Dapavel S 10/100

DAPAVEL S 10/100

DAPAVEL S 10/100 is a medication manufactured by Intas Pharmaceuticals Ltd.

• Composition Each tablet contains Dapagliflozin 10 mg and Sitagliptin 100 mg. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.

• Uses DAPAVEL S 10/100 is primarily prescribed for the management of type 2 diabetes mellitus in adults, particularly when blood sugar levels are not adequately controlled by diet and exercise alone. This medication also helps in lowering high blood sugar levels, reducing cardiovascular risk in patients with type 2 diabetes, slowing the progression of kidney disease, and managing heart failure in certain patients. It is not suitable for treating Type 1 diabetes or diabetic ketoacidosis.

• Dosage and Administration The typical starting dose is one tablet daily, taken orally. It can be taken with or without food, but it is important to take it at the same time each day to maintain consistent medication levels in the body. Tablets should not be crushed, chewed, or broken. Dosage adjustments should only be made by a doctor, and the medication should not be discontinued without medical advice.

• Side Effects

  • Common Side Effects: These may include urinary tract infections (UTIs), genital infections (e.g., thrush), frequent urination, headache, nausea, vomiting, diarrhea, abdominal pain, common cold, back pain, joint pain, dizziness, constipation, skin rash, increased thirst, nasal congestion, and sore throat.
  • Serious Side Effects (Seek immediate medical attention if experienced): Severe and persistent stomach pain (possibly indicating inflamed pancreas), serious allergic reactions (rash, hives, swelling of the lips, tongue, face, and throat), diabetic ketoacidosis (symptoms include nausea, vomiting, confusion, sweet smell to breath), Fournier's gangrene (a serious genital infection), and kidney problems. Hypoglycemia (low blood sugar) can also occur, especially when used with other antidiabetic medications.

• Precautions DAPAVEL S 10/100 is not recommended for individuals with Type 1 diabetes or diabetic ketoacidosis. Caution should be exercised in patients with severe kidney impairment, end-stage renal disease, or those on dialysis, as well as those with severe liver disease, a history of pancreatitis, or gallstones. Inform your doctor about all existing medical conditions and other medications, supplements, or herbal products you are taking, particularly diuretics or insulin secretagogues, to avoid potential drug interactions and increased risk of low blood sugar. Excessive alcohol consumption should be avoided as it may affect blood sugar control. Maintaining good hygiene is important to prevent genital infections, and adequate fluid intake helps prevent dehydration. Pregnant or breastfeeding women should consult their doctor before using this medication. This medication is not recommended for children under 18 years of age. If you experience dizziness, avoid driving or operating heavy machinery.

• Storage Store DAPAVEL S 10/100 in a cool and dry place, away from direct sunlight. Keep this medicine out of the sight and reach of children.

Frequently Asked Questions (FAQs) about DAPAVEL S 10/100

What is DAPAVEL S 10/100 used for?

DAPAVEL S 10/100 is a combination medicine used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed when diet and exercise alone, or other diabetes medications, are not sufficient to control blood sugar. This medication also helps reduce the risk of serious complications of diabetes, such as kidney damage, nerve damage, and cardiovascular events.

How does DAPAVEL S 10/100 work?

DAPAVEL S 10/100 contains two active ingredients: Dapagliflozin and Sitagliptin, which work through different mechanisms. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that helps the kidneys remove excess glucose from the body through urine, thereby lowering blood sugar levels. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the body's natural incretin hormones, which, in turn, stimulates insulin release after meals and reduces glucose production by the liver.

What is the usual dosage for DAPAVEL S 10/100?

The usual dosage for DAPAVEL S 10/100 is typically one tablet once daily, taken orally. It can be taken with or without food. It is recommended to take the medicine at the same time each day to maintain consistent blood sugar control. Your doctor will determine the appropriate dosage based on your medical condition and response to treatment. Do not alter the dosage or stop the medication without consulting your doctor.

What are the possible side effects of DAPAVEL S 10/100?

Common side effects of DAPAVEL S 10/100 can include urinary tract infections (UTIs), genital fungal infections, headache, dizziness, low blood sugar (hypoglycemia), nausea, diarrhea, and frequent urination. More serious but rare side effects can include diabetic ketoacidosis and Fournier's gangrene. If you experience any severe or persistent side effects, or symptoms like excessive thirst, confusion, or abdominal pain, contact your doctor immediately.

Is DAPAVEL S 10/100 safe during pregnancy or breastfeeding?

DAPAVEL S 10/100 is generally not recommended during the second and third trimesters of pregnancy due to one of its active ingredients, dapagliflozin. Limited data is available regarding its effects during breastfeeding, and it may pass into breast milk. Therefore, pregnant or breastfeeding women should consult their doctor for advice, as they may prescribe this medicine only if the benefits outweigh the risks.

Can DAPAVEL S 10/100 be taken with other medications?

DAPAVEL S 10/100 can interact with certain medications. It is important to inform your doctor about all other medicines, herbal products, and supplements you are currently taking. Particular caution is advised when taking it with diuretics (e.g., furosemide, hydrochlorothiazide), insulin, insulin secretagogues (e.g., sulphonylureas), certain antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir), antibiotics (e.g., clarithromycin), and cardiac glycosides (e.g., digoxin), as these can increase the risk of side effects or affect blood sugar control.

What precautions should be taken while taking DAPAVEL S 10/100?

Before starting DAPAVEL S 10/100, inform your doctor if you have kidney or liver problems, a history of urinary tract infections, or heart failure. It is important to stay well-hydrated by drinking plenty of fluids to prevent dehydration, which can be a side effect. Avoid excessive alcohol consumption, as it can interfere with blood sugar control. Regular monitoring of blood sugar levels is crucial. Do not stop taking the medicine abruptly, even if your blood sugar levels are stable, as this can lead to a rebound increase in blood sugar.

What happens if a dose of DAPAVEL S 10/100 is missed?

If you miss a dose of DAPAVEL S 10/100, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should DAPAVEL S 10/100 be stored?

DAPAVEL S 10/100 should be stored in a cool and dry place below 30°C, away from direct sunlight. Keep it in its original packaging to protect it from light and moisture. Always keep this medicine out of the reach of children and pets.