Stiloz 50 Mg Tablet

STILOZ 50 MG TABLET

STILOZ 50 MG TABLET, manufactured by Integrace Health Pvt. Ltd., is a medication prescribed to alleviate symptoms associated with peripheral artery disease.

Name

• Brand Name: STILOZ 50 MG TABLET
• Common Name: Cilostazol 50 mg Tablet

Composition Each tablet contains 50 mg of the active ingredient Cilostazol. Inactive ingredients typically include carboxymethylcellulose calcium, corn starch, hypromellose, magnesium stearate, and microcrystalline cellulose.

Uses STILOZ 50 MG TABLET is primarily used for the treatment of intermittent claudication, a condition characterized by pain in the legs (cramping, numbness, or weakness) that occurs during walking due to insufficient blood flow. It works by widening blood vessels and preventing blood platelets from sticking together, thereby improving blood circulation to the legs and increasing the distance a patient can walk without pain.

Dosage and Administration The typical recommended dosage for cilostazol is 100 mg orally twice daily. However, a dose of 50 mg twice daily should be considered when co-administering with certain CYP3A4 or CYP2C19 inhibitors. The tablets should be taken on an empty stomach, at least 30 minutes before or 2 hours after breakfast and dinner. Patients may begin to experience improvement in 2 to 4 weeks, but the full beneficial effect may take up to 12 weeks of treatment.

Side Effects

• Common Side Effects: Headache, diarrhea, abnormal stools, palpitations, dizziness, nausea, edema (swelling), increased heart rate, and upset stomach.
• Serious Side Effects: Report immediately to your doctor if you experience allergic reactions (skin rash, hives, swelling of the face/lips/tongue/throat), signs of bleeding (bloody or black, tar-like stools; vomiting blood; unusual bruising; red or dark brown urine), symptoms of heart failure (shortness of breath, swelling of ankles/feet/hands, sudden weight gain), irregular heartbeat, chest pain, or signs of infection (fever, chills, sore throat).

Precautions STILOZ is contraindicated in patients with heart failure of any severity.

• Bleeding Risk: Use with caution in patients with an increased risk of bleeding, including those with active ulcers, bleeding disorders, or those taking other antiplatelet or anticoagulant medications.
• Drug Interactions: Avoid consuming grapefruit or grapefruit juice, as it can increase the level of cilostazol in the body and the risk of side effects. Dose adjustments may be necessary when taken with inhibitors of CYP3A4 (e.g., ketoconazole, erythromycin) or CYP2C19 (e.g., omeprazole).
• Other Conditions: Inform your doctor if you have severe kidney or moderate to severe liver disease, or a history of heart problems, stroke, or diabetes with eye problems.
• Driving and Machinery: This medicine may cause dizziness; therefore, caution is advised when driving or operating machinery until you know how it affects you.
• Smoking: Smoking can worsen intermittent claudication and may reduce the effectiveness of STILOZ.

Storage Store STILOZ 50 MG TABLET at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F), with brief excursions permitted between 15°C to 30°C (59°F to 86°F). Keep the container tightly closed and protect from light.

What is STILOZ 50 MG TABLET used for?

STILOZ 50 MG TABLET contains the active ingredient Cilostazol, which is primarily used to alleviate the symptoms of intermittent claudication. This condition is characterized by leg pain, cramping, numbness, or weakness that occurs during walking or exercise due to insufficient blood flow to the legs, and typically improves with rest. The medication helps to increase the distance you can walk without pain.

How does STILOZ 50 MG TABLET work?

STILOZ 50 MG TABLET works as a phosphodiesterase type 3 (PDE3) inhibitor. It functions by dilating (widening) blood vessels, particularly those supplying blood to your legs, and by preventing platelets in the blood from sticking together and forming clots. This dual action improves blood flow and oxygen delivery to the muscles, thereby reducing pain and discomfort.

What is the usual dosage for STILOZ 50 MG TABLET?

The usual adult dose of cilostazol, the active ingredient, is typically 100 mg taken orally twice a day. However, your doctor may prescribe STILOZ 50 MG TABLET (50 mg twice daily) if you are taking other medications that might interact with cilostazol, as these can increase the concentration of the medicine in your body. It should be taken at least 30 minutes before or 2 hours after breakfast and dinner on an empty stomach.

What are the possible side effects of STILOZ 50 MG TABLET?

Common side effects may include headache, diarrhea, dizziness, palpitations (a sensation of a racing or skipping heartbeat), abnormal stools, indigestion, and ankle swelling. More serious, but less common, side effects can include severe allergic reactions (rash, hives, swelling of the face/lips/tongue/throat), bleeding disorders (unusual bruising or bleeding, black/tarry stools, blood in urine/stools), and heart problems (irregular heartbeat, fast heartbeat, chest pain, symptoms of heart failure). If you experience any severe side effects, contact your doctor immediately.

Is STILOZ 50 MG TABLET safe during pregnancy or breastfeeding?

STILOZ 50 MG TABLET is generally not recommended for use during pregnancy, and its use is contraindicated. Similarly, it is not advised for breastfeeding mothers as the active component can pass into breast milk and may harm the baby. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can STILOZ 50 MG TABLET be taken with other medications?

STILOZ 50 MG TABLET can interact with several other medications. It should be used with caution, or the dosage may need adjustment, if you are taking:

• Blood thinners: Medications like aspirin, warfarin, clopidogrel, or other antiplatelet agents can increase the risk of bleeding.
• Certain antibiotics: Erythromycin and clarithromycin can increase the effectiveness of STILOZ.
• Antifungal medications: Ketoconazole, itraconazole, and fluconazole can decrease the clearance of STILOZ from the body.
• Antacids: Omeprazole can increase the effect of STILOZ.
• Blood pressure-lowering medications: Concomitant use may lead to excessively low blood pressure. It is crucial to inform your doctor about all medications, supplements, and herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while taking STILOZ 50 MG TABLET?

You should not take STILOZ 50 MG TABLET if you have heart failure of any severity, active bleeding disorders (such as stomach ulcers or recent stroke), or severe kidney or liver problems. It can cause dizziness and affect alertness, so avoid driving or operating heavy machinery until you know how it affects you. Smoking can reduce the medication's effectiveness and worsen your condition, so quitting smoking is recommended. Additionally, avoid consuming grapefruit or grapefruit juice while on this medication, as it can increase the risk of side effects.

What happens if a dose of STILOZ 50 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should STILOZ 50 MG TABLET be stored?

Store STILOZ 50 MG TABLET at room temperature, typically between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit), away from excessive heat, moisture, and direct light. Keep the medication in its original closed container and out of the reach of children and pets. Do not use the medicine after its expiration date.