Istamet Empa 10/100/1000mg Tab

ISTAMET EMPA 10/100/1000MG Tablet

Name:

• Brand Name: ISTAMET EMPA 10/100/1000MG Tablet (also available as ER - Extended Release formulation)
• Common Name: Empagliflozin, Metformin, and Sitagliptin combination tablet.

Composition: Each tablet contains three active ingredients:

• Empagliflozin 10mg
• Sitagliptin 100mg
• Metformin 1000mg

Uses: ISTAMET EMPA 10/100/1000MG Tablet is prescribed for the management of type 2 diabetes mellitus in adults. It is typically used when diet and exercise alone are insufficient to control blood sugar levels, or when metformin monotherapy is inadequately controlled. The medicine helps maintain healthy blood sugar levels and may reduce the risk of long-term diabetes-related complications such as heart disease, kidney problems, nerve damage, and eyesight issues.

Dosage and Administration: This medicine should be taken orally with meals, as advised by your doctor, usually once or twice daily. Regular dosing at the same time each day helps maintain steady blood sugar control. The tablets should be swallowed whole and not chewed, crushed, or broken. Do not skip doses or stop treatment without medical advice.

Side Effects:

• Common Side Effects: Increased urination, nausea, diarrhoea, stomach upset, skin rash, headache, increased thirst, constipation, and urinary tract infection.
• Serious Side Effects: Severe stomach pain, tiredness or muscle pain (potentially lactic acidosis), severe allergic reactions, pancreatitis, or very low blood sugar (hypoglycemia), especially when used with other diabetes medications. Dehydration and ketoacidosis can also occur.

Precautions: ISTAMET EMPA is not recommended for individuals with type 1 diabetes, severe kidney impairment, or liver disease. It is generally not advised during pregnancy or breastfeeding, and caution is needed in older adults and those with heart problems. Alcohol consumption should be avoided as it may worsen side effects and increase the risk of lactic acidosis. Blood sugar levels can fluctuate during illness, stress, or surgery, requiring potential dose adjustments. Patients should monitor blood sugar, kidney function, and hydration status regularly.

Storage: Store in a cool and dry place, away from direct sunlight, typically between 10ºC to 25ºC or below 30ºC. Keep the medicine out of the sight and reach of children.

ISTAMET EMPA 10/100/1000MG Tablet: Frequently Asked Questions

ISTAMET EMPA 10/100/1000MG Tablet is a combination medication used to manage type 2 diabetes mellitus in adults. It contains three active ingredients: Empagliflozin (10mg), Sitagliptin (100mg), and Metformin (1000mg).

What is ISTAMET EMPA used for?

ISTAMET EMPA 10/100/1000MG Tablet is primarily used to manage type 2 diabetes mellitus in adults, especially when diet and exercise alone are insufficient for blood sugar control, or when Metformin monotherapy is inadequately controlling the condition. This combination therapy improves glycemic control by enhancing insulin action and promoting renal glucose excretion. It may also help reduce the risk of long-term diabetes-related complications, including cardiovascular events, kidney problems, and nerve damage.

How does ISTAMET EMPA work?

This medicine works through three complementary actions from its active ingredients:

• Empagliflozin (an SGLT2 inhibitor) works on the kidneys to remove excess sugar from the body through urine.
• Metformin (a biguanide) reduces sugar production in the liver, improves how the body uses insulin, and decreases sugar absorption from food.
• Sitagliptin (a DPP-4 inhibitor) increases natural hormones (incretins) that stimulate insulin release after meals and reduce excess sugar release from the liver. Together, these actions provide comprehensive blood sugar control.

What is the usual dosage of ISTAMET EMPA?

The dosage of ISTAMET EMPA 10/100/1000MG Tablet should be individualized based on the patient's current antidiabetic regimen, clinical response, and tolerability, as determined by a doctor. For the triple combination, general dosing information for the individual components when used in combination suggests that the medication is taken with food. It is crucial to follow your doctor's instructions carefully.

What are the possible side effects of ISTAMET EMPA?

Common side effects can include increased urination, urinary tract infections, genital yeast infections, nausea, diarrhea, stomach upset, headache, and metallic taste. Less common but more serious side effects can include ketoacidosis, dehydration, lactic acidosis (especially with Metformin), kidney problems, and severe allergic reactions. If you experience symptoms like extreme thirst, nausea, vomiting, rapid breathing (possible ketoacidosis), or severe abdominal pain, seek immediate medical attention.

Is ISTAMET EMPA safe during pregnancy or breastfeeding?

ISTAMET EMPA 10/100/1000MG Tablet is generally not recommended during pregnancy or breastfeeding due to limited information on its safety and effectiveness in these situations. Empagliflozin is not recommended during pregnancy, and sitagliptin is also not usually recommended while breastfeeding. Metformin is considered a safer option during pregnancy and breastfeeding compared to other oral antidiabetic drugs. If you are pregnant, planning a pregnancy, or breastfeeding, you should discuss your treatment with your doctor, who may suggest alternative medications.

Can ISTAMET EMPA be taken with other medications?

Yes, ISTAMET EMPA can interact with other medications. It's important to inform your doctor about all prescription and nonprescription medications, vitamins, and herbal products you are taking. Combining it with insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycemia), and your doctor may need to adjust doses to reduce this risk. Certain medical conditions and drugs like carbonic anhydrase inhibitors can increase the risk of lactic acidosis.

What precautions should be taken while using ISTAMET EMPA?

Several precautions should be taken:

• Kidney and Liver Function: This medicine is not recommended for severe kidney problems or liver disease. Renal function should be assessed before and periodically during treatment.
• Dehydration: Empagliflozin can cause dehydration; adequate fluid intake is important.
• Alcohol: Avoid alcohol intake as it may increase the risk of lactic acidosis and low blood sugar.
• Illness/Stress: Illness, infection, or unusual stress can affect blood sugar levels, and your doctor may need to adjust your medication.
• Ketoacidosis: Be aware of the symptoms of ketoacidosis (e.g., nausea, vomiting, abdominal pain, tiredness, labored breathing) and seek immediate medical care if they occur.
• Hypoglycemia: Monitor blood sugar levels regularly, especially when combined with other diabetes medications, and be aware of the symptoms of low blood sugar.
• Hygiene: Maintain good personal hygiene to reduce the risk of urinary or genital infections.

What happens if a dose is missed?

If you miss a dose of ISTAMET EMPA, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Regularly missing doses can lead to increased blood sugar levels and potential complications.

How should ISTAMET EMPA be stored?

Store ISTAMET EMPA tablets in a closed container at room temperature, away from heat, moisture, and direct light. Do not store above 25°C (77°F). Keep it out of reach of children and do not use outdated medicine.