Dapavel M 5/500 Mg Tablet (10 Tab)

DAPAVEL M 5/500 MG TABLET

DAPAVEL M 5/500 MG TABLET is a medication manufactured by Intas Pharmaceuticals Ltd., used for the management of Type 2 Diabetes Mellitus.

• Name:

  • Brand Name: DAPAVEL M 5/500 MG TABLET
  • Common Name: Dapagliflozin and Metformin Hydrochloride Tablets

• Composition:

  • Each tablet contains Dapagliflozin 5 mg and Metformin Hydrochloride 500 mg.

• Uses:

  • DAPAVEL M 5/500 MG TABLET is prescribed to improve blood sugar control in adults with Type 2 Diabetes Mellitus, especially when diet and exercise alone, or other medications, are insufficient.
  • It helps lower high blood glucose levels by increasing insulin sensitivity, decreasing glucose production in the liver, and promoting glucose excretion through urine.
  • It may also reduce the risk of heart failure and slow the progression of kidney disease in diabetic patients.

• Dosage and Administration:

  • This medicine should be taken orally with or without food, usually once daily in the morning, or as directed by a physician.
  • The dosage is individualized based on the patient's condition and response to treatment. Do not crush or chew the tablet.

• Side Effects:

  • Common: Nausea, vomiting, diarrhea, headache, dizziness, frequent urination, mild skin rash, itchy skin, stomach ache, loss of appetite, urinary tract infections, and genital infections (e.g., yeast infections).
  • Serious: Lactic acidosis (rare but serious, symptoms include vomiting, stomach pain, muscle cramps, difficulty breathing), and dehydration.

• Precautions:

  • Not recommended for Type 1 diabetes mellitus or severe kidney/liver disease.
  • Avoid alcohol consumption as it may increase the risk of lactic acidosis.
  • Caution is advised during pregnancy and breastfeeding; consult a doctor.
  • Inform your doctor about any history of heart disease, breathing problems, blood disorders, or low blood pressure.
  • Not recommended for individuals under 18 or generally for those aged 85 or older.

• Storage:

  • Store in a cool and dry place, ideally below 30°C.
  • Protect from direct sunlight and moisture.
  • Keep out of sight and reach of children.

DAPAVEL M 5/500 MG TABLET is a combination medication containing Dapagliflozin (5mg) and Metformin (500mg). It is used to manage type 2 diabetes mellitus in adults alongside diet and exercise. This medication helps control high blood sugar levels and can also reduce the risk of hospitalization for heart failure and the worsening of kidney disease in people with type 2 diabetes.

Here are some frequently asked questions about DAPAVEL M 5/500 MG TABLET:

What is DAPAVEL M 5/500 MG TABLET used for?

DAPAVEL M 5/500 MG TABLET is used to control high blood sugar in adults with type 2 diabetes mellitus, in conjunction with diet and exercise. It is also prescribed to reduce the risk of cardiovascular death, hospitalization for heart failure, and the progression of kidney disease in patients with type 2 diabetes and certain cardiovascular or kidney conditions.

How does DAPAVEL M 5/500 MG TABLET work?

This medicine combines two active ingredients:

• Dapagliflozin: This works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT-2). This action prevents the reabsorption of glucose back into the bloodstream, leading to the removal of excess sugar from the body through urine, thereby lowering blood sugar levels.
• Metformin: This works by decreasing the production of glucose in the liver, reducing its absorption from the intestines, and increasing the body's sensitivity to insulin. Together, these mechanisms provide better control of blood sugar.

What is the usual dosage for DAPAVEL M 5/500 MG TABLET?

The dosage is individualized by your doctor based on your current treatment and needs. Typically, it is taken once daily in the morning with food. The tablets should be swallowed whole and not crushed or chewed. Your doctor may adjust the dose as needed, but the maximum recommended daily dose is usually 10 mg dapagliflozin and 2000 mg metformin.

What are the possible side effects of DAPAVEL M 5/500 MG TABLET?

Common side effects can include headache, diarrhea, nausea, vomiting, runny nose, or a sore throat. More serious, though less common, side effects that require immediate medical attention include signs of a urinary tract infection (such as burning/painful urination, frequent urination, bloody urine), genital yeast infections, dehydration (increased thirst, dry mouth, dizziness), symptoms of lactic acidosis (unusual tiredness, severe drowsiness, muscle pain, fast/difficult breathing, stomach pain), and diabetic ketoacidosis (increased thirst/urination, fatigue, fruity breath odor).

Is it safe during pregnancy or breastfeeding?

DAPAVEL M 5/500 MG TABLET is generally not recommended during the second and third trimesters of pregnancy unless clearly needed, as there is limited information on its use and a theoretical risk to the unborn baby's developing kidneys. For breastfeeding mothers, it is not usually recommended because it is unknown how much dapagliflozin passes into breast milk and there's a theoretical risk to the infant's kidneys. Metformin does pass into breast milk in small amounts, but the risk of neonatal hypoglycemia is negligible. Your doctor will need to review your treatment and may suggest an alternative.

Can it be taken with other medications?

This medication can interact with other drugs. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking. For example, using it with diuretics may increase the risk of dehydration and low blood pressure. When taken with insulin or insulin secretagogues (like sulfonylureas), a lower dose of these medications may be required to minimize the risk of low blood sugar. Metformin's effects can be amplified by alcohol, increasing the risk of lactic acidosis. Certain drugs, including carbonic anhydrase inhibitors and those that decrease metformin clearance (e.g., cimetidine, ranolazine, vandetanib, dolutegravir), may increase the risk of lactic acidosis or metformin accumulation.

What precautions should be taken?

Before taking DAPAVEL M 5/500 MG TABLET, tell your doctor about your medical history, especially if you have kidney or liver disease, heart problems (including heart failure), breathing problems, a history of pancreatitis, or alcohol use. Dehydration can increase the risk of serious side effects like lactic acidosis and kidney problems, so it's important to drink plenty of fluids. You may need to temporarily stop this medication before surgery or imaging procedures that use iodinated contrast. Regular monitoring of kidney function, liver function, blood sugar, and vitamin B12 levels is usually required.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How should it be stored?

Store DAPAVEL M 5/500 MG TABLET at room temperature, away from light and moisture. Do not store it in the bathroom. Keep all medications out of the reach of children and pets.