Oxemia 50 Mg Tablet (6 Tab)

OXEMIA 50 MG TABLET

OXEMIA 50 MG TABLET is a medication manufactured by Cadila Healthcare Ltd., also known as Zydus Lifesciences Ltd. or Zydus Healthcare Ltd.

Composition

• Active Ingredient: Desidustat 50 mg.
• Inactive Ingredients: Microcrystalline cellulose, lactose, croscarmellose sodium, hypromellose, talc, and magnesium stearate.

Uses OXEMIA 50 MG TABLET is prescribed for the management of anemia associated with chronic kidney disease (CKD) in adult patients, whether they are undergoing dialysis or not. It works by stimulating the body's natural production of erythropoietin, a hormone that promotes the production of red blood cells, thereby increasing hemoglobin levels and reducing symptoms like tiredness and weakness.

Dosage and Administration This medicine should be taken strictly as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush, chew, or break it. To maintain consistent medication levels, it is recommended to take it at the same time each day. Some sources suggest avoiding food 1 hour before and 2 hours after taking Desidustat. The precise dosage and duration of treatment are determined by the doctor based on individual factors, but typically, the starting dose for both non-dialysis and dialysis patients is 100 mg orally thrice a week (dosing 2 days apart, e.g., Monday, Wednesday, Friday), adjusted every four weeks according to hemoglobin levels, with a maximum dose not exceeding 150 mg thrice a week.

Side Effects Common side effects may include:

• Abdominal pain
• Vomiting
• Fever
• Weakness
• Headache
• Peripheral edema (swelling in the lower legs or hands)

If any side effects persist or worsen, or if severe side effects such as shortness of breath or a skin rash occur, immediate medical attention is necessary.

Precautions

• Allergies: Do not take OXEMIA 50 MG TABLET if you are allergic to Desidustat or any of its components.
• Pregnancy and Breastfeeding: Caution is advised during pregnancy, and it is not recommended during breastfeeding as it is unknown if Desidustat passes into breastmilk. Women of child-bearing potential must use appropriate contraception during treatment. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Pre-existing Medical Conditions: Inform your doctor about any pre-existing medical conditions, including a history of seizures, strokes, blood disorders (such as sickle cell anemia), liver disease, kidney disease, or cardiovascular disease, as caution may be required.
• Alcohol Consumption: Caution is advised when consuming alcohol; consult your doctor regarding its safety while taking this medication.
• Monitoring: Regular blood tests to monitor electrolyte levels (e.g., potassium), hemoglobin levels, and blood cell counts are necessary during treatment.
• Driving and Operating Machinery: Avoid activities requiring alertness, such as driving or operating heavy machinery, as this medicine may cause side effects that impair these abilities.

Storage Store OXEMIA 50 MG TABLET in a cool and dry place, away from direct sunlight. Keep it out of sight and reach of children. The tablets should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

What is OXEMIA 50 MG TABLET used for?

OXEMIA 50 MG TABLET is primarily used for the treatment and management of anemia associated with chronic kidney disease (CKD) in adult patients, whether they are on dialysis or not. It helps address the lack of sufficient red blood cells to carry oxygen throughout the body, improving symptoms like tiredness and weakness.

How does OXEMIA 50 MG TABLET work?

OXEMIA 50 MG TABLET contains Desidustat, which is an oral hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. It works by activating hypoxia-inducible factors (HIFs) in the body, stimulating the natural production of erythropoietin. Erythropoietin is a hormone that then prompts the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and the blood's oxygen-carrying capacity.

What is the usual dosage for OXEMIA 50 MG TABLET?

The exact dosage and duration of treatment for OXEMIA 50 MG TABLET will be determined by your doctor, taking into consideration your age, body weight, and specific health condition. It's crucial to take the medicine exactly as prescribed and at the same time each day to maintain consistent levels in your body. The tablets should be swallowed whole with water and not crushed, chewed, or broken. For many patients, a starting dose of 100 mg (e.g., two 50 mg tablets) orally thrice a week (e.g., Monday, Wednesday, Friday, with two days between doses) is typical, with dose adjustments made every four weeks based on hemoglobin levels. The maximum dose should not exceed 150 mg thrice weekly. It is recommended to take it without food, ideally one hour before or two hours after a meal.

What are the possible side effects of OXEMIA 50 MG TABLET?

Common side effects associated with OXEMIA 50 MG TABLET may include vomiting, abdominal pain, fever, headache, weakness, and peripheral edema (fluid accumulation or swelling, particularly in the extremities). Most of these side effects are usually mild and tend to subside as your body adjusts to the medication. However, if any side effects persist, worsen, or cause concern, it is important to consult your doctor. You should seek immediate medical attention if you experience severe side effects, shortness of breath, or a skin rash.

Is OXEMIA 50 MG TABLET safe during pregnancy or breastfeeding?

There is limited information available regarding the safety of OXEMIA 50 MG TABLET during pregnancy and breastfeeding. It is highly recommended to consult your doctor if you are pregnant, planning to conceive, suspect you might be pregnant, or are breastfeeding, before taking this medicine. Women of child-bearing potential should use appropriate contraception during treatment.

Can OXEMIA 50 MG TABLET be taken with other medications?

Before starting OXEMIA 50 MG TABLET, it is essential to inform your doctor about all other medications you are currently taking, including over-the-counter medicines, nutritional supplements, and herbal products. Some medications, such as certain anti-diabetic medicines (e.g., metformin) and blood thinners (e.g., warfarin, aspirin), might interact with OXEMIA 50 MG TABLET. While no known interactions with alcohol have been reported, it is generally advisable to consult your doctor regarding alcohol consumption while on this medication.

What precautions should be taken while taking OXEMIA 50 MG TABLET?

Several precautions should be observed when taking OXEMIA 50 MG TABLET. You should inform your doctor about any known allergies to Desidustat or any other components of the tablet. Disclose any pre-existing medical conditions, including liver disease, kidney disease, cardiovascular disease, a history of seizures, strokes, or blood disorders like sickle cell anemia. Regular monitoring of your iron levels, blood pressure, hemoglobin, and blood cell counts is crucial throughout your treatment. If you experience side effects that affect your alertness, avoid activities such as driving or operating heavy machinery. It is also important not to stop taking the medicine without first consulting your doctor.

What happens if a dose of OXEMIA 50 MG TABLET is missed?

If you miss a dose of OXEMIA 50 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should OXEMIA 50 MG TABLET be stored?

OXEMIA 50 MG TABLET should be stored in a cool and dry place, ideally at a temperature below 30 degrees Celsius. It should be protected from direct sunlight and moisture. Always keep the medicine out of the sight and reach of children and pets.