Pasivon 20 Mg

PASIVON 20 MG by CIPLA

Pasivon 20 mg is a medication manufactured by Cipla Ltd., primarily used to treat various gastrointestinal disorders.

• Composition The active ingredient in Pasivon 20 mg is Vonoprazan 20 mg. Vonoprazan is a potassium-competitive acid blocker (PCAB) that works by inhibiting the H+, K+-ATPase enzyme in the stomach's parietal cells, thereby reducing the amount of acid produced in the stomach. This mechanism offers faster and more consistent control of gastric pH compared to some other acid-reducing medications.

• Uses Pasivon 20 mg is prescribed for several conditions related to excessive stomach acid:

  • Reflux Esophagitis: Helps heal damage to the esophagus caused by stomach acid and reduces symptoms like heartburn and acid reflux.
  • Gastric Ulcers and Duodenal Ulcers: Aids in healing sores in the lining of the stomach or intestine and helps prevent their recurrence, especially during the use of low-dose aspirin or NSAIDs.
  • Helicobacter pylori (H. pylori) Infection: Used in combination with antibiotics to eliminate H. pylori bacteria, which can cause stomach ulcers, and helps prevent recurrence.
  • Gastroesophageal Reflux Disease (GERD): Decreases acid production to alleviate symptoms like heartburn and acid regurgitation.

• Dosage and Administration Pasivon 20 mg tablets are typically taken orally, usually once daily, or as prescribed by a doctor. It can be taken with or without food, but should be swallowed whole with a glass of water without breaking, crushing, or chewing. For maximum benefits, it is advisable to take it at the same time each day.

• Side Effects

  • Common Side Effects: Diarrhoea, bloating, stomach pain, nausea, indigestion, high blood pressure, and urinary tract infection (UTI). These are usually temporary.
  • Serious Side Effects: Kidney problems, Clostridioides difficile-associated diarrhoea, bone fractures, severe skin reactions, low vitamin B12 levels, low magnesium levels, or fundic gland polyps (stomach growths).

• Precautions Before taking Pasivon 20 mg, inform your doctor if you have any allergies to its ingredients or other medications. Caution is advised for patients with kidney or liver disorders, osteopenia, osteoporosis, or low levels of calcium, magnesium, or potassium in the blood. Pregnant or breastfeeding women should consult their doctor before use. Alcohol consumption and smoking should be avoided as they can worsen symptoms and interfere with the medication's effectiveness. Pasivon 20 mg may interact with certain medications, including Rilpivirine-containing compounds, iron salts, Erlotinib, Dasatinib, Nilotinib, Mycophenolate mofetil, and Ketoconazole/Itraconazole, potentially reducing their effectiveness.

• Storage Pasivon 20 mg tablets should be stored in a cool and dry place, preferably below 30°C, away from direct sunlight, and out of the sight and reach of children and pets.

Here are some frequently asked questions about PASIVON 20 MG, a medication manufactured by Cipla, containing Vonoprazan:

What is PASIVON 20 MG used for?

PASIVON 20 MG is primarily used to treat various gastrointestinal disorders related to excess stomach acid. These include reflux esophagitis, gastric ulcers, and duodenal ulcers. It is also prescribed to prevent the recurrence of gastric or duodenal ulcers, particularly when using low-dose aspirin or NSAIDs. Additionally, it is used in combination with antibiotics to treat Helicobacter pylori (H. pylori) infection, which can cause stomach ulcers.

How does PASIVON 20 MG work?

PASIVON 20 MG contains Vonoprazan, which belongs to a class of medications called potassium-competitive acid blockers (PCABs). It works by inhibiting the H+, K+-ATPase enzyme found in the parietal cells of the stomach lining. This enzyme is responsible for pumping acid into the stomach. By blocking this enzyme, Vonoprazan effectively reduces the amount of acid produced in the stomach, helping to heal ulcers and alleviate acid-related symptoms. It offers advantages such as a faster onset of action and sustained acid suppression compared to traditional proton pump inhibitors (PPIs), as its effects are not influenced by meals.

What is the usual dosage for PASIVON 20 MG?

The typical adult dosage for PASIVON 20 MG is often 20 mg once daily. However, for the treatment of H. pylori infection, it may be prescribed at 20 mg twice daily, usually in combination with antibiotics like clarithromycin and amoxicillin, for a duration of 14 days. It can be taken with or without food. Always follow your doctor's specific instructions regarding dosage and duration.

What are the possible side effects of PASIVON 20 MG?

Common side effects of PASIVON 20 MG may include diarrhea, bloating, stomach pain, nausea, indigestion, high blood pressure, and urinary tract infections. More serious, but less common, side effects can include kidney problems, Clostridioides difficile-associated diarrhea, bone fractures, severe skin reactions, and low levels of vitamin B12 or magnesium. If you experience persistent or severe side effects, consult your doctor.

Is PASIVON 20 MG safe during pregnancy or breastfeeding?

Information regarding the use of Vonoprazan (the active ingredient in PASIVON 20 MG) during pregnancy and breastfeeding is limited or not well-established. It is not known if Vonoprazan passes into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to consult your doctor. Your healthcare provider will assess the potential benefits against any potential risks before prescribing this medication.

Can PASIVON 20 MG be taken with other medications?

PASIVON 20 MG can interact with certain medications. It may reduce the effectiveness of some HIV/AIDS medications like Rilpivirine, Nelfinavir, and Atazanavir. It can also reduce the effect of medicines that require stomach acid for proper absorption, such as iron salts, Erlotinib, Dasatinib, Nilotinib, Mycophenolate mofetil, and Ketoconazole/Itraconazole. Conversely, PASIVON 20 MG is often prescribed with antibiotics (e.g., amoxicillin and clarithromycin) for the treatment of H. pylori infection. Always inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using PASIVON 20 MG?

Before starting PASIVON 20 MG, inform your doctor if you have any allergies to its ingredients or if you have a history of kidney or liver disorders, osteopenia (bone mass loss), osteoporosis, or low levels of calcium, magnesium, or potassium in your blood. Avoid alcohol consumption as it can irritate the stomach lining and worsen acid production. Do not exceed the prescribed dose or stop taking the medication abruptly without consulting your doctor, as this may reduce its effectiveness or lead to a recurrence of symptoms. The safety and effectiveness in children have not been established.

What happens if a dose of PASIVON 20 MG is missed?

If you miss a dose of PASIVON 20 MG for conditions like erosive esophagitis and it is within 12 hours of your usual time, take it as soon as you remember. If it has been more than 12 hours, skip the missed dose and resume your regular dosing schedule. For H. pylori infection, if you miss a dose within 4 hours of your usual time, take it as soon as possible. If it has been more than 4 hours, skip the missed dose. Never take a double dose to make up for a missed one.

How should PASIVON 20 MG be stored?

PASIVON 20 MG should be stored in a cool, dry place, typically below 30°C (86°F), away from direct sunlight and moisture. Keep the medication out of the sight and reach of children.