Fosfocin Sachet 8 Gm (powder)

FOSFOCIN SACHET 8 GM (POWDER)

FOSFOCIN SACHET 8 GM is an antibiotic medication manufactured by Aristo Pharmaceuticals Pvt Ltd.

• Name:

  • Brand Name: FOSFOCIN SACHET 8 GM
  • Common Name: Fosfomycin (as Fosfomycin Trometamol)

• Composition:

  • Active Ingredient: Fosfomycin 8 gm

• Uses: FOSFOCIN SACHET is primarily prescribed for the following conditions:

  • Treatment of acute uncomplicated lower urinary tract infections (UTIs) and bladder infections (acute cystitis) in women and female adolescents caused by susceptible bacteria like Escherichia coli and Enterococcus faecalis.
  • Antibiotic prophylaxis for transrectal prostate biopsy in men.

• Dosage and Administration:

  • Typical Dosage: For adults (women 18 years of age and older) with uncomplicated lower UTIs, the recommended dosage is a single sachet (8 gm).
  • Preparation: The entire contents of one sachet should be dissolved in 3 to 4 ounces (approximately half a glass) of water. Do not use hot water.
  • Administration: Drink the entire mixture immediately after preparation. Do not swallow the powder in its dry form.
  • Timing: It is preferable to take FOSFOCIN SACHET on an empty stomach, either one hour before or at least two hours after meals, ideally at bedtime after emptying the bladder.
  • Pediatric Use: Not recommended for children under 12 years of age.

• Side Effects:

  • Common Side Effects: Headache, dizziness, indigestion, nausea, diarrhea, and vulvovaginitis (swelling or infection of the vulva and vagina).
  • Serious Side Effects (Rare): Severe abdominal cramps, bloody stools, severe diarrhea (which may indicate pseudomembranous colitis), and allergic reactions such as anaphylactic shock (rash, itching, hives, shortness of breath, wheezing) or angioedema (swelling of the face, lips, tongue, or throat).

• Precautions:

  • Allergies: Inform your doctor if you are allergic to fosfomycin or any other ingredients in the sachet.
  • Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding unless deemed necessary by a doctor, as components may pass into breast milk.
  • Kidney Impairment: Contraindicated in patients with severe kidney disease or those undergoing hemodialysis. Use with caution in patients with other kidney problems.
  • Diarrhea: Use with caution if you have a history of diarrhea caused by other antibiotics. Severe diarrhea can occur even after stopping the medication.
  • Drug Interactions: Concomitant use with metoclopramide may decrease the blood concentration of fosfomycin. Inform your doctor about all other medicines and supplements you are taking.
  • Alcohol and Caffeine: Avoid alcohol and caffeinated beverages, as they may irritate the bladder or increase dizziness.
  • Driving: FOSFOCIN SACHET may cause dizziness or sleepiness; avoid driving or operating heavy machinery until you know how it affects you.
  • Hydration: Drink plenty of fluids daily while taking this medicine.

• Storage:

  • Store in a cool and dry place, away from direct sunlight, heat, and moisture.
  • Keep out of the reach of children.
  • Store below 25°C or at 10-25°C, or below 30°C. Do not freeze.

FOSFOCIN SACHET 8 GM is an antibiotic primarily used to treat bacterial infections. Below are some frequently asked questions about this medication.

What is FOSFOCIN SACHET 8 GM used for?

FOSFOCIN SACHET 8 GM, which contains Fosfomycin, is primarily used to treat uncomplicated bacterial infections of the bladder (acute cystitis) in women and female adolescents. It is also used as antibiotic prophylaxis for transrectal prostate biopsy in men. This medicine works by killing or preventing the growth of bacteria responsible for these infections.

How does FOSFOCIN SACHET 8 GM work?

FOSFOCIN SACHET 8 GM works by inhibiting the synthesis of the bacterial cell wall, a crucial protective covering necessary for bacterial survival. Specifically, Fosfomycin inactivates an enzyme called UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), which is involved in the very first step of peptidoglycan (bacterial cell wall component) biosynthesis. It also helps by reducing the ability of bacteria to adhere to the cells lining the urinary tract.

