Arnoza 100 Tab

ARNOZA 100 Tablet

ARNOZA 100 Tablet, manufactured by Torrent Pharmaceuticals Ltd, is a medication primarily used in the management of chronic heart failure in adults.

• Composition Each ARNOZA 100 Tablet contains a fixed-dose combination of Sacubitril (49 mg) and Valsartan (51 mg). This combination classifies it as an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril works by inhibiting neprilysin, increasing beneficial peptides that relax blood vessels, while Valsartan, an angiotensin receptor blocker (ARB), blocks hormones that constrict blood vessels, thereby lowering blood pressure and reducing fluid retention.

• Uses ARNOZA 100 Tablet is prescribed for the treatment of heart failure, a condition where the heart struggles to pump blood efficiently. It helps to reduce the risk of hospitalization and cardiovascular death in adult patients with chronic heart failure by improving the heart's pumping ability and reducing strain on the cardiovascular system. It can also help manage symptoms like shortness of breath, fatigue, and swelling in the feet and ankles.

• Dosage and Administration The dosage and frequency are determined by a healthcare professional based on the patient's condition and response to the medicine. It is recommended to take the tablet whole with a glass of water, with or without food, at the same time each day for maximum benefit. Do not crush, chew, or split the tablets.

• Side Effects Common side effects may include low blood pressure (hypotension), high potassium levels in the blood (hyperkalemia), cough, dizziness, and kidney problems (impaired renal function). More serious but less common side effects can include angioedema (swelling of the face, lips, tongue, and throat).

• Precautions Before taking ARNOZA 100, inform your doctor about any kidney or liver diseases, or if you are taking other medications for blood pressure or heart conditions. It is contraindicated in pregnancy, especially after the first three months, and is not recommended for breastfeeding women. Alcohol consumption should be avoided as it can increase dizziness. Caution is advised when used with ACE inhibitors (not within 36 hours), aliskiren (especially in diabetic or renally impaired patients), lithium, potassium-sparing diuretics, potassium supplements, and NSAIDs due to potential interactions. Patients should get up slowly from sitting or lying positions to reduce the risk of dizziness from low blood pressure.

Frequently Asked Questions about ARNOZA 100 TAB

What is ARNOZA 100 TAB used for?

ARNOZA 100 TAB is primarily used to treat heart failure in adults and children over one year of age. It helps to reduce the risk of hospitalization and death in adults with chronic heart failure. It can also be used for hypertension management and cardiovascular protection by lowering blood pressure, which helps to reduce the risk of heart attacks and strokes.

How does ARNOZA 100 TAB work?

ARNOZA 100 TAB is a combination of two medicines: Sacubitril (49mg) and Valsartan (51mg). Valsartan, an angiotensin receptor blocker (ARB), works by blocking the effect of angiotensin II receptors, which constrict blood vessels. Sacubitril, a neprilysin inhibitor, works by relaxing and widening the blood vessels and increasing the excretion of sodium through urine. Together, these actions make it easier for the heart to pump blood to all parts of the body, improving heart function and reducing strain on the heart.

What is the usual dosage for ARNOZA 100 TAB?

The dosage and duration of treatment are determined by your doctor based on your age, body weight, disease condition, and response to the medicine. It is crucial to take ARNOZA 100 TAB exactly as prescribed by your physician and not to exceed the recommended dose. The tablets should be swallowed whole with a glass of water and not crushed or chewed.

What are the possible side effects of ARNOZA 100 TAB?

Common side effects of ARNOZA 100 TAB may include dizziness, light-headedness (low blood pressure), cough, headache, tiredness, weakness, nausea, diarrhea, and increased potassium levels in the blood (hyperkalemia). Less common but serious side effects can include angioedema (swelling of the face, lips, tongue, or throat, which may cause breathing difficulties) and kidney problems. If you experience any severe or persistent side effects, you should consult your doctor immediately.

Is ARNOZA 100 TAB safe during pregnancy or breastfeeding?

No, ARNOZA 100 TAB is not recommended for use during pregnancy, especially after the first three months, as it may cause serious harm or endanger the life of the baby. It is also not recommended for use during breastfeeding. If you are pregnant or breastfeeding, or plan to become pregnant, consult your doctor for suitable alternatives.

Can ARNOZA 100 TAB be taken with other medications?

ARNOZA 100 TAB can interact with several other medications. It should not be taken with ACE inhibitors (such as enalapril, lisinopril, or ramipril) or within 36 hours before or after taking an ACE inhibitor, as this can increase the risk of side effects like angioedema. Concomitant use with aliskiren (a blood pressure-lowering medicine), especially in patients with diabetes or impaired kidney function, is also contraindicated. Other interactions can occur with potassium supplements, potassium-sparing diuretics, certain painkillers (NSAIDs), and lithium. Always inform your doctor about all medications, herbal preparations, and supplements you are currently taking to avoid potential drug interactions.

What precautions should be taken with ARNOZA 100 TAB?

Before taking ARNOZA 100 TAB, inform your doctor if you have kidney or liver diseases, a history of angioedema, diabetes, low blood pressure, or are experiencing dehydration, vomiting, or diarrhea. This medicine may cause dizziness, so avoid driving or operating heavy machinery if you feel dizzy. Rise slowly from sitting or lying positions to reduce the risk of dizziness from low blood pressure. Regular monitoring of blood pressure, kidney function, and potassium levels may be advised during treatment.

What happens if a dose of ARNOZA 100 TAB is missed?

If you miss a dose of ARNOZA 100 TAB, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should ARNOZA 100 TAB be stored?

ARNOZA 100 TAB should be stored in a cool and dry place, away from direct sunlight and moisture, ideally below 30°C. Keep it out of the sight and reach of children.