Ambistryn-s0.75gm

AMBISTRYN-S0.75GM by ABBOTT: Product Description

AMBISTRYN-S0.75GM is an antibiotic medication manufactured by Abbott, primarily used in the treatment of various bacterial infections.

• Name:

  • Brand Name: AMBISTRYN-S0.75GM
  • Common Name: Streptomycin

• Composition:

  • Active Ingredient: Streptomycin (0.75gm)

• Uses: AMBISTRYN-S0.75GM is primarily prescribed in combination with other medicines for the treatment of tuberculosis (TB), a serious infectious disease mainly affecting the lungs but capable of spreading to other body parts. It may also be used to treat other bacterial infections, including:

  • Pneumonia
  • Influenza
  • Plague (Pasteurella pestis)
  • Tularemia (Francisella tularensis)
  • Brucellosis
  • Certain bacterial endocarditis (in conjunction with penicillin)
  • Mycobacterium avium complex infections
  • Other severe gram-negative bacillary infections.

• Dosage and Administration: This medication is administered via intramuscular injection by a trained healthcare professional; it should not be self-administered. The dosage and duration of treatment are determined by the doctor based on the patient's condition. It is crucial to adhere strictly to the prescribed dosage and complete the entire course of treatment, even if symptoms improve, to prevent recurrence and antibiotic resistance.

  • Typical Adult Dosage for Tuberculosis: 15 mg per kg per day, with a maximum of 1 gram per day. For intermittent therapy, 25-30 mg per kg per day, 2-3 times per week, with a maximum of 1.5 grams per dose.

• Side Effects: Common side effects may include:

  • Skin rash
  • Vomiting, Nausea
  • Fever
  • Vertigo (spinning sensation), Dizziness
  • Weakness, feeling tired
  • Stomach upset More serious side effects, though less common, can include:
  • Hearing problems (ototoxicity, tinnitus, hearing loss)
  • Kidney function impairment or damage
  • Nerve problems or optic neuritis (swelling of the optic nerve)

• Precautions:

  • Allergies: Do not use if allergic to streptomycin or any other components of the medicine.
  • Pregnancy: AMBISTRYN-S0.75GM is unsafe during pregnancy due to definite evidence of risk to the developing baby.
  • Breastfeeding: It is generally considered safe for use during breastfeeding if prescribed, as it does not significantly cross into breast milk, but consultation with a doctor is advised.
  • Kidney/Liver Impairment: Use with caution in patients with kidney disease, and regular kidney function tests are recommended during treatment. Inform your doctor about any pre-existing liver conditions.
  • Hearing Problems: Caution is advised for patients with pre-existing hearing problems, and audiometry tests should be conducted before and during treatment.
  • Neuromuscular Disorders: Not recommended for use if you have pre-existing neuromuscular diseases as it may worsen the condition.
  • Driving: This medication can cause dizziness or impair concentration, so exercise caution when driving or operating machinery.
  • Monitoring: Regular monitoring through kidney function tests, hearing assessments, and urine analysis may be conducted during the treatment period.

• Storage: Store AMBISTRYN-S0.75GM at room temperature, away from heat and direct light. Keep it out of the reach of children and pets. Do not use the medicine past its expiry date.

Frequently Asked Questions about AMBISTRYN-S0.75GM

AMBISTRYN-S0.75GM, manufactured by Abbott, is an antibiotic containing Streptomycin. It is primarily used to treat serious bacterial infections. Here are some frequently asked questions about this medicine.

What is AMBISTRYN-S0.75GM used for?

AMBISTRYN-S0.75GM is primarily used in combination with other medicines to treat tuberculosis (TB), a serious bacterial infection that mainly affects the lungs but can spread to other body parts. It may also be used to treat other bacterial infections such as Mycobacterium avium complex, endocarditis, brucellosis, plague, tularemia, and pneumonia.

How does AMBISTRYN-S0.75GM work?

This medicine contains Streptomycin, which is an aminoglycoside antibiotic. It works by binding to the 30S ribosomal subunit within bacteria, disrupting their ability to produce essential proteins needed for growth and survival. This action ultimately leads to the death of the bacteria, clearing the infection.

