Syntran 200 Cap

SYNTRAN 200 CAP

SYNTRAN 200 CAP is an antifungal medication manufactured by Glenmark Laboratories. It is primarily prescribed for the treatment of various fungal infections throughout the body.

• Name

  • Brand Name: SYNTRAN 200 CAP
  • Common Name: Itraconazole

• Composition Each capsule contains 200 mg of Itraconazole, which is the active ingredient. Itraconazole belongs to the azole antifungals group and works by inhibiting the growth of fungi.

• Uses SYNTRAN 200 CAP is used to treat a wide range of fungal and yeast infections, including:

  • Fungal infections of the mouth, throat (oral thrush), and vagina.
  • Skin and nail infections (e.g., ringworm, onychomycosis).
  • Systemic fungal infections affecting internal organs such as the lungs (aspergillosis), and other parts of the body (candidiasis, cryptococcosis, histoplasmosis, blastomycosis).
  • As a preventive measure against fungal infections in immunocompromised individuals.

• Dosage and Administration Take SYNTRAN 200 CAP as prescribed by your doctor, usually once or twice daily. It should be swallowed whole with a glass of water, immediately after a meal for optimal absorption. It is crucial to complete the entire course of treatment, even if symptoms improve, to prevent re-infection. Avoid taking antacids within two hours before or one hour after taking this medicine as they can reduce its absorption.

• Side Effects Common side effects may include nausea, vomiting, stomach pain, headache, dizziness, diarrhea, fatigue, and rash. Serious side effects, though rare, can involve liver problems (yellowing of skin/eyes, dark urine, severe lack of appetite), irregular heartbeat, fits, and tingling or numbness in limbs. Seek immediate medical attention if you experience severe symptoms.

• Precautions

  • Contraindications: Do not use if you are allergic to itraconazole or other similar medicines, have liver problems, or heart-related disorders like irregular heartbeats or heart failure.
  • Pregnancy and Breastfeeding: SYNTRAN 200 CAP is not recommended during pregnancy due to the risk of fetal harm and should be avoided by breastfeeding women as it can pass into breast milk.
  • Drug Interactions: Inform your doctor about all medications and herbal supplements you are taking, especially antacids, certain cholesterol-lowering drugs, and medicines for irregular heartbeats, as interactions can occur.
  • Other Warnings: Caution is advised for patients with kidney disease, adrenal insufficiency, or a history of heart failure. Avoid alcohol consumption during treatment. Regular monitoring of liver function may be required during long-term therapy. If dizziness or vision changes occur, avoid driving or operating machinery.

• Storage Store SYNTRAN 200 CAP at room temperature (below 25°C or 30°C) in a cool, dry place. Protect it from direct sunlight, excess heat, and moisture. Keep out of the reach of children and pets.

SYNTRAN 200 CAP, manufactured by Glenmark Laboratories, contains Itraconazole as its active ingredient. It is an antifungal medication primarily used to treat various fungal and yeast infections throughout the body.

What is SYNTRAN 200 CAP used for?

SYNTRAN 200 CAP is used to treat a wide range of fungal infections. These include severe systemic fungal infections such as aspergillosis, candidiasis, and cryptococcosis. It also treats fungal infections of the skin and nails (like onychomycosis and dermatophytosis), oral thrush, and other mucosal candida infections. Additionally, it may be prescribed as a preventive measure against fungal infections in individuals with weakened immune systems.

How does SYNTRAN 200 CAP work?

SYNTRAN 200 CAP (Itraconazole) works by inhibiting a specific enzyme (lanosterol 14-alpha-demethylase) in fungi, which is crucial for the production of ergosterol. Ergosterol is a vital component of the fungal cell membrane. By preventing its synthesis, Itraconazole weakens and damages the fungal cell membranes, leading to increased permeability, leakage of cell contents, and ultimately, the death of the fungi, thereby clearing the infection.

What is the usual dosage for SYNTRAN 200 CAP?

The dosage and duration of treatment with SYNTRAN 200 CAP are determined by your doctor based on the type and severity of the fungal infection and your response to the medication. It is crucial to follow your doctor's instructions precisely and not to alter or exceed the prescribed dose. The capsule should be swallowed whole with water, preferably immediately after a meal to ensure optimal absorption.

What are the possible side effects of SYNTRAN 200 CAP?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, rash, itching, fatigue, and loss of appetite. Most of these side effects are usually mild and temporary. If any side effects persist, worsen, or if you experience severe symptoms like tingling, numbness, weakness in limbs, or signs of liver problems (e.g., yellowing of skin/eyes, dark urine, severe lack of appetite), you should contact your doctor immediately.

Is SYNTRAN 200 CAP safe during pregnancy or breastfeeding?

SYNTRAN 200 CAP is generally not recommended during pregnancy, especially in the first trimester, as it may pose risks to the unborn baby, including an increased chance of miscarriage or birth defects. For breastfeeding women, it is also not advised as itraconazole can pass into breast milk and may harm the baby. It is essential to discuss with your doctor if you are pregnant, planning to conceive, or breastfeeding before taking this medicine. Effective contraception is advised during treatment and for two months after stopping the medication if you are a woman of childbearing age.

Can SYNTRAN 200 CAP be taken with other medications?

SYNTRAN 200 CAP can interact with several other medications. It's crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking. Some notable interactions include certain antiarrhythmics (like quinidine and dofetilide), statins (simvastatin, atorvastatin), benzodiazepines (midazolam, triazolam), immunosuppressants (cyclosporine, tacrolimus), and some allergy medications (terfenadine, astemizole). Taking antacids should be avoided within 2 hours of taking SYNTRAN 200 CAP, as they can reduce its absorption.

What precautions should be taken with SYNTRAN 200 CAP?

Precautions include informing your doctor if you have liver, kidney, or heart problems (especially heart failure or ventricular dysfunction), as SYNTRAN 200 CAP can worsen these conditions. Avoid consuming alcohol during treatment as it may increase the risk of liver problems. If you experience dizziness or vision changes, avoid driving or operating heavy machinery. Regular monitoring of liver function through blood tests may be required during long-term treatment.

What happens if a dose is missed?

If you miss a dose of SYNTRAN 200 CAP, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a forgotten one without consulting your doctor.

How should SYNTRAN 200 CAP be stored?

Store SYNTRAN 200 CAP at a comfortable room temperature, typically below 30°C. Keep it in a cool, dry place, protected from bright light and moisture, and out of the reach of children. Always check the expiry date before use.