Vogli-m O.2 Tablet

VOGLI-M 0.2 Tablet by MEDLEY PHARMACEUTICALS LTD.

Name

• Brand Name: VOGLI-M 0.2 TABLET
• Common Name: Metformin and Voglibose tablets

Composition

VOGLI-M 0.2 Tablet contains two active ingredients:

• Metformin (500 mg): A biguanide antidiabetic medicine that reduces glucose production by the liver, decreases glucose absorption from the intestines, and enhances the body's sensitivity to insulin.
• Voglibose (0.2 mg): An alpha-glucosidase enzyme inhibitor that delays the breakdown and absorption of carbohydrates in the small intestines, preventing a sudden rise in blood sugar levels after meals.

Uses

VOGLI-M 0.2 Tablet is prescribed for the management of type 2 diabetes mellitus in adults. It is used to:

• Help control high blood sugar levels, especially when diet, exercise, and single-agent therapy are insufficient.
• Reduce the risk of cardiovascular complications in diabetic patients who already have heart disease.
• Assist in maintaining a healthy lifestyle when complemented with regular exercise and a balanced diet.
• Control post-meal high blood sugar levels.

Dosage and Administration

• Take VOGLI-M 0.2 Tablet as instructed by your doctor.
• It is generally recommended to take this medicine with or after meals to reduce gastrointestinal discomfort.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Take the medicine regularly at the same time each day for maximum benefit.
• The dosage may vary based on your health condition and response to the medicine. Never exceed the prescribed dosage without consulting your doctor.

Side Effects

Common Side Effects:

• Diarrhea
• Abdominal pain/Stomach pain
• Nausea
• Vomiting
• Decreased appetite
• Metallic taste in mouth
• Skin rash
• Headache
• Dizziness
• Flatulence/Bloating
• Heartburn

Serious Side Effects (Rare):

• Lactic Acidosis: Symptoms include vomiting, severe stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature.
• Hypoglycemia (low blood sugar levels): Especially when combined with other antidiabetic medicines, alcohol intake, increased exercise, or delayed/missed meals. Symptoms include excessive hunger, headache, shaking, sweating, confusion, anxiety, and fast heartbeat.
• Hepatitis: Inflammation of the liver with symptoms like tiredness, loss of appetite, weight loss, with or without yellowing of the skin or eyes.

Precautions

• Allergy: Do not take if allergic to Metformin, Voglibose, or any of its components.
• Pregnancy and Breastfeeding: Generally not recommended. Consult your doctor if you are pregnant or breastfeeding.
• Alcohol: Avoid excessive alcohol intake as it may increase the risk of lactic acidosis and hypoglycemia.
• Kidney Disease: Use with caution; not recommended for severe kidney disease. Regular monitoring of kidney function is advisable.
• Liver Disease: Use with caution as it could worsen the condition. Regular monitoring of liver function may be necessary.
• Heart Conditions: Caution is advised for patients with heart conditions, as it can increase the risk of heart failure.
• Metabolic Acidosis: Avoid if you have acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Other Conditions: Inform your doctor if you have severe infections, trauma, gastrointestinal obstruction, inflammatory bowel disease, hernia, diabetic pre-coma, or are due to undergo surgery.
• Vitamin B12 Deficiency: Long-term use may reduce Vitamin B12 absorption; annual screening of serum Vitamin B12 levels is recommended.
• Driving and Machinery: VOGLI-M 0.2 Tablet may cause hypoglycemia, which can affect your ability to drive or use machines. Be aware of hypoglycemia symptoms before driving.
• Children and Elderly: Not recommended for children under 18. Use with caution in elderly patients (65 years or above) with frequent kidney function assessment.

Storage

• Store in a cool and dry place, protected from direct sunlight, moisture, and heat.
• Keep out of sight and reach of children.
• Typically stored at room temperature (10ºC to 25ºC or below 30ºC).

What is VOGLI-M O.2 TABLET used for?

VOGLI-M O.2 TABLET is primarily used to manage type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet, exercise, and a single diabetes medicine are not sufficient. It also helps reduce the risk of cardiovascular complications in diabetic patients who already have heart disease.

How does VOGLI-M O.2 TABLET work?

VOGLI-M O.2 TABLET contains two active ingredients: Metformin (500 mg) and Voglibose (0.2 mg). Metformin, a biguanide, reduces glucose production by the liver and decreases glucose absorption from the intestines. It also enhances the body's sensitivity to insulin, aiding in increased glucose uptake and utilization. Voglibose, an alpha-glucosidase inhibitor, works by competitively inhibiting enzymes in the small intestines that break down complex carbohydrates. This slows down the digestion and absorption of glucose into the bloodstream, thereby reducing post-meal blood sugar spikes.

What is the usual dosage for VOGLI-M O.2 TABLET?

The daily dose of VOGLI-M O.2 TABLET should be taken as instructed by your doctor. The dosage can vary based on your health condition and how you respond to the medicine. It is typically taken with meals, often starting with the first meal of the day, to help reduce gastrointestinal discomfort. Always follow the prescribed dosage and do not exceed it without consulting your doctor.

What are the possible side effects of VOGLI-M O.2 TABLET?

Common side effects of VOGLI-M O.2 TABLET include diarrhea, abdominal pain, nausea, vomiting, decreased appetite, and a metallic taste in the mouth. Other possible side effects can include skin rash, headache, and dizziness. Though rare, a serious side effect called lactic acidosis can occur, with symptoms like muscle pain, difficulty breathing, and weakness. If side effects persist or worsen, consult your doctor.

Is VOGLI-M O.2 TABLET safe during pregnancy or breastfeeding?

Caution is advised when taking VOGLI-M O.2 TABLET during pregnancy. It is generally not recommended for use in pregnant or breastfeeding women unless considered necessary by a physician, due to potential severe side effects and the possibility of metformin/voglibose passing into breast milk. It is crucial to discuss the risks and benefits with your doctor before using this medicine if you are pregnant or breastfeeding.

Can VOGLI-M O.2 TABLET be taken with other medications?

VOGLI-M O.2 TABLET can interact with various medications. Medicines like topiramate and acetazolamide (carbonic anhydrase inhibitors) can increase the risk of lactic acidosis. Cationic medicines such as amiloride and digoxin can reduce metformin elimination. Additionally, certain medications like phenothiazines, thyroid products, estrogens, and some blood pressure medications (e.g., propranolol) can affect blood sugar levels, potentially reducing the effectiveness of VOGLI-M O.2 TABLET. Always inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken with VOGLI-M O.2 TABLET?

Avoid excessive alcohol intake while using VOGLI-M O.2 TABLET as it may increase the risk of lactic acidosis, a serious side effect. Patients with severe kidney disease, metabolic acidosis (including diabetic ketoacidosis), or severe liver disease should avoid this medication. Regular monitoring of blood sugar levels is recommended, and if you experience symptoms of low blood sugar (hypoglycemia) such as sweating or dizziness, carry a fast-acting sugar source. It is also important to follow a strict diet regimen and exercise program as advised by your doctor.

What happens if a dose of VOGLI-M O.2 TABLET is missed?

If you forget to take VOGLI-M O.2 TABLET at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for a missed one.

How should VOGLI-M O.2 TABLET be stored?

Store VOGLI-M O.2 TABLET in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of reach of children and pets.