Azulix Mv 1/0.2 Mg Tablet (10 Tab)

AZULIX MV 1/0.2 MG Tablet is an anti-diabetic medication manufactured by Torrent Pharmaceuticals Ltd., designed for the effective management of Type 2 Diabetes Mellitus in adults. This combination therapy aids in controlling blood sugar levels and reducing the risk of associated complications.

Name

• Brand Name: AZULIX MV 1/0.2 MG TABLET
• Common Name: Glimepiride + Metformin Hydrochloride + Voglibose (Fixed-dose combination)

Composition

Each tablet contains a combination of three active ingredients:

• Glimepiride (1 mg)
• Metformin Hydrochloride (500 mg)
• Voglibose (0.2 mg)

These ingredients work synergistically: Glimepiride stimulates insulin release from the pancreas, Metformin reduces glucose production by the liver and improves insulin sensitivity, and Voglibose slows down the absorption of carbohydrates from the intestines, thereby preventing post-meal blood sugar spikes.

Uses

AZULIX MV 1/0.2 MG Tablet is primarily used for:

• Treatment of Type 2 Diabetes Mellitus in adults, especially when diet, exercise, and single-agent or dual therapy are insufficient to adequately control blood sugar levels.
• Controlling high blood sugar levels.
• Reducing the risk of diabetes-related complications such as kidney damage (nephropathy), blindness (retinopathy), nerve damage (neuropathy), heart attack, and stroke.

Dosage and Administration

• AZULIX MV 1/0.2 MG Tablet should be taken orally as directed by a physician.
• It is generally recommended to take the tablet with or immediately before meals to minimize gastrointestinal side effects and ensure proper absorption.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• For optimal results, it is advisable to take the medicine at the same time each day.
• Do not stop taking the medicine or adjust the dose without consulting your doctor, as this can lead to an increase in blood sugar levels and potential complications.

Side Effects

Common side effects may include:

• Hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, hunger pangs, dry mouth and skin.
• Nausea, vomiting, diarrhea, and stomach pain.
• Headache.
• Changes in taste, loss of appetite, metallic taste.
• Upper respiratory tract infection.
• Flatulence.

Serious side effects, though rare, can include:

• Lactic acidosis, a rare but serious condition that requires immediate medical attention. Symptoms may include exhaustion, extreme fatigue, body weakness, diarrhea, and headache.
• Allergic reactions.

Precautions

• Allergies: Do not take if you are allergic to Glimepiride, Metformin, Voglibose, or other sulfonylureas/sulphonamides.
• Medical Conditions: Not recommended for patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe kidney or liver disease, acute heart conditions, or severe lung problems.
• Pregnancy and Breastfeeding: Contraindicated during pregnancy and breastfeeding as it may harm the fetus or nursing child.
• Alcohol Consumption: Avoid or limit alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
• Drug Interactions: Inform your doctor about all other medications you are taking, including antibacterials, cardiac glycosides, thyroid medications, NSAIDs, and blood thinners, as interactions can occur.
• Diet and Exercise: This medicine is part of a comprehensive treatment plan that must include a healthy diet, regular exercise, and weight reduction as advised by your doctor.
• Hypoglycemia Prevention: To prevent low blood sugar, do not skip meals and always carry a fast-acting source of glucose (e.g., sugary food or fruit juice).
• Monitoring: Regular monitoring of blood sugar levels, blood cell counts, and liver function may be advised by your doctor.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep out of sight and reach of children and pets.
• Typically stored below 25°C or below 30°C, protected from moisture and light.

AZULIX MV 1/0.2 MG TABLET, manufactured by Torrent Pharmaceuticals Ltd., is a combination medication used to manage type 2 diabetes mellitus. It contains three active ingredients: Glimepiride, Metformin, and Voglibose, which work together to help control blood sugar levels.

What is AZULIX MV 1/0.2 MG TABLET used for?

AZULIX MV 1/0.2 MG TABLET is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and single or dual anti-diabetic medications are not enough to adequately control blood sugar levels. This medicine helps to control high blood sugar and can assist in preventing serious complications of diabetes, such as kidney damage, vision problems, nerve issues, and limb loss.

