Sitaglo E 25/100mg Tab

SITAGLO E 25/100MG TAB

Name:

• Brand Name: SITAGLO E 25/100MG TAB
• Generic Name: Empagliflozin + Sitagliptin

Composition: Each tablet contains:

• Empagliflozin 25 mg
• Sitagliptin 100 mg

Uses: SITAGLO E 25/100MG TAB is prescribed for adults to manage type 2 diabetes mellitus. It helps to lower blood sugar levels when diet and exercise alone are not sufficient. This combination medication may also be used to treat cardiovascular disease and reduce the risk of kidney disease in appropriate patients. Empagliflozin works by helping the kidneys remove excess sugar from the body through urine, while Sitagliptin enhances insulin release and reduces sugar production.

Dosage and Administration:

• This medicine should be taken orally, once a day.
• It is generally recommended to take it preferably after meals and at the same time each day to maintain consistent blood sugar control.
• Swallow the tablet whole without chewing or crushing it.
• The dosage may be adjusted by your doctor based on your medical condition and response to treatment.
• Do not stop taking this medicine without consulting your doctor, as it can lead to increased blood sugar levels and associated complications.
• If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not take a double dose to compensate.

Side Effects: Common Side Effects:

• Headache
• Urinary tract infections (bladder pain, bloody or cloudy urine, frequent urge to urinate, painful urination)
• Upper respiratory tract infections
• Fungal infections (itching, stinging, or redness of the vaginal area, changes in vaginal discharge, pain during sexual intercourse)
• Stomach discomfort or dizziness

Serious Side Effects:

• Allergic reactions, including rash, hives, and swelling of the face, lips, tongue, or throat, which may cause difficulty in breathing or swallowing.
• Severe and persistent stomach pain, often with nausea and vomiting, which could indicate pancreatitis.
• Low blood sugar (hypoglycemia), especially when taken with other diabetes medications like sulfonylureas or insulin.
• Severe blistering or breakdown of the skin.
• Kidney problems, sometimes requiring dialysis.
• Yellowing of the eyes or skin, which can be a sign of liver problems.
• Metabolic acidosis (a rare but serious condition).

Precautions:

• SITAGLO E 25/100MG TAB is not for patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
• It is not safe for consumption during the second and third trimesters of pregnancy. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Inform your doctor if you have kidney disease, heart disease, pancreatic disease, or liver problems.
• This medicine can increase the risk of urinary tract infections.
• Avoid excessive alcohol consumption and tobacco use, as they can interact with the medication and affect blood sugar levels.
• Exercise caution if you are at risk of dehydration (e.g., from vomiting, diarrhea, fever, or while taking diuretics or blood pressure-lowering medications).
• Inform your doctor about all other medications, supplements, or herbs you are taking, particularly insulin, sulfonylureas, or lithium, to avoid potential interactions or hypoglycemia.
• This medication may cause dizziness or sleepiness; avoid driving or operating machinery if you experience these effects.
• Carry a fast-acting carbohydrate (like sugar candy) to treat episodes of low blood glucose.
• Inform your doctor if you plan to undergo surgery.

Storage:

• Store SITAGLO E 25/100MG TAB at room temperature, below 30°C or 25°C.
• Keep the tablets in their original blister pack until it is time to take them.
• Protect from direct sunlight and moisture.
• Keep out of reach of children and pets.

SITAGLO E 25/100MG TAB is a medication used for the management of Type 2 Diabetes Mellitus. It combines two active ingredients: Empagliflozin (25mg) and Sitagliptin (100mg).

Here are some frequently asked questions about SITAGLO E 25/100MG TAB:

What is SITAGLO E 25/100MG TAB used for?

SITAGLO E 25/100MG TAB is primarily used to lower and maintain blood sugar levels in adults with Type 2 Diabetes Mellitus when diet and exercise alone are not sufficient. It also offers additional benefits such as supporting cardiovascular health and reducing the risk of kidney complications associated with diabetes.

