Apraize 10

Name

• Generic: Apremilast
• Brand: APRAIZE 10

Composition

• Each tablet contains Apremilast 10 mg as the active ingredient.

Uses

• APRAIZE 10 is prescribed for the treatment of:
  • Moderate to severe plaque psoriasis in adults
  • Active psoriatic arthritis
  • Oral ulcers associated with Behçet’s disease

Dosage and Administration

• Initial titration is recommended to minimize gastrointestinal side effects:
  • Day 1: 10 mg in the morning
  • Day 2: 10 mg in the morning and 10 mg in the evening
  • Day 3 onward: Gradually increase as per prescribing information until reaching maintenance dose (commonly 30 mg twice daily)
• Tablets should be taken orally, with or without food.

Side Effects

• Common:
  • Diarrhea
  • Nausea
  • Headache
  • Upper respiratory tract infections
• Serious:
  • Severe allergic reactions
  • Depression or mood changes
  • Unexplained weight loss

Precautions

• Avoid use in patients with known hypersensitivity to Apremilast.
• Use with caution in individuals with a history of depression or suicidal thoughts.
• Dose adjustment may be necessary in patients with severe renal impairment.
• Possible drug interactions with strong CYP450 inducers (e.g., rifampin, carbamazepine) may reduce efficacy.
• Not recommended during pregnancy or breastfeeding unless prescribed by a physician.

Storage

• Store below 30°C (86°F).
• Keep in original packaging, protected from moisture and light.
• Keep out of reach of children.

What is APRAIZE 10 used for?

APRAIZE 10 contains apremilast, which is used to treat moderate to severe plaque psoriasis and active psoriatic arthritis in adults.

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How does APRAIZE 10 work?

Apremilast is a phosphodiesterase 4 (PDE4) inhibitor. It works by reducing inflammation in the body, which helps relieve symptoms like scaling, redness, and joint pain.

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What is the usual dosage of APRAIZE 10?

APRAIZE 10 is typically started at a lower dose and gradually increased to reduce the risk of side effects. The usual maintenance dose is 30 mg taken twice daily, but your doctor will provide a specific dosing schedule for you to follow, often starting with 10 mg and increasing over several days.

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What are the possible side effects of APRAIZE 10?

Common side effects include diarrhea, nausea, headache, upper respiratory tract infection, and weight loss. Less common but serious side effects may include depression or mood changes. Contact your doctor if you experience severe or persistent symptoms.

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Is APRAIZE 10 safe during pregnancy or breastfeeding?

The safety of apremilast during pregnancy or breastfeeding is not well established. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before starting this medication.

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Can APRAIZE 10 be taken with other medications?

APRAIZE 10 may interact with other medicines, especially strong CYP450 enzyme inducers such as rifampin, phenytoin, carbamazepine, and St. John’s wort, which can reduce its effectiveness. Inform your doctor about all the medications and supplements you are taking.

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What precautions should be taken while using APRAIZE 10?

• Tell your doctor if you have a history of depression or suicidal thoughts.
• Notify your doctor if you have severe kidney problems.
• Monitor your weight regularly, as significant weight loss can occur.
• Report any new or worsening mood symptoms immediately.

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What should I do if I miss a dose of APRAIZE 10?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.

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How should APRAIZE 10 be stored?

Store APRAIZE 10 at room temperature, away from moisture and heat. Keep it in its original packaging and out of reach of children.