Normet Tablet

NORMET TABLET by ZUVENTUS HEALTHCARE LTD.

NORMET TABLET is a combination antibiotic medication manufactured by Zuventus Healthcare Ltd., used to treat a variety of bacterial and parasitic infections.

Composition

Each film-coated tablet contains:

• Ofloxacin IP 200 mg
• Ornidazole 500 mg

Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA synthesis, preventing bacterial reproduction and repair. Ornidazole is a nitroimidazole derivative that targets and eliminates parasites and anaerobic bacteria by damaging their DNA. This combination provides a broad spectrum of activity.

Uses

NORMET TABLET is prescribed for the treatment of various bacterial and parasitic infections, including:

• Bacterial and parasitic infections causing diarrhea and dysentery
• Urinary tract infections (UTIs)
• Respiratory tract infections (e.g., pneumonia, bronchitis)
• Skin and soft tissue infections
• Eye and ear infections
• Sexually transmitted infections
• Gastrointestinal, lung, and genital tract infections
• Protozoan infections
• As a preventive measure during certain surgical procedures, especially involving the colon and gynecological operations.

Dosage and Administration

For adults, the typical dosage is one tablet twice daily. It is generally recommended to take NORMET TABLET with food at a fixed time for better effectiveness and to reduce stomach discomfort. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. It is crucial to complete the full prescribed course of treatment, even if symptoms improve, to ensure complete eradication of the infection and prevent resistance.

Side Effects

Common side effects may include:

• Nausea, vomiting, stomach pain, or discomfort
• Diarrhea
• Headache, dizziness, or insomnia
• Loss of appetite, dry mouth, changes in taste sensation
• Itching, skin rash, or vaginal inflammation

Serious side effects, though rare, can include tendonitis or tendon rupture, QT interval prolongation, and worsening of myasthenia gravis. If any side effects persist or worsen, medical attention should be sought.

Precautions

• Allergies: Do not take if allergic to Ofloxacin, Ornidazole, any other quinolone antibiotics, nitroimidazoles, or any other components of the tablet.
• Medical Conditions: Inform your doctor about existing liver or kidney issues, heart disease, epilepsy, low potassium levels, nervous or muscle disorders (including myasthenia gravis), head injury, diabetes, rheumatoid arthritis, multiple sclerosis, or psychiatric disorders.
• Pregnancy and Breastfeeding: NORMET TABLET is generally not recommended for use in pregnant or breastfeeding women.
• Alcohol: Avoid alcohol consumption during treatment as it can increase dizziness and other side effects.
• Driving: May cause dizziness and drowsiness; avoid driving or operating machinery if affected.
• Interactions: Inform your doctor about all other medications, supplements, and herbal products being taken.

Storage

Store NORMET TABLET at room temperature, ideally not exceeding 30°C. Protect it from light and moisture, and keep it out of reach of children. Ensure to use before the expiry date.

Here are frequently asked questions about NORMET TABLET by ZUVENTUS HEALTHCARE LTD.:

What is Normet Tablet used for?

Normet Tablet is an antibiotic combination medication primarily used to treat various bacterial and parasitic infections in adults. It is effective for conditions such as diarrhea caused by mixed infections, urinary tract infections (UTIs), respiratory tract infections (like bronchitis and pneumonia), skin and soft tissue infections, eye and ear infections, sexually transmitted infections, and intra-abdominal infections. It can also be used as a preventive measure during certain surgical procedures.

How does Normet Tablet work?

Normet Tablet contains two active ingredients: Ofloxacin and Ornidazole. Ofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial enzymes called DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Ornidazole is a nitroimidazole antibiotic and antiprotozoal agent that disrupts the DNA structure and interferes with protein synthesis in susceptible anaerobic bacteria and protozoa, ultimately causing their death.

What is the usual dosage of Normet Tablet?

