Pramirol Sr 0.26 Mg Tablet (10 Tab)

PRAMIROL SR 0.26 MG TABLET

• Name:

  • Brand Name: Pramirol SR 0.26 mg Tablet.
  • Common Name: Pramipexole Sustained-Release 0.26 mg.

• Composition:

  • Each tablet contains Pramipexole 0.26 mg as the active ingredient.

• Uses: Pramirol SR 0.26 mg Tablet is a dopamine agonist primarily used to treat certain neurological conditions.

  • Parkinson's Disease: It helps manage the symptoms of idiopathic Parkinson's disease, such as tremors, stiffness, slow movement, and poor muscle control, by mimicking the action of dopamine in the brain. It can be used alone or in combination with levodopa.
  • Willis-Ekbom Disease (Restless Legs Syndrome - RLS): It alleviates the uncomfortable urge to move the legs, especially at night, thereby improving sleep and quality of life.

• Dosage and Administration: Pramirol SR 0.26 mg Tablet is a sustained-release formulation and should be taken as advised by a doctor.

  • Typically, prolonged-release tablets are taken once daily at approximately the same time each day.
  • Tablets should be swallowed whole with water and should not be chewed, divided, or crushed to avoid overdose.
  • It can be taken with or without food; taking it with food may help reduce nausea.
  • For Restless Legs Syndrome, it is often advised to take the medicine 2 to 3 hours before bedtime.
  • Dosage is usually increased gradually over several weeks until symptoms are controlled. Do not discontinue abruptly.

• Side Effects:

  • Common Side Effects: Sleepiness, nausea, constipation, dizziness, fatigue, dry mouth, muscle spasms, and peripheral oedema (leg swelling). Other common effects can include low blood pressure and headaches.
  • Serious Side Effects: Hallucinations (seeing or hearing things that are not there), confusion, aggressive behavior, agitation, abnormal thoughts, changes in vision, and uncontrolled body movements. It may also cause impulse control disorders such as increased sex drive, gambling urges, overeating, or reckless spending. Sudden episodes of falling asleep can also occur.

• Precautions:

  • Pregnancy and Breastfeeding: Use with caution during pregnancy; consult a doctor. It is generally unsafe during breastfeeding as it can reduce breast milk production and pass into breast milk.
  • Driving and Machinery: May cause drowsiness, dizziness, and sudden sleep episodes; avoid driving or operating heavy machinery until you know how it affects you.
  • Alcohol: Avoid alcohol consumption as it can increase drowsiness and dizziness.
  • Kidney Impairment: Use with caution; dose adjustment may be necessary.
  • Other Conditions: Inform your doctor if you have heart disease, low blood pressure, liver impairment, mental health conditions, or dyskinesia.
  • Do not stop the medication suddenly without consulting a doctor.

• Storage:

  • Store in a cool and dry place, away from sunlight.
  • Keep out of sight and reach of children.
  • Store below 25°C or 30°C.

Here are frequently asked questions about PRAMIROL SR 0.26 MG TABLET (10 TAB) by INTAS PHARMACEUTICALS LTD., containing Pramipexole as the active ingredient.

What is Pramirol SR 0.26 mg used for?

Pramirol SR 0.26 mg is primarily used to treat the symptoms of Parkinson's disease, which include tremors, stiffness, slow movement, and difficulties with balance and coordination. It is also prescribed for moderate to severe Restless Legs Syndrome (RLS), also known as Willis-Ekbom disease, a condition causing an uncontrollable urge to move the legs, often with uncomfortable sensations.

How does Pramirol SR 0.26 mg work?

Pramirol SR 0.26 mg contains pramipexole, which belongs to a class of medications called dopamine agonists. It works by mimicking the action of dopamine, a natural chemical messenger in the brain that is crucial for controlling body movements. By stimulating dopamine receptors in the brain, it helps to alleviate the symptoms of Parkinson's disease and Restless Legs Syndrome.

What is the usual dosage of Pramirol SR 0.26 mg?

Pramirol SR 0.26 mg is an extended-release (SR) tablet, typically taken once a day. For Parkinson's disease, the usual starting dose for extended-release formulations is often 0.375 mg once daily (which corresponds to 0.26 mg pramipexole base) and is gradually increased by your doctor every 5-7 days until symptoms are controlled. For Restless Legs Syndrome, it is usually taken once a day, 2-3 hours before bedtime, with the dose gradually adjusted by your doctor up to a maximum of 0.5 mg per day. The tablets should be swallowed whole and not chewed, crushed, or divided, as this could lead to a rapid release of the medication. It can be taken with or without food.

What are the possible side effects of Pramirol SR 0.26 mg?

Common side effects include nausea, dizziness, drowsiness (including sudden sleep attacks without warning), headache, constipation, fatigue, dry mouth, confusion, and swelling of the arms or legs (peripheral edema). More serious side effects can include hallucinations (seeing or hearing things that aren't real), low blood pressure upon standing (orthostatic hypotension), involuntary movements (dyskinesia, especially when taken with levodopa), and impulse control disorders (such as increased urges to gamble, binge eat, or engage in compulsive shopping or sexual behaviors). You should report any serious or persistent side effects to your doctor immediately.

Is Pramirol SR 0.26 mg safe during pregnancy or breastfeeding?

Pregnancy: Pramirol SR 0.26 mg is generally not recommended during pregnancy. It is not known if it can harm an unborn baby. Your doctor will weigh the potential benefits against the risks if use during pregnancy is considered necessary.

Breastfeeding: Pramirol SR 0.26 mg is not recommended for women who are breastfeeding. The medication may pass into breast milk and could potentially harm the baby or suppress milk production. Your doctor will advise you on whether to discontinue breastfeeding or stop taking the medication.

Can Pramirol SR 0.26 mg be taken with other medications?

You should inform your doctor about all prescription, over-the-counter medications, vitamins, and herbal supplements you are taking. Pramirol SR 0.26 mg can interact with other drugs. Caution is advised when taken with CNS depressants (medicines that cause drowsiness), alcohol, and certain medications like cimetidine, amantadine, mexiletine, procainamide, zidovudine, and cisplatin. If you are also taking levodopa for Parkinson's disease, your doctor may adjust its dose as Pramirol SR can worsen dyskinesia. Alcohol should be avoided as it can increase side effects like drowsiness and dizziness.

What precautions should be taken while using Pramirol SR 0.26 mg?

Due to the risk of dizziness, drowsiness, or sudden onset of sleep, you should not drive or operate heavy machinery until you know how the medication affects you. To prevent dizziness from low blood pressure, rise slowly when standing up from a sitting or lying position. Your doctor should monitor you for any changes in mood, behavior, or the development of impulse control disorders. It should be used with caution in patients with kidney problems, as dose adjustment may be necessary. It is not recommended for individuals under 18 years of age.

What happens if a dose of Pramirol SR 0.26 mg is missed?

If you miss a dose of Pramirol SR 0.26 mg, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important not to stop taking the medication suddenly without consulting your doctor, as abrupt discontinuation can lead to serious withdrawal symptoms.

How should Pramirol SR 0.26 mg be stored?

Pramirol SR 0.26 mg should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). It should be kept in a cool, dry place and protected from light and moisture. Always keep this and all medicines out of the reach of children.