What is the usual dosage of AMBISTRYN-S0.75GM?

AMBISTRYN-S0.75GM is administered as an intramuscular (IM) injection by a healthcare professional. The dosage varies significantly depending on the type and severity of the infection, the patient's weight, age, and kidney function. For tuberculosis, typical daily dosing is 15 mg/kg once a day (up to 1 gram/day), or for intermittent therapy, 25-30 mg/kg two to three times a week (up to 1.5 grams/dose). Treatment duration for TB can be at least one year. It's crucial to follow your doctor's exact instructions and not self-administer this medication.

What are the possible side effects of AMBISTRYN-S0.75GM?

Common side effects may include vertigo (spinning sensation), vomiting, nausea, numbness or tingling of the face, skin rash, fever, hives, and pain or irritation at the injection site. More serious side effects can occur, such as:

• Ototoxicity: Hearing loss (which may be permanent), ringing or roaring in the ears (tinnitus), or balance problems.
• Nephrotoxicity: Kidney damage.
• Nerve damage: Symptoms like tingling, numbness, muscle weakness, or even breathing problems and paralysis in severe cases.
• Severe allergic reactions: Hives, difficulty breathing, or swelling of the face, throat, or lips.
• Persistent diarrhea: This could be a sign of a new infection, such as Clostridioides difficile-associated diarrhea.

Report any serious or persistent side effects to your doctor immediately.

Is AMBISTRYN-S0.75GM safe during pregnancy or breastfeeding?

Pregnancy: AMBISTRYN-S0.75GM is generally not recommended during pregnancy because it can cross the placental barrier and cause permanent deafness and kidney problems in the developing baby. Your doctor will weigh the benefits against the risks if use during pregnancy is unavoidable, and you should be fully informed of the potential harm to the fetus. Breastfeeding: While it passes into breast milk, some studies and the World Health Organization (WHO) suggest it poses a minimal risk to the infant. However, breastfed infants should be monitored for thrush and diarrhea. Your doctor will help you decide whether to discontinue breastfeeding or the medication, considering its importance to your health.

Can AMBISTRYN-S0.75GM be taken with other medications?

Yes, AMBISTRYN-S0.75GM can interact with several other medications. It is crucial to inform your doctor about all prescription and over-the-counter medicines, vitamins, minerals, and herbal products you are taking. Of particular concern are other drugs that can cause neurotoxicity or nephrotoxicity, such as other aminoglycosides (e.g., gentamicin), cyclosporine, and certain cephalosporins. Diuretics like furosemide can increase the risk of ear toxicity. Using it with muscle relaxants or anesthetics can also increase the risk of breathing difficulties. Additionally, live bacterial vaccines (e.g., BCG, cholera vaccine) should be avoided.

What precautions should be taken with AMBISTRYN-S0.75GM?

Before starting treatment, inform your doctor if you have any allergies to streptomycin or other aminoglycoside antibiotics, or if you have kidney or hearing problems, or neuromuscular disorders like myasthenia gravis. During treatment, your doctor will likely monitor your kidney function and hearing closely, especially if you are elderly or have pre-existing kidney issues. Staying well-hydrated by drinking enough fluids is also recommended to help reduce the risk of kidney toxicity. This medication should only be used for bacterial infections, as using it unnecessarily can lead to antibiotic resistance.

What happens if a dose is missed?

Since AMBISTRYN-S0.75GM is administered by a healthcare professional, missed doses are usually managed in a clinical setting. If you miss an appointment for your injection, contact your doctor or healthcare provider immediately to reschedule. It is very important to complete the entire prescribed course of treatment, even if your symptoms improve, to ensure the infection is fully eradicated and to prevent the development of drug-resistant bacteria. Do not attempt to take two doses at once.

How should AMBISTRYN-S0.75GM be stored?

The dry powder form of AMBISTRYN-S0.75GM should be stored at controlled room temperature, typically between 20° to 25°C (68° to 77°F). After reconstitution (when mixed for injection), the solution can be stored at 2-8°C (in the refrigerator) for up to one month, or at -20°C (in the freezer) for longer periods. At 37°C, solutions are stable for three days.