Actoid 10

ACTOID 10 Capsule

Name:

• Brand Name: ACTOID 10 Capsule
• Common Name: Acitretin

Composition: ACTOID 10 Capsule contains Acitretin 10mg as its active ingredient. Acitretin is a retinoid, a derivative of Vitamin A, known for its anti-inflammatory and antiproliferative properties.

Uses: ACTOID 10 is primarily used to manage severe and extensive forms of psoriasis, an autoimmune skin disorder characterized by scaly, swollen, and itchy patches, especially when other treatments have been ineffective. It works by slowing down the excessive growth and thickening of skin cells, reducing redness, scaling, and inflammation associated with the condition. It may also be used for other severe keratinization disorders like ichthyosis and keratosis follicularis (Darier's disease), and lichen planus.

Dosage and Administration: ACTOID 10 Capsule should be taken orally, preferably with meals or a glass of milk, as advised by a doctor. It is typically taken once daily at the same time each day. Capsules should be swallowed whole and not crushed, chewed, or broken. The precise dosage and duration of treatment are determined by a healthcare professional based on the patient's condition and response.

Side Effects: Common side effects include dry lips, skin peeling (especially on palms and soles), nosebleeds, dry eyes, hair loss, joint pain, dry mouth, increased thirst, and changes in blood fat levels. Serious side effects can include severe allergic reactions, vision problems (especially at night), liver damage, mood changes, and rarely, suicidal thoughts. Prompt medical attention is advised if these occur.

Precautions:

• Pregnancy and Breastfeeding: ACTOID 10 is highly contraindicated during pregnancy due to a high risk of severe birth defects and should not be used by breastfeeding mothers as it can pass into breast milk. Women of childbearing potential must use effective contraception before, during, and for at least three years after treatment. Regular pregnancy tests are necessary.
• Alcohol: Alcohol consumption must be avoided during treatment and for two months after, as it can lead to the formation of a substance that remains in the body for over three years.
• Liver/Kidney Disease: Use with caution in patients with liver or kidney impairment; it is contraindicated in severe cases.
• Other: Avoid strong sunlight exposure and use sun protection as ACTOID 10 increases skin sensitivity. It may cause vision problems or dizziness, so caution is advised when driving or operating machinery. Patients with diabetes or high cholesterol should be monitored closely. Do not take vitamin A supplements or other retinoids concurrently. Blood donation is prohibited during treatment and for three years post-treatment.

Storage: Store ACTOID 10 Capsules below 30°C in a cool, dry place, away from direct sunlight. Keep out of reach of children and pets.

Here are frequently asked questions about ACTOID 10 by INTAS PHARMACEUTICALS LTD:

What is ACTOID 10 used for?

ACTOID 10 Capsule is primarily used to treat severe psoriasis in adults, a chronic autoimmune skin condition characterized by scaly, swollen, and itchy patches on the skin. It is also prescribed for other disorders of keratinization, such as ichthyosis (a genetic skin disorder causing dry, scaly skin) and Darier's disease (a rare inherited skin condition with crusted or scaly spots), as well as pityriasis and lichen planus.

How does ACTOID 10 work?

ACTOID 10 contains Acitretin, a retinoid derived from vitamin A. It works by slowing down the excessive growth and thickening of skin cells that occur in conditions like psoriasis. This medication has anti-inflammatory and antiproliferative properties, which help to reduce redness, scaling, and the thickness of affected skin.

What is the usual dosage for ACTOID 10?

ACTOID 10 Capsule should be taken once daily with food or a glass of milk, as advised by your doctor. The exact dose and duration of treatment will depend on your condition and how you respond to the medicine. It's crucial to swallow the capsule whole and not to crush, chew, or break it. For adults, a typical starting dose might be 25 to 50 mg once daily, with a maximum recommended daily dose of 75 mg.

What are the possible side effects of ACTOID 10?

Common side effects include dry lips, dry mouth, skin peeling (especially on palms and soles), nosebleeds, thinning or reddening of the skin, itching, a burning sensation on the skin, hair loss, and eye irritation. Other potential side effects can include joint pain, increased thirst, feeling cold, and changes in mood. ACTOID 10 may also cause vision problems, particularly in the dark, and can affect liver function and blood fat levels. If any side effects persist or worsen, you should inform your doctor immediately.

Is ACTOID 10 safe during pregnancy or breastfeeding?

No, ACTOID 10 is contraindicated during pregnancy as it can cause severe birth defects. Women who can become pregnant must use effective and reliable contraception during treatment and for at least three years after discontinuing the medicine. It is also not recommended during breastfeeding as it may pass into breast milk and harm the nursing baby. You should also avoid donating blood during treatment and for three years afterward.

Can ACTOID 10 be taken with other medications?

ACTOID 10 can interact with certain medications. You should not take it with tetracycline antibiotics (such as doxycycline or minocycline), methotrexate, or other retinoid medicines or vitamin A supplements containing high levels of vitamin A (more than 5000 IU per day). Additionally, its effectiveness may be reduced if taken with progestin-only contraceptives. Always inform your doctor about all medications, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using ACTOID 10?

It's important to avoid alcohol consumption during treatment and for at least two months after discontinuing the medicine, as it can increase the risk of side effects and form a harmful metabolite. ACTOID 10 can increase skin sensitivity to sunlight, so avoid strong sun exposure and use protective measures like sunscreen and clothing. The medicine may cause vision problems, especially at night, and dizziness or drowsiness, so do not drive or operate heavy machinery if you experience these effects. Inform your doctor if you have liver or kidney problems, high cholesterol, diabetes, or a history of mental health issues like depression, as dose adjustments or close monitoring may be necessary. Avoid wearing contact lenses due to possible dry eyes.

What happens if a dose of ACTOID 10 is missed?

If you miss a dose of ACTOID 10, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should ACTOID 10 be stored?

ACTOID 10 Capsules should be stored below 30°C in a cool and dry place, away from direct sunlight. Keep the medicine out of the sight and reach of children and pets. Follow the storage instructions provided on the medicine label to preserve its effectiveness.