What is the usual dosage of FOSFOCIN SACHET 8 GM?

For the treatment of uncomplicated bladder infections in adults and teenagers 13 to 17 years of age, the usual dosage is a single 3-gram packet of Fosfomycin dissolved in water, taken once. The FOSFOCIN SACHET 8 GM (which contains 8gm of active ingredient) might be used in more severe or complicated cases, or for other indications as determined by your doctor, where daily adult doses can range from 12 to 24 grams, sometimes in divided doses, or as a single loading dose followed by continuous infusion for systemic infections. It is crucial to follow your doctor's specific instructions for your condition.

How should I take FOSFOCIN SACHET 8 GM?

The entire contents of the sachet should be dissolved in 3 to 4 ounces (about ½ cup) of cold water immediately before drinking. Do not use hot water and do not swallow the powder in its dry form. It can be taken with or without food, but some sources suggest taking it on an empty stomach, preferably before bedtime and after emptying the bladder, to allow the medication to stay in the bladder longer.

What are the possible side effects of FOSFOCIN SACHET 8 GM?

Common side effects include headache, dizziness, nausea, upset stomach, indigestion, diarrhea, and vaginal yeast infections or itching. More severe, though rare, side effects can include severe diarrhea (watery or bloody), which may occur even months after taking the medicine, allergic reactions (rash, hives, swelling of the face/lips/tongue/throat, difficulty breathing), fever, and new or worsening bladder symptoms. If you experience any severe or persistent side effects, contact your doctor immediately.

Is FOSFOCIN SACHET 8 GM safe during pregnancy or breastfeeding?

Pregnancy: While studies have not found fosfomycin to be harmful during pregnancy, its use is generally not recommended unless clearly needed and the potential benefits outweigh the risks. It has been considered safe to use in all trimesters for uncomplicated UTIs by some guidelines. Always consult your doctor if you are pregnant or plan to become pregnant.

Breastfeeding: Fosfomycin is excreted in human milk in low levels. A single dose when breastfeeding appears to be safe, and it is generally considered unlikely to cause adverse effects in breastfed infants, especially if the infant is older than 2 months. However, it is still advisable to consult your doctor before taking this medication while breastfeeding.

Can FOSFOCIN SACHET 8 GM be taken with other medications?

FOSFOCIN SACHET 8 GM can interact with certain medications. It is important to tell your doctor and pharmacist about all prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Specifically, metoclopramide (a medicine that increases the movement of food through the stomach and intestines) may decrease the absorption of fosfomycin, potentially reducing its effectiveness. Certain vaccines, like BCG vaccine live, cholera vaccine, and typhoid vaccine live, may have their efficacy decreased when combined with fosfomycin. Sodium bicarbonate, Ural®, or Citravescent® can also reduce the efficacy of fosfomycin and should be avoided on the same day or within 2 days after taking fosfomycin.

What precautions should be taken?

Inform your doctor if you have any allergies to fosfomycin or other drugs, or if you have a history of asthma, liver disease, or severe kidney problems, especially if you are on hemodialysis. Diarrhea can occur with this medicine, and in some cases, it can be severe and appear even months after treatment. Do not take anti-diarrhea medicine without consulting your doctor first. If your symptoms do not improve within 2 to 3 days or worsen, contact your doctor. Since fosfomycin can cause dizziness, avoid driving or operating heavy machinery if you experience this side effect. Drink plenty of fluids to help flush out the infection.

What happens if a dose is missed?

FOSFOCIN SACHET 8 GM is typically a single-dose treatment for uncomplicated UTIs. Therefore, the concept of a "missed dose" does not usually apply. However, if you are prescribed a multi-dose regimen for a specific condition and miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should it be stored?

Keep FOSFOCIN SACHET 8 GM in its original package, tightly closed, at room temperature, away from moisture and heat. Do not store it in the bathroom. Ensure it is kept out of reach of children and pets. Dispose of any unused or expired medication properly, preferably through a medicine take-back program.