How does SITAGLO E 25/100MG TAB work?

This medication combines two different types of drugs that work in complementary ways:

• Empagliflozin: This component is a sodium-glucose co-transporter-2 (SGLT2) inhibitor. It works by blocking the SGLT2 protein in the kidneys, which prevents the reabsorption of glucose back into the bloodstream. This leads to the removal of excess sugar from the body through urine, thereby lowering blood glucose levels. Empagliflozin's effect is independent of insulin.
• Sitagliptin: This component is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of natural hormones called incretins (GLP-1 and GIP) in the body. These hormones help the pancreas release more insulin when blood sugar levels are high and reduce the amount of sugar produced by the liver, thus improving overall glucose control.

What is the usual dosage for SITAGLO E 25/100MG TAB?

The usual dose is one tablet (containing Empagliflozin 25mg and Sitagliptin 100mg) taken once a day. It can be taken at any time of day, with or without food, but it is recommended to take it at the same time each day for consistency. Your doctor will determine the exact dosage based on your condition and response to treatment.

What are the possible side effects of SITAGLO E 25/100MG TAB?

Common side effects can include urinary tract infections and genital mycotic infections (e.g., thrush), which are more common with empagliflozin due to increased sugar in the urine. Other potential side effects include headaches, feeling hungry, trembling or shaking, sweating, and confusion (signs of low blood sugar, especially when taken with insulin or sulfonylureas), stomach pain, dizziness, and dehydration. Serious but rare side effects can include severe stomach pains (pancreatitis) or signs of liver problems.

Is SITAGLO E 25/100MG TAB safe during pregnancy or breastfeeding?

SITAGLO E 25/100MG TAB is generally not recommended during pregnancy or breastfeeding. For empagliflozin, there is a theoretical risk to the infant's developing kidneys, and it is advised against during the second and third trimesters of pregnancy. For sitagliptin, there is limited information on its effects during pregnancy, and it's not usually recommended during breastfeeding as it's unknown how much passes into breast milk. If you are pregnant, planning a pregnancy, or breastfeeding, consult your doctor to discuss safer alternative treatments.

Can SITAGLO E 25/100MG TAB be taken with other medications?

SITAGLO E 25/100MG TAB can be prescribed with other diabetes medications, including metformin, sulfonylureas, or insulin. However, combining it with insulin or sulfonylureas may increase the risk of hypoglycemia (low blood sugar), and dose adjustments of these other medications might be necessary. It's crucial to inform your doctor about all medications, supplements, and herbal remedies you are taking to avoid potential interactions. Studies have shown that empagliflozin and sitagliptin do not have clinically relevant effects on each other's pharmacokinetics when coadministered.

What precautions should be taken while using SITAGLO E 25/100MG TAB?

• Inform your doctor if you have severe kidney or liver disease, heart problems, or a history of pancreatitis.
• Empagliflozin can cause dehydration and potentially lead to acute kidney injury, especially in patients taking diuretics or those with existing kidney issues. Ensure adequate fluid intake.
• There's a rare risk of diabetic ketoacidosis (DKA) with empagliflozin, even with normal blood sugar levels. Your doctor might advise temporarily stopping the medication during acute illness or before surgery.
• This medication is not suitable for Type 1 diabetes or for treating diabetic ketoacidosis.
• Do not stop taking SITAGLO E 25/100MG TAB suddenly without consulting your doctor, as this can lead to increased blood sugar levels and complications.

What happens if a dose of SITAGLO E 25/100MG TAB is missed?

If you miss a dose, take it as soon as you remember, provided it's not close to the time for your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should SITAGLO E 25/100MG TAB be stored?

Store the medicine in a closed container at room temperature, typically between 68°F to 77°F (20°C to 25°C), away from heat, moisture, and direct light. Keep it in its original blister pack until it's time to take it.