The usual recommended dosage is one tablet twice daily, but the exact dose and duration of treatment will be determined by your doctor based on your health condition and response to the medicine. It is crucial to stick to the prescribed dosage and complete the full course of treatment, even if symptoms improve, to ensure complete eradication of the infection and prevent antibiotic resistance. Normet Tablet should be swallowed whole with a glass of water, ideally on an empty stomach, either 1 hour before or 2 hours after meals.

What are the possible side effects of Normet Tablet?

Common side effects of Normet Tablet include nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, difficulty falling asleep (insomnia), mild skin rash, dry mouth, and loss of appetite. Some individuals may experience itching or vaginal inflammation. More serious, though less common, side effects can include tendon disorders (like tendinitis or tendon rupture), confusion, aggression, nervousness, altered mental state, and low blood sugar in diabetic patients. If any side effects persist, worsen, or if you experience allergic reactions, seek immediate medical attention.

Is Normet Tablet safe during pregnancy or breastfeeding?

Normet Tablet is generally not advisable during pregnancy or breastfeeding due to potential risks to the fetus or infant. It is contraindicated in the first trimester of pregnancy and should be avoided if you are pregnant, planning a pregnancy, or breastfeeding. Always consult your doctor before taking this medicine if you are pregnant or breastfeeding.

Can Normet Tablet be taken with other medications?

Normet Tablet can interact with certain medications. It is important to inform your doctor about all other medicines you are taking. Significant interactions include:

• Antacids (containing calcium or magnesium) and Sucralfate: Should not be taken within two hours before or after Normet Tablet.
• Blood thinners (e.g., Warfarin): May enhance the anticoagulant effect, increasing the risk of bleeding.
• NSAIDs (Non-Steroidal Anti-inflammatory Drugs): May heighten the risk of seizures or convulsions.
• Theophylline: May increase levels of theophylline, risking side effects like rapid heart rate and seizures.
• Cyclosporine: May raise cyclosporine levels, potentially leading to kidney problems.
• Alpha-2 adrenergic receptor agonists (e.g., Tizanidine): Could lead to increased levels, causing low blood pressure or sedation.
• Tricyclic antidepressants: May increase side effects like dizziness and confusion.
• Alcohol: Strictly avoid alcohol during treatment and for 48 hours after the last dose due to a potential disulfiram-like reaction, which can cause severe nausea, vomiting, sweating, headache, palpitations, and chest pain.

What precautions should be taken?

Several precautions should be taken:

• Allergies: Do not take if you are allergic to Ofloxacin, Ornidazole, or any other fluoroquinolone antibiotics.
• Alcohol: Avoid alcohol during treatment and for at least 48 hours after the last dose due to possible severe reactions.
• Driving/Operating Machinery: This medicine may cause dizziness or sleepiness; avoid driving or operating machinery until you know how it affects you.
• Kidney/Liver Disease: Use with caution in patients with kidney or liver impairment. Dose adjustment may be required in severe cases.
• Tendon Problems: Inform your doctor if you experience pain or swelling in tendons, as this medicine is associated with an increased risk of tendonitis and tendon rupture. Stop the medicine immediately and do not move the affected joint if this occurs.
• Epilepsy/CNS Disorders: Use with caution in patients with a history of epilepsy, seizures, or other central nervous system abnormalities, as it can lower the seizure threshold.
• Myasthenia Gravis: This medicine can worsen Myasthenia Gravis due to its neuromuscular blocking activity.
• G6PD Deficiency: Patients with Glucose-6-Phosphate Dehydrogenase deficiency may be prone to hemolytic reactions.
• Sun Sensitivity: Normet Tablet may increase sensitivity to sunlight.
• Children: Not recommended for use in individuals under 18 years of age.

What happens if a dose is missed?

If you miss a dose of Normet Tablet, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should it be stored?

Store Normet Tablet at room temperature, typically between 15-30°C (59-86°F), or below 30°C. Keep it protected from light and moisture to maintain its effectiveness. Always keep this medicine out of the reach of children and pets, and use it before the expiry date mentioned on the packaging.