MF will vary based on individual needs and medical condition, and should be taken as directed by your doctor. It is typically recommended to take one tablet (containing 500 mg Tranexamic Acid and 250 mg Mefenamic Acid) three times a day. Medication intake should begin on the first day of menstruation and continue for 3-5 days or until heavy bleeding stops, but for no more than 5 consecutive days per menstrual cycle. The tablet should be swallowed whole with water, preferably with food to avoid stomach upset.

What are the possible side effects of TRENAXA MF?

Common side effects of TRENAXA MF include nausea, vomiting, diarrhea, stomach pain or discomfort, indigestion, heartburn, headache, dizziness, drowsiness, backache, and fatigue. Less common or severe side effects can include fits/seizures, blurred vision, ringing in the ears, constipation, bloating, and in rare cases, allergic reactions, difficulty breathing, or severe abdominal pain with blood in urine.

Is TRENAXA MF safe during pregnancy or breastfeeding?

TRENAXA MF is generally not recommended during pregnancy, especially in the last trimester, as it can lead to malformations in the growing fetus, delay labor, and increase the risk of bleeding in the mother and fetus. It is also advised not to breastfeed during treatment with TRENAXA MF, as its components can pass into breast milk and may harm the newborn. Always consult your doctor for advice if you are pregnant or breastfeeding.

Can TRENAXA MF be taken with other medications?

Caution is advised when taking TRENAXA MF with other medications. Medicines used to thin blood, such as Warfarin or Heparin, should be used with caution due to an increased risk of bleeding. Anti-platelet medicines like Aspirin or Clopidogrel, other painkillers (NSAIDs like ibuprofen or naproxen), and steroids can increase the risk of stomach or intestinal bleeding. Methotrexate and lithium should not be taken with this medicine due to potential toxicity. Oral contraceptive pills, when taken with Trenaxa MF, may increase the risk of blood clot formation. Antidiabetic medicines can lead to low blood glucose when taken with TRENAXA MF. Always inform your doctor about all medicines, herbal preparations, and supplements you are currently taking to avoid possible interactions.

What precautions should be taken when using TRENAXA MF?

Before taking TRENAXA MF, inform your doctor if you have any blood clotting disorders (e.g., deep vein thrombosis, pulmonary embolism), a history of stomach or intestinal bleeding due to painkillers, liver, kidney, or heart function problems, epilepsy or a history of convulsions, inflammatory bowel disease, or irregular menstrual bleeding. You should also be cautious if you are an elderly person, as there is an increased risk of side effects like ulcers and bleeding. Discontinue the treatment immediately if you experience visual disturbances. Avoid consuming alcohol with TRENAXA MF as it can increase the risk of stomach bleeding and drowsiness. This medicine can impair fertility, so it should not be taken if you are trying to conceive or undergoing fertility treatment.

What happens if a dose of TRENAXA MF is missed?

If you miss a dose of TRENAXA MF, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should TRENAXA MF be stored?

TRENAXA MF tablets should be stored at room temperature, ideally below 25°C or 30°C. Keep the medicine in its original container, tightly closed, and protect it from direct light and moisture. Ensure it is kept out of the reach of children and pets. Always check the expiry date and do not use the medicine beyond it.