Diamicron Xr Mex 60/1000 Mg Tablet (10 Tab)

DIAMICRON XR MEX 60/1000 MG TABLET

Name

• Brand Name: Diamicron XR MEX
• Common Name: Gliclazide and Metformin Extended Release

Composition Each tablet contains two active ingredients:

• Gliclazide: 60 mg (Extended Release)
• Metformin Hydrochloride: 1000 mg (Extended Release)

Uses Diamicron XR MEX 60/1000 MG Tablet is prescribed for the management of type 2 diabetes mellitus in adults. It is typically used when diet, exercise, and weight loss alone are insufficient to control blood glucose levels or when single-agent therapy fails. This medication helps to lower blood sugar and reduce the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart attack, or stroke.

Dosage and Administration The tablet should be taken orally with food, usually once daily, preferably with the evening meal, or as directed by a healthcare professional. It is crucial to swallow the tablet whole and not to crush, chew, or break it, as this may affect its extended-release properties. The exact dosage will be determined by the doctor based on the individual's medical condition and response to treatment.

Side Effects

• Common Side Effects: Hypoglycemia (low blood sugar), characterized by symptoms such as dizziness, sweating, headaches, trembling, palpitations, and hunger pangs. Other common effects may include stomach ache, indigestion, nausea, vomiting, diarrhea, constipation, altered taste, upper respiratory tract infection, and flatulence.
• Serious Side Effects: Rarely, serious conditions like lactic acidosis can occur, particularly with alcohol consumption or in patients with severe kidney/liver disease. Long-term use may also lead to vitamin B12 deficiency.

Precautions

• Hypoglycemia: Patients should be educated on the symptoms of low blood sugar and advised to carry a fast-acting source of glucose.
• Alcohol Consumption: Avoid or limit alcohol intake as it can significantly increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy and Breastfeeding: Diamicron XR MEX is not recommended during pregnancy or breastfeeding due to potential risks to the unborn or nursing infant. Insulin is often preferred for managing diabetes in pregnant individuals.
• Kidney and Liver Disease: Use with caution in patients with mild to moderate kidney or liver impairment. It is not recommended for those with severe kidney or liver disease, and regular monitoring of kidney and liver function is advised.
• Allergies: Do not take this medicine if you are allergic to Gliclazide, Metformin, or any other components of the tablet.
• Other Conditions: Not suitable for type 1 diabetes, diabetic ketoacidosis, diabetic pre-coma/coma, or severe heart disease.
• Drug Interactions: Inform your doctor about all other medications you are taking, as Diamicron XR MEX can interact with various drugs, including other antidiabetic medicines, diuretics, corticosteroids, certain antibiotics (fluoroquinolones), anticoagulants, and contrast agents.
• Driving and Machinery: Patients should be cautious when driving or operating machinery due to the potential for dizziness or hypoglycemic episodes.

Storage Store Diamicron XR MEX 60/1000 MG Tablet in a cool and dry place, below 30°C (or between 10°C to 25°C), protected from direct sunlight, light, and moisture. Keep out of the sight and reach of children.

DIAMICRON XR MEX 60/1000 MG TABLET is a combination medication containing Gliclazide (60 mg, extended-release) and Metformin (1000 mg) used to manage Type 2 diabetes mellitus. It is prescribed for adults when diet and exercise alone are not sufficient to control blood sugar levels.

What is DIAMICRON XR MEX 60/1000 MG TABLET used for?

DIAMICRON XR MEX 60/1000 MG TABLET is primarily used for the treatment and management of Type 2 diabetes mellitus in adults. It helps to control high blood sugar levels and, by doing so, can reduce the risk of long-term diabetes complications such as kidney damage, blindness, nerve damage, heart attack, and stroke.

How does DIAMICRON XR MEX 60/1000 MG TABLET work?

This medicine combines two active ingredients: Gliclazide and Metformin.

• Gliclazide (XR): This is a sulfonylurea that stimulates the beta cells in the pancreas to release more insulin. The "XR" (extended-release) formulation ensures a slow and consistent release of Gliclazide, providing sustained blood sugar control throughout the day.
• Metformin: This is a biguanide that works by reducing the amount of glucose produced by the liver, delaying glucose absorption from the intestines, and improving the body's sensitivity to insulin. Together, these actions help to lower blood sugar levels effectively.

What is the usual dosage of DIAMICRON XR MEX 60/1000 MG TABLET?

The typical starting dose is one tablet daily, usually taken orally with breakfast or your main meal. It is important to swallow the tablet whole and not to crush, chew, or break it, as this can affect its extended-release mechanism. Your doctor will determine the appropriate dosage based on your blood glucose levels and overall health condition, and it may be adjusted over time.

What are the possible side effects of DIAMICRON XR MEX 60/1000 MG TABLET?

Common side effects can include hypoglycemia (low blood sugar), which may manifest as dizziness, sweating, palpitations, and hunger pangs. Other frequently reported side effects are nausea, diarrhea, stomach pain, headache, taste disturbance (often a metallic taste), and upper respiratory symptoms. In rare cases, more serious side effects like lactic acidosis or vitamin B12 deficiency can occur with long-term Metformin use. If you experience any severe or persistent side effects, you should consult your doctor immediately.

Is it safe during pregnancy or breastfeeding?

DIAMICRON XR MEX 60/1000 MG TABLET is generally not recommended for use during pregnancy, as there is evidence of risk to the developing baby. For breastfeeding mothers, it is also considered probably unsafe as limited human data suggests the drug may pass into breast milk and harm the baby. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding to discuss alternative treatment options.

Can it be taken with other medications?

DIAMICRON XR MEX 60/1000 MG TABLET can interact with several other medications, including other anti-diabetic agents (like insulin), diuretics (water pills), corticosteroids, beta-blockers, and certain antifungal or anti-hypertensive medicines. Inform your doctor about all other medications, supplements, and herbal remedies you are taking to avoid potential drug interactions.

What precautions should be taken?

Avoid alcohol consumption while taking this medicine as it can increase the risk of hypoglycemia (low blood sugar). Caution is advised if you have liver or kidney problems, heart disease, or glucose-6-phosphate dehydrogenase (G6PD) deficiency. Regular monitoring of blood sugar levels is essential, and your doctor may recommend annual blood tests for vitamin B12 levels and thyroid-stimulating hormone (TSH). Due to the risk of hypoglycemia, use caution when driving or operating machinery if you experience dizziness or changes in blood sugar.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can cause a drastic and dangerous fall in blood glucose levels.

How should it be stored?

DIAMICRON XR MEX 60/1000 MG TABLET should be stored in a cool and dry place, away from direct sunlight, typically below 30°C. Keep the medicine out of sight and reach of children.