Glucreta Sm 10/100/500 Tab

GLUCRETA SM 10/100/500 TAB

GLUCRETA SM 10/100/500 Tablet is a combination medication manufactured by Torrent Pharmaceuticals Ltd., used in the management of type 2 diabetes mellitus.

Composition Each tablet contains:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg
• Metformin Hydrochloride: 500 mg

Uses GLUCRETA SM 10/100/500 Tablet is prescribed for adults with type 2 diabetes mellitus to improve blood sugar control. It is used as an adjunct to diet and exercise, particularly when blood sugar levels are not adequately controlled by metformin alone or by dual therapy. This medicine aids in the proper utilization of insulin, thereby lowering blood sugar levels, and may also help with weight loss and reduce the risk of cardiovascular disease in some patients with type 2 diabetes.

Dosage and Administration This medicine should be taken in the dose and duration as advised by your doctor. The tablet should be swallowed whole with water and not chewed, crushed, or broken. GLUCRETA SM can be taken with or without food, but it is recommended to take it at the same time every day for optimal benefits and to help reduce gastrointestinal discomfort if taken with meals. Do not stop taking this medicine without consulting your doctor.

Side Effects Common side effects may include:

• Diarrhea
• Nausea
• Vomiting
• Genital fungal infection
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Urinary tract infection
• Headache

Serious side effects, though rare, require immediate medical attention and may include signs of lactic acidosis (weakness, breathing difficulty, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), painful or persistent genital or urinary infections, signs of pancreatitis (severe stomach pain or nausea), or allergic reactions (rash, swelling, breathing problems).

Precautions

• Kidney and Liver Issues: Inform your doctor if you have any kidney or liver problems, as this medicine is contraindicated in severe renal impairment and hepatic impairment due to potential risks like lactic acidosis.
• Dehydration: Drinking plenty of fluids is essential to prevent dehydration, especially when taking this medicine.
• Alcohol: Avoid excessive alcohol intake, as it may increase the risk of some side effects, including lactic acidosis.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding, as information on its safety in these conditions is limited or not recommended.
• Drug Interactions: Inform your doctor about all other medicines, herbals, or supplements you are taking to avoid possible interactions, particularly with diuretics, insulin, and insulin secretagogues, which may cause extremely low blood sugar levels.
• Type 1 Diabetes: GLUCRETA SM is only for adults with type 2 diabetes and should not be used in people with type 1 diabetes.
• Hypoglycemia: Monitor blood sugar levels regularly, as hypoglycemia may occur when taken with other antidiabetic medicines or with delayed/skipped meals.

Storage Store below 30°C in a cool and dry place, away from direct sunlight. Keep out of reach of children and pets.

GLUCRETA SM 10/100/500 Tablet is a prescription medicine used for the management of type 2 diabetes mellitus in adults. It contains three active ingredients: Dapagliflozin (10 mg), Sitagliptin (100 mg), and Metformin (500 mg). This combination therapy is typically prescribed when diet, exercise, and treatment with a single or dual therapy of these components have not adequately controlled blood sugar levels. The medication works by targeting different pathways to help lower blood glucose, aid in weight management, and reduce cardiovascular risk.

Here are some frequently asked questions about GLUCRETA SM 10/100/500 Tablet:

What is GLUCRETA SM 10/100/500 Tablet used for?

GLUCRETA SM 10/100/500 Tablet is used to treat type 2 diabetes mellitus in adults. It helps improve blood sugar control when diet and exercise alone are not sufficient, or when metformin alone or dual therapy with metformin and either dapagliflozin or sitagliptin is inadequate. This medicine also aids in weight management and helps reduce cardiovascular risk in some individuals.

How does GLUCRETA SM 10/100/500 Tablet work?

This tablet combines three active ingredients that work in different ways to control blood sugar:

• Dapagliflozin (10 mg): A sodium-glucose co-transporter 2 (SGLT2) inhibitor that decreases the reabsorption of glucose in the kidneys, leading to more glucose being excreted through urine.
• Sitagliptin (100 mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of incretin hormones (like GLP-1 and GIP), which in turn boost insulin production and release from the pancreas and reduce glucagon secretion, especially when blood sugar levels are high.
• Metformin (500 mg): A biguanide that reduces glucose production in the liver, decreases glucose absorption from the intestines, and enhances the body's sensitivity to insulin. The combined effect of these three drugs offers multi-targeted control of blood sugar levels.

What is the usual dosage for GLUCRETA SM 10/100/500 Tablet?

The dosage of GLUCRETA SM 10/100/500 Tablet is determined by your doctor based on your individual needs and blood sugar levels. It is typically taken once or twice daily, usually with meals to minimize gastrointestinal side effects. You should swallow the tablet whole with a glass of water and avoid crushing or chewing it. It's important to take it at the same time each day for optimal benefits. Do not exceed the prescribed dose or stop the medication without consulting your doctor.

What are the possible side effects of GLUCRETA SM 10/100/500 Tablet?

Common side effects may include:

• Genital infections (e.g., fungal infections)
• Urinary tract infections (UTIs)
• Common cold, nasopharyngitis (inflammation of the throat and nasal passages), or influenza
• Headache
• Nausea, vomiting, diarrhea, or abdominal pain
• Back pain
• Cough

Less common but serious side effects can include lactic acidosis (symptoms like rapid breathing, stomach pain, muscle cramps), ketoacidosis, severe allergic reactions (rash, swelling, breathing problems), or pancreatitis. If you experience any severe or persistent side effects, or symptoms like unusual weakness, breathing difficulty, or severe abdominal pain, contact your doctor immediately.

Is GLUCRETA SM 10/100/500 Tablet safe during pregnancy or breastfeeding?

GLUCRETA SM 10/100/500 Tablet is generally not recommended during pregnancy or breastfeeding. There is limited information on its effect in pregnant women, and metformin, one of its components, is known to pass into human breast milk. It is crucial to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding, to discuss the potential risks and benefits.

Can GLUCRETA SM 10/100/500 Tablet be taken with other medications?

GLUCRETA SM 10/100/500 Tablet can interact with certain medications. Inform your doctor about all prescription, over-the-counter medicines, herbal supplements, and vitamins you are taking or plan to take.

• Diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of volume depletion or lactic acidosis.
• Insulin and insulin secretagogues (e.g., glimepiride) may increase the risk of hypoglycemia (low blood sugar), potentially requiring a dosage adjustment.
• Corticosteroids may affect blood sugar levels.
• Alcohol should be limited or avoided as it can increase the risk of lactic acidosis.

What precautions should be taken while taking GLUCRETA SM 10/100/500 Tablet?

• Do not take this medicine if you are allergic to dapagliflozin, sitagliptin, metformin, or any other components.
• Inform your doctor if you have kidney disease (especially severe impairment), liver disease, heart failure, respiratory failure, or a history of metabolic acidosis (including diabetic ketoacidosis), as the medicine may be contraindicated or require caution.
• Regular monitoring of blood sugar levels and kidney function is crucial during treatment.
• Maintain good hygiene to help prevent genital fungal infections.
• Stay well-hydrated by drinking plenty of fluids.
• Avoid excessive alcohol consumption.
• The medicine is not recommended for children under 18 years of age.

What happens if a dose of GLUCRETA SM 10/100/500 Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to a rapid drop in blood sugar levels.

How should GLUCRETA SM 10/100/500 Tablet be stored?

Store GLUCRETA SM 10/100/500 Tablet in a cool and dry place, below 30°C, away from direct sunlight. Keep it out of the sight and reach of children and pets.