Inapure Er 10 Mg Tablet (10 Tab)

INAPURE ER 10 MG TABLET

INAPURE ER 10 MG TABLET is a medication primarily used for the management of certain chronic heart conditions. It is manufactured by SUN PHARMA LABORATORIES LTD.

• Name: Inapure ER 10 mg Tablet.
• Composition: Each tablet contains Ivabradine 10 mg (sustained release).
• Uses:
  • Management of stable angina pectoris (heart-related chest pain) in adults. It helps reduce the frequency of angina attacks and improves exercise tolerance.
  • Management of chronic heart failure with systolic dysfunction in adults, especially when the heart rate is ≥ 75 bpm, in conjunction with standard therapy. It helps lower the risk of hospitalization due to worsening heart failure. Ivabradine works by specifically slowing the heart rate, thereby decreasing the heart's demand for oxygen and improving blood flow to the heart muscle.
• Dosage and Administration:
  • The typical starting dosage for adults is 5 mg twice daily, taken with meals.
  • Depending on the patient's response, the dosage may be increased to a maximum of 7.5 mg twice daily.
  • Tablets should be swallowed whole; do not break, crush, or chew.
  • It is generally taken orally twice daily with meals.
• Side Effects:
  • Common: Temporary visual disturbances (luminous phenomena or enhanced brightness), slow heart rate (bradycardia), high blood pressure, dizziness, blurred vision, ECG changes, atrial fibrillation, headache. Other reported side effects include nausea, constipation, diarrhea, and abdominal pain.
  • Serious: Fainting and significant alterations in heartbeat warrant immediate medical attention. Increased risk of irregular or rapid heartbeat (atrial fibrillation or heart rhythm problems) and slower than normal heart rate (bradycardia) can be serious.
• Precautions:
  • Contraindicated in individuals with severe liver disease, a low resting heart rate, certain heart rhythm disorders, very low blood pressure, or heart failure that has recently worsened.
  • Not recommended during pregnancy, when trying to conceive, or while breastfeeding.
  • Exercise caution while driving or operating machinery until familiar with the medication's effects, as it may cause dizziness and visual disturbances.
  • Regular monitoring of heart rate and blood pressure is crucial.
  • Inform your doctor about all other medications, especially antifungals (e.g., ketoconazole, itraconazole), certain calcium channel blockers (e.g., verapamil, diltiazem), and rifampicin, as interactions can occur.
• Storage: Store at room temperature, away from heat and moisture, and below 30°C. Keep out of reach of children.

What is INAPURE ER 10 MG TABLET used for?

INAPURE ER 10 MG TABLET is primarily used to manage symptoms of stable angina pectoris, which is heart-related chest pain, and chronic heart failure in adults. It is particularly recommended for patients with stable angina whose heart rate is equal to or above 70 beats per minute and who cannot tolerate beta-blockers, or for those with chronic heart failure whose heart rate is equal to or above 75 beats per minute.

How does INAPURE ER 10 MG TABLET work?

The active ingredient in INAPURE ER 10 MG TABLET is Ivabradine. It belongs to a class of medications called hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. Ivabradine works by specifically slowing the heart rate by a few beats per minute, which reduces the heart's oxygen demand and its workload. This action helps to alleviate chest discomfort in angina and improves the heart's efficiency in pumping blood throughout the body, thereby reducing the likelihood of hospitalization in individuals with heart failure.

What is the usual dosage of INAPURE ER 10 MG TABLET?

For adults, the typical starting dosage of INAPURE ER 10 MG TABLET is 5 mg taken twice daily with meals. Depending on the patient's response and heart rate, the doctor may adjust the dosage, with a maximum recommended dose of 7.5 mg twice daily. It is crucial to adhere to the prescribed dosage and not to alter it without consulting a healthcare professional. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

What are the possible side effects of INAPURE ER 10 MG TABLET?

Common side effects of INAPURE ER 10 MG TABLET include a slow heart rate (bradycardia), temporary visual disturbances such as enhanced brightness or luminous phenomena (phosphenes), high blood pressure, atrial fibrillation, dizziness, blurred vision, and ECG changes. Other reported side effects may include headache, nausea, abdominal pain, diarrhea, and a sudden spinning sensation (vertigo). Serious side effects like fainting or significant alterations in heartbeat warrant immediate medical attention.

Is INAPURE ER 10 MG TABLET safe during pregnancy or breastfeeding?

INAPURE ER 10 MG TABLET is generally not recommended during pregnancy and is considered unsafe, as studies have shown potential harm to the unborn baby. Women who are capable of becoming pregnant should use effective birth control measures during treatment. It is also unsafe during breastfeeding, as the medicine may be excreted in human breast milk and could cause toxicity to the baby. Women on this medication should stop breastfeeding and consider alternative feeding methods for their child.

Can INAPURE ER 10 MG TABLET be taken with other medications?

INAPURE ER 10 MG TABLET can interact with certain medications. It is not recommended for use with strong CYP3A4 inhibitors, such as antifungals (e.g., ketoconazole, itraconazole), antibiotics (e.g., clarithromycin), medicines for HIV infection (e.g., ritonavir, nelfinavir), and certain antidepressants (e.g., nefazodone). Concomitant use with heart rate-reducing calcium channel blockers like verapamil or diltiazem is also not advised. Patients should inform their doctor about all prescription, over-the-counter medications, herbal products, or supplements they are taking to avoid potential interactions.

What precautions should be taken while using INAPURE ER 10 MG TABLET?

Several precautions should be taken when using INAPURE ER 10 MG TABLET. It is contraindicated in individuals with severe liver disease, a low resting heart rate, certain heart rhythm disorders (like sick sinus syndrome or 3rd-degree atrioventricular block), or very low blood pressure. Caution is advised for patients with kidney problems, chronic retinal diseases, or those who have recently had a stroke. Regular monitoring of heart rate and blood pressure is recommended. Patients should avoid driving or operating machinery if they experience dizziness or visual disturbances. Grapefruit and grapefruit juice should be avoided as they may interfere with the medicine's effectiveness. Alcohol consumption should also be limited or avoided due to increased risk of side effects like dizziness and low blood pressure.

What happens if a dose of INAPURE ER 10 MG TABLET is missed?

If a dose of INAPURE ER 10 MG TABLET is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. It is important not to take a double dose to compensate for a missed one.

How should INAPURE ER 10 MG TABLET be stored?

INAPURE ER 10 MG TABLET should be stored at room temperature, protected from moisture and heat. It should be kept out of the reach and sight of children and pets. Storage in cool places, ideally between 10ºC to 25ºC or below 30ºC, is recommended.