How does AZULIX MV 1/0.2 MG TABLET work?

AZULIX MV 1/0.2 MG TABLET combines three active ingredients, each with a distinct mechanism of action to lower blood sugar:

• Glimepiride: Stimulates the pancreas to release more insulin.
• Metformin: Decreases glucose production by the liver, reduces glucose absorption from the intestines, and improves the body's sensitivity to insulin.
• Voglibose: Slows down the digestion and absorption of complex carbohydrates in the intestine, thereby reducing the rise in blood glucose levels after meals. Together, these actions help to effectively control blood sugar levels.

What is the usual dosage for AZULIX MV 1/0.2 MG TABLET?

This medicine should be taken orally as directed by your doctor. It is typically taken with or after a meal and swallowed whole with a glass of water, without crushing or chewing. For optimal results, it is recommended to take it at a fixed time each day. Your doctor will determine the appropriate dose, which may be adjusted based on your blood sugar levels and individual response. Do not exceed the prescribed dose or stop taking the medicine abruptly without consulting your doctor.

What are the possible side effects of AZULIX MV 1/0.2 MG TABLET?

Common side effects can include low blood glucose levels (hypoglycemia), changes in taste, nausea, diarrhea, stomach pain, headache, abdominal pain, loss of appetite, metallic taste, upper respiratory tract infection, dizziness, flatulence, and occasionally weight gain. More serious but rare side effects include lactic acidosis (symptoms like exhaustion, extreme fatigue, weakness, diarrhea, and headache) and severe hypoglycemia.

Is AZULIX MV 1/0.2 MG TABLET safe during pregnancy or breastfeeding?

No, AZULIX MV 1/0.2 MG TABLET is generally not recommended and is contraindicated during pregnancy as it may cause harm to the developing fetus. Similarly, it is not recommended during breastfeeding because the medicine may pass into breast milk and harm the nursing infant. Your doctor may suggest alternative treatments, such as insulin, or advise stopping breastfeeding.

Can AZULIX MV 1/0.2 MG TABLET be taken with other medications?

AZULIX MV 1/0.2 MG TABLET can interact with other medications. It is crucial to inform your doctor about all medicines, including prescription, over-the-counter, herbal remedies, and dietary supplements you are taking. Caution is particularly needed when taken with other antidiabetic medicines or insulin, as this combination can lead to very low blood sugar levels (hypoglycemia). Interactions have been noted with certain antibacterials, antifungals, oral contraceptives, water pills, thyroid medications, blood thinners, NSAIDs, and cardiac glycosides, among others. For example, glimepiride should be taken at least 4 hours before colesevelam.

What precautions should be taken while using AZULIX MV 1/0.2 MG TABLET?

Avoid this medicine if you have known allergies to its components, type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, metabolic acidosis (like lactic acidosis), severe infections, certain heart conditions (e.g., heart failure), stomach or intestinal obstruction, or acute alcohol intoxication/alcoholism. Regular monitoring of blood sugar, liver function, and kidney function is recommended. Avoid alcohol, as it increases the risk of low blood sugar and lactic acidosis. Always carry a source of sugar (like juice or chocolate) for immediate relief if you experience symptoms of hypoglycemia. Inform your doctor if you are scheduled for a CT scan or MRI with contrast media, as the medicine may need to be stopped a few days prior. Avoid prolonged fasting and ensure you do not miss meals. This medicine may also cause a decrease in vitamin B12 levels with long-term use, so monitoring is advised.

What happens if a dose is missed?

If you miss a dose of AZULIX MV 1/0.2 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one. Missing several doses or not adhering to dietary and lifestyle recommendations can increase the risk of high blood sugar.

How should AZULIX MV 1/0.2 MG TABLET be stored?

Store AZULIX MV 1/0.2 MG TABLET below 25°C or 30°C, in the packet or container it came in, tightly closed. Keep the medicine out of the reach and sight of children. Properly dispose of any unused medicine.