Exduo 50 Tab

EXDUO 50 Tablet, manufactured by Emcure Pharmaceuticals Ltd., is a combination medication primarily used for the management of chronic heart failure. It helps improve heart function, reduce hospitalizations, and lower the risk of cardiovascular-related mortality.

Composition

EXDUO 50 Tablet contains two active ingredients:

• Sacubitril (24mg): A neprilysin inhibitor that works by relaxing and widening blood vessels, increasing the excretion of sodium through urine, and helping the body retain less water.
• Valsartan (26mg): An angiotensin receptor blocker (ARB) that blocks the effect of angiotensin II receptors, which constrict blood vessels. This makes it easier for the heart to pump blood to all parts of the body.

Uses

EXDUO 50 Tablet is prescribed for:

• Treatment of chronic heart failure with reduced ejection fraction in adults.
• Reducing the risk of hospitalization and death in patients with long-lasting (chronic) heart failure.
• Management of hypertension (high blood pressure) by reducing strain on the heart.

Dosage and Administration

EXDUO 50 Tablet should be taken orally, whole with a glass of water, and should not be crushed or chewed. It can be taken with or without food, preferably at the same time each day for optimal results. The dosage and frequency are determined by a healthcare professional based on the patient's response and condition. It is crucial to take the medication consistently as prescribed and not to stop taking it even if symptoms improve, to prevent future complications.

Side Effects

Common side effects include:

• Dizziness, lightheadedness, and fatigue
• Low blood pressure (hypotension)
• Elevated potassium levels in the blood (hyperkalemia)
• Cough
• Impaired renal function
• Nausea, diarrhea, stomach pain
• Headache and weakness

Serious side effects, requiring immediate medical attention, include angioedema (swelling of the face, lips, tongue, or throat leading to breathing difficulties), hallucinations, and changes in sleep patterns.

Precautions

• Allergies: Contraindicated in patients with a known allergy to sacubitril, valsartan, or any other components of the medicine.
• Pregnancy and Breastfeeding: EXDUO 50 Tablet is contraindicated during pregnancy and not recommended for use in breastfeeding women due to potential harm to the fetus or infant.
• Drug Interactions:
  • Avoid concomitant use with ACE inhibitors; a washout period of at least 36 hours is required before or after taking an ACE inhibitor.
  • Use with NSAIDs may impair kidney function and reduce the antihypertensive effect.
  • Combining with other antihypertensive agents can lead to excessive lowering of blood pressure.
  • Potassium supplements and potassium-rich foods (e.g., bananas, broccoli) should be avoided as they can increase blood potassium levels.
• Medical Conditions:
  • Use with caution in patients with kidney disease (especially severe) or liver disease (mild to moderate). It is contraindicated in severe liver disease.
  • Caution is advised in elderly patients.
• Alcohol: It is advisable to limit alcohol intake as it can further lower blood pressure and worsen side effects like dizziness.
• Driving and Operating Machinery: Patients should avoid driving or operating heavy machinery if they experience dizziness or fatigue.
• Monitoring: Regular monitoring of blood pressure, kidney function, and blood potassium levels is recommended during treatment.

Storage

Store EXDUO 50 Tablet below 30°C. It should be protected from moisture and light.

EXDUO 50 TAB by EMCURE PHARMACEUTICALS LTD is a combination medication containing Sacubitril (24 mg) and Valsartan (26 mg). It is primarily used to manage chronic heart failure with reduced ejection fraction.

Here are some frequently asked questions about EXDUO 50 TAB:

What is EXDUO 50 TAB used for?

EXDUO 50 TAB is used to manage chronic heart failure, particularly in adults with symptomatic heart failure who have reduced ejection fraction (meaning the heart isn't pumping blood as efficiently as it should). It helps to relax and widen blood vessels, making it easier for the heart to pump blood, improving heart efficiency, and reducing the risk of hospitalization and heart-related complications.

How does EXDUO 50 TAB work?

EXDUO 50 TAB contains two active components: Sacubitril and Valsartan. Sacubitril inhibits an enzyme called neprilysin, which is responsible for breaking down beneficial peptides that promote blood vessel dilation and improved kidney function. By blocking neprilysin, sacubitril increases the levels of these peptides. Valsartan is an angiotensin II receptor blocker (ARB) that blocks the effects of a hormone called angiotensin II, which constricts blood vessels and raises blood pressure. Together, these two components relax blood vessels, reduce fluid retention, lower blood pressure, and ease the heart's workload, ultimately improving heart function.

What is the usual dosage of EXDUO 50 TAB?

The recommended starting dose of EXDUO 50 TAB for most patients is one 50mg tablet once a day. Your doctor will determine the appropriate dose and frequency based on your medical condition and how you respond to the medication. It is crucial to follow your doctor's instructions and not to alter the dosage without consulting them. The tablet should be swallowed whole with a glass of water and can be taken with or without food, preferably at the same time each day.

What are the possible side effects of EXDUO 50 TAB?

Common side effects of EXDUO 50 TAB may include low blood pressure (hypotension), high potassium levels (hyperkalemia), kidney dysfunction, cough, dizziness, diarrhea, headache, and fatigue. More severe side effects, though rare, can include angioedema (swelling of the face, lips, tongue, or throat, potentially leading to breathing difficulties). If you experience any serious or persistent side effects, you should consult your doctor immediately.

Is EXDUO 50 TAB safe during pregnancy or breastfeeding?

EXDUO 50 TAB is generally not recommended during pregnancy and is contraindicated, especially after the first three months, as it can harm the unborn baby. It is also not recommended for use in breastfeeding women due to the risk of the drug passing into breast milk and potentially harming the baby. Always consult your doctor for safer alternatives if you are pregnant, planning to become pregnant, or breastfeeding.

Can it be taken with other medications?

EXDUO 50 TAB can interact with several other medications. Concomitant use with ACE inhibitors or other Angiotensin Receptor Blockers (ARBs) is not recommended and can increase the risk of angioedema, low blood pressure, and kidney problems. Taking it with potassium-sparing diuretics or potassium supplements can increase the risk of high potassium levels. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) may reduce its blood pressure-lowering effect and increase the risk of kidney problems. Other medications like aliskiren (especially in patients with diabetes or kidney disease) and lithium can also interact. It is crucial to inform your doctor about all medications, herbal preparations, and supplements you are currently taking to avoid potential drug interactions.

What precautions should be taken?

Inform your doctor if you have kidney or liver disease, low blood pressure, a history of angioedema, vomiting, or diarrhea. Caution is advised when consuming alcohol as it can further lower blood pressure and worsen dizziness. Due to potential dizziness or fatigue, avoid driving or operating heavy machinery until you know how the medicine affects you. Patients are advised to limit salt intake and avoid potassium-rich foods or supplements, as the medicine can increase potassium levels. Regular monitoring of blood pressure and kidney function is often recommended during treatment.

What happens if a dose is missed?

If you miss a dose of EXDUO 50 TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this could increase the risk of side effects.

How should it be stored?

EXDUO 50 TAB should be stored at room temperature, ideally below 30°C, and kept in its original packaging to protect it from moisture and light. Ensure it is kept out of the reach and sight of children. Do not use the medicine beyond the expiry date printed on the pack.