Natrilix Sr Tablet (10 Tab)

NATRILIX SR TABLET (10 TAB) by SERDIA PHARMACEUTICALS (INDIA) PVT. LTD.

• Name:

  • Brand Name: Natrilix SR Tablet
  • Common Name: Indapamide prolonged-release film-coated tablets

• Composition:

  • Active Ingredient: Each sustained-release tablet contains 1.5 mg of Indapamide hemihydrate.
  • Other Ingredients: Anhydrous colloidal silica, hypromellose, lactose monohydrate, magnesium stearate, povidone, glycerol, macrogol 6000, and titanium dioxide.

• Uses: Natrilix SR Tablet is a diuretic (water pill) primarily used for:

  • Treating essential hypertension (high blood pressure) in adults.
  • Reducing excess fluid levels and treating edema (fluid overload) associated with conditions like heart failure, liver disease, or kidney disease. It works by increasing the excretion of sodium and water from the body, thereby lowering blood pressure and reducing fluid build-up.

• Dosage and Administration:

  • The recommended dose for adults is one tablet (1.5 mg) daily, taken orally in the morning.
  • Tablets should be swallowed whole with water and not crushed or chewed.
  • Taking more than the prescribed dose is not recommended as it does not significantly enhance the antihypertensive effect but increases the diuretic effect and electrolyte disturbances.
  • Treatment for high blood pressure is usually long-term; consult a doctor before discontinuing.

• Side Effects: Common side effects may include:

  • Headache
  • Fatigue, feeling tired, or having less energy
  • Dizziness, light-headedness, or feeling faint
  • Nausea
  • Abdominal pain or gastrointestinal symptoms
  • Skin rash or itching
  • Muscle cramps or weakness Serious side effects, though rare, can include severe allergic reactions (skin rash, swelling of the face/tongue/throat, breathing difficulty), severe dehydration, and significant electrolyte imbalances (low potassium, sodium, magnesium, or chloride).

• Precautions:

  • Contraindications: Do not take if allergic to indapamide, sulfonamides, or any other ingredients. Also contraindicated in severe kidney disease (anuria), severe liver disease (hepatic encephalopathy), or low blood potassium levels.
  • Interactions: Avoid co-administration with lithium. Caution is advised with other diuretics, certain heart rhythm medicines, some steroids, NSAIDs, and medicines for diabetes or gout.
  • Driving/Operating Machinery: May cause dizziness or drowsiness, especially at the start of treatment or after dose increases. Avoid such activities until you know how the medicine affects you.
  • Alcohol: Avoid alcohol consumption as it may worsen dizziness and lead to a sudden drop in blood pressure.
  • Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding unless specifically advised by a doctor.
  • Photosensitivity: May increase skin sensitivity to the sun; protection from sun exposure is recommended.
  • Electrolyte Monitoring: Regular blood tests may be required to monitor kidney function and electrolyte levels (especially potassium).
  • Diabetes: Use with caution as it may increase blood sugar levels.
  • Children: Not approved for use in children younger than 18 years due to lack of safety and efficacy data.

• Storage:

  • Store in a cool, dry place below 30°C, or below 25°C in some regions, away from direct sunlight.
  • Keep out of sight and reach of children.

What is NATRILIX SR TABLET used for?

NATRILIX SR TABLET is primarily used to treat hypertension (high blood pressure) in adults. As a diuretic, it also helps reduce excess fluid levels in the body, treating edema (fluid overload) associated with conditions affecting the heart, liver, kidneys, or lungs.

How does NATRILIX SR TABLET work?

NATRILIX SR TABLET contains indapamide, which is a thiazide-like diuretic. It works by inhibiting the reabsorption of sodium in the cortical dilution segment of the kidneys. This action increases the excretion of sodium, chloride, and water through urine, which reduces blood volume. Additionally, indapamide relaxes blood vessels, leading to improved blood flow and a reduction in blood pressure.

What is the usual dosage for NATRILIX SR TABLET?

The recommended dosage for adults is one 1.5 mg tablet daily, to be taken orally, preferably in the morning. The tablet should be swallowed whole with water and should not be crushed or chewed. Taking a higher dose than one tablet daily is not recommended as it does not significantly enhance the blood pressure-lowering effect but can increase the diuretic effect and electrolyte disturbances.

What are the possible side effects of NATRILIX SR TABLET?

Common side effects include headache, fatigue, nausea, gastrointestinal symptoms, muscle cramps, dizziness, and skin rash. This medication can also cause changes in laboratory parameters such as low potassium, magnesium, chloride, or sodium levels in the blood, an increase in uric acid (which may cause or worsen gout), and increased blood glucose levels in diabetic patients. Serious but rare side effects can include severe allergic reactions, Stevens-Johnson Syndrome, and toxic epidermal necrolysis.

Is NATRILIX SR TABLET safe during pregnancy or breastfeeding?

NATRILIX SR TABLET is generally not recommended during pregnancy. If pregnancy is planned or confirmed, it is advisable to switch to an alternative treatment as soon as possible. Similarly, breastfeeding is not recommended while taking this medicine, as the active ingredient is excreted in human breast milk, and its possible effect on the newborn is unknown.

Can NATRILIX SR TABLET be taken with other medications?

NATRILIX SR TABLET can be effectively combined with certain antihypertensive medicines such as beta-blockers, methyldopa, clonidine, prazosin, and ACE inhibitors. However, it should not be taken with lithium due to the risk of increased plasma lithium levels and symptoms of overdose. Special caution and monitoring are required when taken with other diuretics, medicines for heart rhythm problems (e.g., amiodarone, sotalol), non-steroidal anti-inflammatory drugs (NSAIDs), some antipsychotics, tricyclic antidepressants, and medications that can cause hypokalemia (low potassium).

What precautions should be taken while using NATRILIX SR TABLET?

Avoid consuming alcohol as it may intensify side effects such as dizziness and a sudden drop in blood pressure. Exercise caution when driving or operating machinery, especially at the beginning of treatment, as it may cause dizziness or tiredness. Regular monitoring of kidney function and electrolyte levels (like potassium and sodium) is important. Inform your doctor if you have liver problems, diabetes, gout, any heart rhythm issues, or a history of allergy to sulfonamide medicines. Stay adequately hydrated, particularly during exercise or hot weather, and report any excessive vomiting or diarrhea to your doctor. NATRILIX SR may increase your skin's sensitivity to the sun; if this occurs, you should stop treatment and contact your doctor. This medicine is contraindicated in patients with severe kidney or liver disease (including hepatic encephalopathy) and those with low blood potassium levels. Athletes should note that indapamide may result in a positive reaction during doping tests.

What happens if a dose of NATRILIX SR TABLET is missed?

If you miss a dose of NATRILIX SR TABLET, and your next scheduled dose is more than 6 hours away, take the missed dose as soon as you remember. If your next dose is less than 6 hours away, simply skip the missed dose and take the next dose at the usual time. Do not take a double dose to compensate for a forgotten dose.

How should NATRILIX SR TABLET be stored?

NATRILIX SR TABLETS should be kept in their original packaging in a cool, dry place, typically below 25°C or 30°C, away from direct sunlight and moisture. Ensure they are stored out of sight and reach of children.